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Khadijah Rizky Sumitro
Department of Child Health, Faculty of Medicine, Universitas Airlangga/ Dr Soetomo Hospital, Surabaya
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Influence of n-3 Fish Oil-Enriched Intravenous Lipid Emulsion on Length of Stay and Mortality in Infants Post Intestinal Surgery Meta Herdiana Hanindita; Khadijah Rizky Sumitro; Nur Aisiyah Widjaja; Roedi Irawan; Boerhan Hidayat
Health Notions Vol 3, No 3 (2019): March
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hn.v3i3.314

Abstract

Background: Parenteral nutrition plays an important role in the infants post intestinal surgery. Currently, n-6 soybean oil-based intravenous lipid emulsion (IVLE) is used as a standard. n-6 have been shown increases biomarkers of inflammation while n-3 have shown positively influence clinical outcomes due to their immunomodulatory action. The aim of this study is to investigate the influence of n-3 fish oil-enriched IVLE on mortality and length of stay in infants post intestinal surgery. Methods: A medical record retrospective study was undertaken in infants post intestinal surgery at Dr. Soetomo Hospital in 2016-2017. Infants with intestinal atresia who had PN for at least three days were included. The n-6 soybean oil-based and n-3 fish oil-enriched IVLE were used. Incomplete data was excluded. Results: There were 19 infants (12/19 boys) included in this study. 10/19 infants received the n-6 soybean oil-based IVLE. The duration and dose of IVLE used were 16.52±11.34 days and 1.80±0.44 g/kg/day. Mortality rate was significantly lower in n-3 fish oil-enriched IVLE group (P=0.02) while there was no difference on length of stay (P=0.484).Conclusion: Infants who received the n-3 fish oil-enriched IVLE have a lower mortality rate but there is no difference on length of stay. Keywords: Infants, Intestinal surgery, Intravenous lipid emulsion, Length of stay, Mortality
Co-Authors Boerhan Hidayat Meta Herdiana Hanindita Nur Aisiyah Widjaja Roedi Irawan