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All Journal KLOROFIL: Jurnal Ilmu Biologi dan Terapan KLOROFIL: Jurnal Ilmu Biologi dan Terapan Jurnal Jeumpa Jurnal Tadris IPA Indonesia Jurnal Sains dan Pendidikan Biologi
Raudhah Hayatillah
UIN Ar-Raniry Banda Aceh
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Immunology & microbiology Physics Social Sciences

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Pengaruh Konsumsi Alkohol terhadap jumlah Eritrosit dan Hemoglobin Mencit (Mus musculus) Raudhah Hayatillah; Widie Kemala Hapsari; Syukriah Syukriah
KLOROFIL: Jurnal Ilmu Biologi dan Terapan Vol 5, No 2 (2021): KLOROFIL: JURNAL ILMU BIOLOGI DAN TERAPAN
Publisher : Program Studi Biologi Fakultas Sains dan Teknologi Universitas Islam Negeri Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30821/kfl:jibt.v5i2.10335

Abstract

Alcohol is an organic compound that is often used in our life. In science research, alcohol is used as a solvent, fuel, and antiseptic. Alcohol if consumed in large quantities has side effects on the body that affect physiologically, one of which is nerve damage, liver and kidney damage, and affects the fetus if consumed by pregnant women. In addition, it is known that alcohol can affect erythrocytes and hemoglobin. In this study, alcohol was given to mice (Mus musculus) to see the effect on the number of erythrocytes and hemoglobin. This study used beer concentrations of 4% and 1% and distilled water as a control. The experimental animals used were 9 mice which would be induced by 1 mL of alcohol for 5 days. The parameters used were the number of erythrocytes and hemoglobin. Data collection was carried out 3 times after 5 days of alcohol induction. The result of this study is that alcohol can reduce the number of erythrocytes and hemoglobin in mice. Decreased erythrocytes and hemoglobin in mice  have an impact on other body organ damage.
Pengaruh Konsumsi Alkohol terhadap jumlah Eritrosit dan Hemoglobin Mencit (Mus musculus) Raudhah Hayatillah; Widie Kemala Hapsari; Syukriah Syukriah
KLOROFIL: Jurnal Ilmu Biologi dan Terapan Vol 5, No 2 (2021): KLOROFIL : JURNAL ILMU BIOLOGI DAN TERAPAN
Publisher : Program Studi Biologi Fakultas Sains dan Teknologi Universitas Islam Negeri Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30821/kfl:jibt.v5i2.10335

Abstract

Alcohol is an organic compound that is often used in our life. In science research, alcohol is used as a solvent, fuel, and antiseptic. Alcohol if consumed in large quantities has side effects on the body that affect physiologically, one of which is nerve damage, liver and kidney damage, and affects the fetus if consumed by pregnant women. In addition, it is known that alcohol can affect erythrocytes and hemoglobin. In this study, alcohol was given to mice (Mus musculus) to see the effect on the number of erythrocytes and hemoglobin. This study used beer concentrations of 4% and 1% and distilled water as a control. The experimental animals used were 9 mice which would be induced by 1 mL of alcohol for 5 days. The parameters used were the number of erythrocytes and hemoglobin. Data collection was carried out 3 times after 5 days of alcohol induction. The result of this study is that alcohol can reduce the number of erythrocytes and hemoglobin in mice. Decreased erythrocytes and hemoglobin in mice  have an impact on other body organ damage.
Pengaruh Konsumsi Alkohol terhadap Subkronik Hepar dan Keseimbangan Tubuh pada Mencit (Mus musculus) Raudhah Hayatillah; Widie Kemala Hapsari
Jurnal Jeumpa Vol 9 No 2 (2022): Jurnal Jeumpa
Publisher : Program Studi Pendidikan Biologi, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Samudra

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Abstract

Alkohol merupakan salah satu senyawa organik yang banyak digunakan dalam kehidupan sehari-hari, seperti dalam bidang penelitian digunakan sebagai bahan sterilisasi, antiseptik, pelarut senyawa, selain itu alkohol juga dapat dikonsumsi dalam jumlah dan kadar tertentu, jika alkohol dikonsumsi dalam jumlah yang berlebihan dan terus menerus, maka dapat merusak organ tubuh yang dapat mempengaruhi homeostasis. Untuk melihat pengaruh alkohol pada tubuh, maka dilakukan penelitian untuk mengamati kerusakan hepar subkronis dan keseimbangan akibat pemberian alkohol pada mencit, metode yang digunakan adalah mengamati morfologi hepar, indeks hepatosomatik, menghitung kadar serum glutamat piruvat transaminase (SGPT) dan uji berenang paksa. Hasil penelitian menunjukkan bahwa alkohol dapat menyebabkan kerusakan subronik pada hepar dan keseimbangan tubuh pada mencit, kerusakan hepar mencit dapat mempengaruhi metabolisme dan fungsi organ tubuh lainnya. Alkohol diketahui dapat mengativasi sel kupffer untuk memproduksi mediator toksik yang dapat menyebabkan kerusakan pada hepar, selain itu alkohol juga menyebabkan penghambatan neurotransmitter berupa sel GABA yang menghalangi penyampaian implus.
Review Artikel: Potensi Tenggek Burung (Melicope ptelefolia) sebagai Kandidat Obat Widie Kemala Hapsari; Raudhah Hayatillah
Jurnal Tadris IPA Indonesia Vol. 3 No. 1 (2023)
Publisher : Tadris IPA IAIN Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21154/jtii.v3i1.1572

Abstract

Tenggek burung (Melicope ptelefolia) merupakan famili Rutaceae, merupakan tanaman herba yang dapat hidup setinggi 1-14 m, banyak ditemukan di daerah Riau, dan juga ditemukan di Malaysia, Vietnam dan China. Tenggek burung biasa dikonsumsi dan dimanfaatkan dalam kehidupan sehari-hari dan diyakini memiliki manfaat secara klinis. Tujuan penulisan artikel ini adalah untuk mengetahui potensi tenggek burung sebagai kandidat tanaman obat. Metode yang digunakan adalah studi literatur, literatur online didapat dari jurnal publikasi lokal maupun internasional yang diperoleh dari penyedia jurnal di internet menggunakan mesin pencari google. Hasil yang didapat menunjukkan bahwa tanaman tenggek burung memiliki kandungan metabolit alam yang dapat berperan sebagai antioksidan, tenggek burung diketahui memiliki senyawa bioaktif seperti fenolik, flavonoid, saponin dan senyawa bioaktif lainnya. Kandungan senyawa bioaktif tersebut dapat berperan sebagai penangkal radikal bebas untuk menggurangi terjadinya stres oksidatif, selain itu adanya kandungan bioaktif yang terkandung pada tanaman tenggek burung membuat tanaman ini memiliki potensi sebagai kandidat obat yang dapat dikembangkan dikemudian hari.
Anti-Inflamasi Tanaman Kedondong (Spondias Dulcis G. Forst.): Review Raudhah Hayatillah; Widie Kemala Hapsari
Jurnal Sains dan Pendidikan Biologi Vol 2 No 1 (2023): Education and Sains
Publisher : Universitas Muslim Buton

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Abstract

Technological developments are currently growing, this can be seen from the increasing lifestyle of people, one of which is the increased consumption of fast food or junk food, it is known that fast food has low nutritional content and high calories, so it can trigger inflammation in the body accompanied by the emergence of disease. which is harmful to the body if consumed for a long time. To minimize the occurrence of disease, in recent years scientists have been intensively conducting research on the discovery of new drugs derived from plants, one of the plants that has the potential as an anti-inflammatory is the kedondong plant. The purpose of writing this article is to find out the potential of the kedondong plant as an antioxidant and anti-inflammatory. Based on testing with several extraction methods and compound test methods, bioactive compounds were found, the compounds contained were phenolics, tannins, saponins and flavonoids which are a group of antioxidant compounds. These compounds were found in leaves, stems, fruits and roots, every part of the kedondong plant has bioactive compounds, through tests carried out. The bioactive compounds in kedondong are known to reduce the expression of iNOS, TLR4, Th1, interleukin (IL) and cytokines genes, these genes are expressed genes in the process of inflammation. So that the antioxidant content in the kedondong plant has the potential as an anti-inflammatory by inhibiting the genes that are expressed in the process of inflammation. The content of bioactive compounds contained is also influenced by the solvent in the extraction process carried out.
Co-Authors Syukriah Syukriah Widie Kemala Hapsari Widie Kemala Hapsari Widie Kemala Hapsari Widie Kemala Hapsari