Article Per Year (5 Year)
p-Index From 2019 - 2024
1.288
P-Index
This Author published in this journals
All Journal Althea Medical Journal JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Indian Journal of Forensic Medicine & Toxicology AKSONA
Mohammad Saiful Ardhi
Department Of Neurology, Faculty Of Medicine, Universitas Airlangga; Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Published : 7 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 7 Documents
Search

 1 
Relationship Between High Sensitivity TNF-? WITH clinical outcome During Admission In Acute Ischemic Stroke Mohammad Saiful Ardhi1 , Mohammad Saiful Islam1
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13595

Abstract

Background : Tumor necrosis factor alpha (TNF-?), together with other pro-inflammatory cytokines suchas Interleukin-1b (IL-1b), IL- 6 and IL-8, play a role in the ischemic injury of the central nervous system.TNF-? has adverse effects on ischemic brain tissue. The mechanism generated is a multicomplex process. Inother studies, an increase in TNF-? can actually have neuroprotective effects. This study aims to determinethe relation between the levels of the High Sensitivity TNF-? with clinical outcome in acute ischemic stroke.Method : Thirty patients with acute ischemic stroke patients who admitted in Dr. Soetomo hospital Surabayaduring the period December 2011 to February 2012. 2 cc of vein blood for examination High sensitivityTNF-? was drawn during admission from acute ischemic stroke. Clinical outcome in acute stroke wasmeasured by NIHSS score.Results: From 30 research samples, the mean age of patients was 59.53 ± 11.51 years. The mean HighSensitivity TNF-? level in the study subjects was 2 ± 0.99 pg / ml. NIHSS examination showed the medianvalue of the NIHSS was 5 with a range of 2-19. There is a correlation but not statistically significant withthe strength is very weak between High Sensitivity TNF-? with the NIHSS in patients with acute thromboticstroke (r = 0.100 and p = 0.600).Conclusion: There is relationship between serum levels of High sensitivity TNF-? with clinical outcome inacute ischemic stroke patients.
The Impact Factors of Peripheral Diabetic Neuropathy Which is Along with Hyperglycemia, Hypercholesterolemia, and Hyperaggregation Citra Amaniah Anhar; Yetti Hernaningsih; Puspa Wardhani, Soebagijo Adi; Mohammad Saiful Ardhi
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14696

Abstract

Objective: The prevalence of T2DM case in 2018 has increased by 10.9%. The majority of T2DMpatients often ignore some of the most important conditions to experience complications, which iscomplications of PDN. This study aims to analyze the dominant factors in PDF patients with hyperglycemia,hypercholesterolemia, and hyperaggregation. Material and methods: This research is a case control studyconducted from April to October 2020. The sample is 85 patients who have been confirmed to have PDNby neurologists aged 40 - 65. Sampling was conducted at several hospitals in Surabaya with a purposivesampling method. Data analysis was conducted in three stages, namely univariate analysis, bivariateanalysis and multivariate analysis. Results: 85 PDN patients who experienced hyperglycemia amountedto 81%, hypercholesterolemia 81%, and hyperaggregation 67%. The dominant factor affecting the threeconditions (hyperglycemia, hypercholeterol, and hyperagregation) in this PDN patient was a history ofhypertension with a value of p = {(0.012); (0.007); (0.001)} and also a long period of suffering from T2DMwith p value = {(0.019); (0.025); (0.041)). Meanwhile, age, gender and regularity for treatment control werenot the dominant influencing factors. Conclusion: Suffered for a long time from T2DM and a history ofhypertension are the main determinants of peripheral diabetic neuropathy which is along by hyperglycemia,hypercholesterolemia, and hyperaggregation.
Bleeding Volume, Blood Pressure, and Consciousness Level in Association with the Mortality Rate among Patients with Intracerebral Hemorrhage at Dr. Soetomo General Hospital, Surabaya Mohammad Pratama Jauhar Putra; Achmad Firdaus Sani; Puji Lestari; Mohammad Saiful Ardhi
Althea Medical Journal Vol 7, No 2 (2020)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v7n2.1751

Abstract

Background: Intracerebral hemorrhage is one of the deadliest acute conditions. The volume of bleeding and its location are factors that alter consciousness level, leading to death. This study aimed to explore the association between bleeding volume, blood pressure, and consciousness level with the mortality rate among patients with intracerebral hemorrhage, so proper treatment and diagnosis can be conducted efficiently.Methods: This was an observational retrospective study conducted from October 2018–July 2019. Bleeding volume, blood pressure, consciousness level, and mortality as the outcomes of the patients with intracerebral hemorrhage were evaluated. Consciousness level was determined by using the Glasgow Coma Scale score. Data were collected from the medical record of intracerebral hemorrhage patients of the Neurologic Department in Dr. Soetomo General Academic Hospital Surabaya in the period of 2016. The Chi-square analysis method was used to determine the correlation between variables.Results: In total, 51 medical records were retrieved, and the majority of the patients were in the 45–60 years old group (54.9%). The mortality during hospitalization was 17.6% with most of them (82.4%) had bleeding volume less than 30 cc. Interestingly, the bleeding volume correlated with the consciousness level (p=0.001) and the outcome of the patients (p=0.02). The blood pressure shows a correlation with the volume of bleeding (p=0.009).Conclusions: Bleeding volume and consciousness level as determined by the Glasgow Coma Scale score show significant correlations with the mortality rate in patients with intracerebral hemorrhage. 
Comparison of Clinical Severity Improvement Degree between Acute Thrombotic Stroke Patients with Low and High Matrix Metalloproteinase-9 Levels Muhamad Hamdan1, Hendro Susilo, Paulus Sugianto1, A. Firdaus Sami1, Mohammad Saiful Ardhi1, Sita Set
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3387

Abstract

Background: Stroke is a cause of disability and dependency in both humanity and economic. Studies on the association of Matrix metallopeptidase 9 (MMP-9) levels with improved clinical severity are currently limited. Objectives: To determine the improvement of clinical severity in acute thrombotic stroke patients with high and low MMP-9 levels. Methods: Patients acute thrombotic stroke were grouped into low and high MMP-9 levels. MMP-9 levels were considered low when <840 ng/mL and high when ?840 ng/mL. Clinical severity improvement was assessed using the ?NIHSS scale. Results: Eighty subjects were enrolled that consists of clinical severity improved patients with lower MMP9 (37.9%) that higher than high MMP-9 (21.6%). This difference was not statistically significant (p = 0.115). Conclusion: There was no difference in clinical severity improvement in patients with acute thrombotic stroke with low MMP-9 levels in blood serum compared to high MMP-9 levels.
Profil Pasien Penderita Stroke Perdarahan Serebelum di RSUD Dr. Soetomo Tahun 2013 - 2016 Triagung Arif Pratama; Asra Al Fauzi; Muhammad Saiful Ardhi
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 6 No 2 (2018): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 6.2 Edisi Oktober - D
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pendahuluan: Intracerebellar hemorrhagic (ICH) stroke yang terletak di serebelum adalah salah satu kasus paling sedikit yang ditemukan di antara perdarahan Intraserebral lainnya. Tujuan: untuk meningkatkan pengetahuan, mengidentifikasi profil penderita stroke perdarahan serebelum. Metode: desain penelitian ini bersifat deskriptif observasional. Sampel penelitian adalah pasien dengan stroke ICH serebelum di RSUD Dr. Soetomo pada Januari 2013- Desember 2016. Profil yang diamati meliputi jenis kelamin, umur, status diabetes, dan kebiasaan merokok. Hasil: dari 20 pasien dengan stroke ICH serebelum di RSUD Dr. Soetomo periode 2013 –2016, pasien laki-laki memiliki persentase lebih tinggi yaitu 60% (12 orang) dibandingkan perempuan dengan 40% (8 orang). Sebagian besar pasien memiliki umur rata-rata antara 41 dan 60 dengan persentase 65% (13 orang). 35% (7 orang) pasien memiliki kebiasaan merokok dan pasien dengan latar belakang diabetes terdapat sebanyak 30% (6 orang). Kesimpulan: pasien ICH serebelum sebagian besar adalah pasien laki-laki dan pada umur populasi terbanyak terletak di antara 41-60 tahun. Riwayat diabetes dan kebiasaan merokok juga ditemukan di pasien.
Azathioptrine in Refractory Tolosa-Hunt Syndrome: Two Case Report Devi Ariani Sudibyo; Mohammad Saiful Ardhi
AKSONA Vol. 2 No. 1 (2022): JANUARY 2022
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.809 KB) | DOI: 10.20473/aksona.v2i1.186

Abstract

Introduction: Tolosa-Hunt syndrome (THS) is an inflammatory disease with painful ophthalmoplegia and unilateral periorbital headache as detailed by the International Classification of Headache Disorders, 3rd edition (ICHD-3). Azathioprine has been suggested as a second-line treatment in refractory THS when oral corticosteroid only gives a partial response. Case: Two cases of THS, 45-year-old and 41-year-old women with unilateral headache, drooping of the left upper eyelid, and diplopia. They presented with complete ophthalmoplegia and ophthalmic division of trigeminal nerve disturbance. Magnetic resonance imaging (MRI) showed thickening of the left cavernous sinus, suggesting THS, while the other was normal. Corticosteroid (prednisone 1-1,5 mg/day) was given orally for the first two weeks, and according to the Numeric Pain Rating Scale (NPRS), pain intensity was reduced from severe to moderate. As a second-line treatment, azathioprine (2 mg/kg/day) was given afterward, with a significant reduction in pain intensity and remission of ophthalmoplegia within seven days. Azathioprine was used as an immunosuppressive agent and was continued for another three months without any deterioration in neurological deficits. The levels of complement 3, 4 (C3, C4), and C-reactive protein (CRP) were normal in both patients, with a slight increase in erythrocyte sedimentation rate (ESR) and equivocal values on antinuclear antibody (ANA) results. Other differentials of THS were eliminated from history-taking, physical examination, and proper investigations. Conclusion: Azathioprine as a second-line treatment can be used instead of an oral corticosteroid for refractory cases of THS with fewer side effects. Complete remission of ophthalmoplegia and a significant reduction in pain intensity was obtained.
Partial Transvenous Coil Embolization with Significant Clinical Improvement in Patient with Indirect Carotid Cavernous Fistula Muh. Wildan Yahya; Achmad Firdaus Sani; Dedy Kurniawan; Mohammad Saiful Ardhi
AKSONA Vol. 2 No. 2 (2022): JULY 2022
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (476.891 KB) | DOI: 10.20473/aksona.v2i2.36633

Abstract

Highlight: CCF is a rare vascular malformation with challenging management. Partial transvenous embolization is quite effective as an alternative therapy for indirect CCF type D.   ABSTRACT Introduction: An indirect carotid-cavernous fistula (CCF) is an abnormal connection between the internal or external carotid artery and the cavernous sinus. The optic, trochlear, abducens, and trigeminal nerves are located in the cavernous sinus. Head Computed Tomography (CT) scan, Magnetic Resonance Imaging (MRI), and Cerebral Angiography are some imaging modalities used to establish and diagnose carotid-cavernous fistula. Endovascular intervention can be performed with trans-arterial or trans-venous access. In some cases, complete embolization by endovascular treatment is not possible because of difficult angioarchitecture. Case: A 61-year-old female reported having pain in her left eye (numerical rating scale was 6). The left eye was bulging, reddish, ptosis, and unable to move. The patient felt double vision when opening both eyes, complained of intermittent stabbing headaches on the left side, and heard a bruit from the left side of the head. The cerebral angiography showed bilateral indirect CCF Barrow type D. The procedure involved partial transvenous embolization with coiling. The angiographic evaluation showed partial occlusion, and residual flow from the fistula was still visible on angiography. There was a significant clinical improvement several days after the procedure and a five-month follow-up.  Conclusion: This case report showed that partial targeted transvenous embolization is quite effective in indirect CCF when complete embolization is impossible.
Co-Authors Achmad Firdaus Sani, Achmad Firdaus Asra Al Fauzi Citra Amaniah Anhar Dedy Kurniawan Devi Ariani Sudibyo Mohammad Pratama Jauhar Putra Muh. Wildan Yahya Puji Lestari Puspa Wardhani, Soebagijo Adi Triagung Arif Pratama Yetti Hernaningsih