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Stanza Uga Peryoga
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Health Professions Medicine & Pharmacology

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Antipyretic Effect of Cinnamomum burmannii (Nees & T.Nees) Blume Infusion in Fever-induced Rat Models Qatrunnada Zaino; Eva M. Hidayat; Stanza Uga Peryoga
Althea Medical Journal Vol 1, No 2 (2014)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (307.297 KB)

Abstract

Background: Fever is a frequent clinical sign encountered in human especially in children. Unfortunately, access to health care and medications (antipyretics) are hampered by shortage of services and affordability, which are accentuated by local resources mainly for those living in remote areas. Therefore, using herbal medicineas an alternative in treating fever should be developed as substituent reliance on synthetic antipyretic. This study is conducted to observe antipyretic effect of Cinnamomum burmannii (Nees & T.Nees) Blume infusion using Diphtheria Tetanus Pertussis (DTP) vaccine-induced fever in rats.Methods: Twenty-eight male Wistar rats (150200 g) were randomly allocated into control and treatment groups. Fever was induced with DTP vaccine intramuscularly injected (0.7 mL/200 g body weight) and 4 hours later, distilled water (5 mL) was administered orally to the control group while the treatment group received 5 mL of 3%, 6%, and 12% of cinnamon infusion. Rectal temperature was measured before the pretreatment, 4 hours afterDTP vaccine-induced fever injection and at a 30-minute interval during 180 minutes after the infusion administration. All procedures and protocols were performed in October 2012 at the Pharmacology Laboratory, Faculty of Medicine, Universitas Padjadjaran, Bandung.Results: Data analysis using the one way analysis of variance (ANOVA) showed significant reduction (p<0.001) of rectal temperature after 30 minutes and Duncan Post-Hoc test showed significant effect for  6% and 12% of cinnamon infusion groups.Conclusion The antipyretic effect of 6% and 12% of Cinnamomum burmannii (Nees & T.Nees) Blume infusion in fever-induced rat models is found in the first 30 minutes.Key words: Antipyretic, Cinnamomum burmannii (Nees & T.Nees) Blume, fever, herbal medicine Efek Antipiretik Infusa Cinnamomum burmannii (Nees & T.Nees) Blume pada Tikus yang Diinduksi Demam AbstrakLatar belakang: Demam merupakan suatu gejala yang sering muncul terutama pada anak-anak. Antipiretik merupakan obat yang sering digunakan untuk meringankan demam, namun akses kepada pelayanan kesehatan dan pengobatan masih belum terjangkau bagi penduduk yang tinggal di daerah terpencil. Menggunakan herbal sebagai alternatif pengobatan demam harus dikembangkan sebagai substituen terhadap ketergantungan pada obat sintetik. Penelitian ini dilakukan dengan tujuan untuk mengetahui efek antipiretik infusa Cinnamomum burmannii (Nees & T.Nees) Blume pada tikus yang diinduksi demam menggunakan vaksin Diphtheria Tetanus Pertussis (DTP).Metode: Penelitian yang dilakukan menggunakan 28 ekor tikus putih jantan galur Wistar yang dikelompokkan secara acak dan diinjeksi dengan vaksin DTP (0.7 mL/200 g BB) secara intramuskular untuk menimbulkan demam. Setelah 4 jam, kelompok kontrol diberikan 5mL air suling per oral dan kelompok uji diberikan infusa Cinnamomum burmannii (Nees & T.Nees) Blume per oral dengan dosis masing-masing 3%/5 mL, 6%/5 mL dan 12%/5 mL. Pengukuran suhu tubuh dilakukan melalui rektal sebelum pemberian vaksin DTP, 4 jam setelah pemberian vaksin DTP dan 30 menit interval setelah perlakuan sampai menit 180. Semua prosedur dan protokol dilaksanakan pada Oktober 2012 di Laboratorium Farmakologi, Fakultas Kedokteran, Universitas Padjadjaran, Bandung.Hasil: Hasil analisis data menggunakan uji ANOVA menunjukkan penurunan yang signifikan (p<0.001) dari suhu rektal pada menit 30 dan dengan uji Duncan Post-Hoc menunjukkan efek yang signifikan pada kelompok yang diberikan 6%/5 ml dan 12%/5 mL infusa Cinnamomum burmannii (Nees & T.Nees) Blume. Pada menit 60–180 tidak ada penurunan yang signifikan (p>0.05) dari suhu rektal, dimungkinkan karena durasi kerja yang singkat dari Cinnamomum burmannii (Nees & T.Nees) Blume.Simpulan: Efek antipiretik pada pemberian dosis 6% dan 12% infusa Cinnamomum burmannii (Nees & T.Nees) Blume pada tikus yang diinduksi demam ditemukan pada 30 menit pertama.Kata kunci: Antipiretik, Cinnamomum burmannii (Nees & T.Nees) Blume, demam, pengobatan herbal DOI: 10.15850/amj.v1n2.352
The risk for delayed development in low birth weight, appropriate for gestational age preterm infants Stanza Uga Peryoga; Abdurachman Sukadi; Sambas Wiradisuria
Paediatrica Indonesiana Vol 45 No 4 (2005): July 2005
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi45.4.2005.154-9

Abstract

Background Preterm infants, particularly those who have hadsevere asphyxia, hyperbilirubinemia, and sepsis, tend to be at riskfor neurodevelopmental impairment.Objective The purpose of this study was to assess the risk for de-layed development in low birth weight (LBW), appropriate for gesta-tional age (AGA) preterm infants compared to that in term, non-LBWinfants, and to investigate the roles of severe asphyxia, sepsis, andhyperbilirubinemia as potential risk factors for delayed development.Methods This was a hospital-based retrospective cohort studyinvolving preterm, LBW and term, non-LBW infants conducted inHasan Sadikin Hospital, Bandung. The Bayley InfantNeurodevelopmental Screener (BINS) test was performed to as-sess the risk of delayed development at 3 months of corrected agefor the preterm infants and at 3 months of chronological age for theterm infants. Bivariate analysis using the chi-square test and mul-tivariate analysis using logistic regression were performed.Results One hundred and twelve infants fulfilled eligibility criteria,consisting of 52 preterm, LBW and 60 term, non-LBW infants. Basedon the BINS test, of the preterm, LBW infants, 32 (61%) were atlow risk, 11 (21%) at moderate risk, and 9 (17%) at high risk fordelayed development. Of the control infants, 49 (82%) were at lowrisk, 10 (17%) at moderate risk, and 1 (1.7%) at high risk for de-layed development. Logistic regression analysis showed signifi-cant association between accompanying diseases such as sepsis(OR=25.60; P=0.001) and hyperbilirubinemia (OR=16.07; P=0.001)with delayed development. Despite more than twofold odds fordelayed development in infants with severe asphyxia (OR=2.51)and LBW-prematurity (OR=2.47), the association was statisticallyinsignificant (P=0.20 and P=0.15, respectively).Conclusions In preterm infants appropriate for gestational age,prematurity and low birth weight alone may or may not predisposeto delayed development at 3 months of age. However, the risk fordelayed development in such infants is increased when sepsis orhyperbilirubinemia is present
Co-Authors Abdurachman Sukadi Eva M. Hidayat Qatrunnada Zaino Sambas Wiradisuria