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All Journal Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) E-Dimas: Jurnal Pengabdian kepada Masyarakat AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal SOLMA SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan JSFK (Jurnal Sains Farmasi & Klinis) JPSCR : Journal of Pharmaceutical Science and Clinical Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JCPS (Journal of Current Pharmaceutical Sciences) JURNAL FARMASIMED (JFM) Majalah Farmasetika Jurnal ABDINUS : Jurnal Pengabdian Nusantara BERNAS: Jurnal Pengabdian Kepada Masyarakat Jurnal PkM (Pengabdian kepada Masyarakat) Journal of Pharmaceutical and Sciences.
Nining Nining
Fakultas Farmasi Dan Sains Universitas Muhammadiyah Prof. DR. HAMKA
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Journal : Journal of Pharmaceutical and Sciences.

 1 
Pengaruh ball milling pada dispersi padat ibuprofen dengan pembawa HPMC terhadap ukuran partikel dan kecepatan disolusi kapsul Nining Nining; Inding Gusmayadi; Febri Romansyah
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 1 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i1.250

Abstract

One factor that greatly influences the active drug solubility is particle size. Ibuprofen is a non-steroidal anti-inflammatory that is poorly water-soluble, potentially slowing its drug dissolution. Milling is one way to reduce particle size and help to enhance drug dissolution. This research aims to study the milling process effect on the particle size of ibuprofen and the capsule dissolution rate. Micrometer-sized ibuprofen (P1) is processed to nanometer size using the wet-milling method for 15 hours (P2) and 20 hours (P3) using HPMC (Hydroxy Propyl Methyl Cellulose) as a stabilising polymer. All particles were evaluated for particle size, and FTIR was tested and formulated into capsules. The powder mass was evaluated for flow properties. Capsule evaluation was also carried out, which included a disintegration time test, weight uniformity test, and dissolution test. The three particles have sizes of 40.6 µm (P1), 438.9 ± 20.9 nm (P2), and 267.1 ± 4.1 nm (P3). FTIR test results show compatibility between ibuprofen and HPMC. The disintegration time test results and capsule weight uniformity met the compendial requirements. Based on the dissolution test, the three formulas showed significant differences (sig p 0.0002 < 0.05) in the per cent dissolution. Obtained Q60 F1-F3 respectively were 99.61 ± 8.75%; 110.03±5.97%; and 115.95 ± 3.34%. The conclusion obtained is that the milling process has a significant effect on the dissolution percentage of ibuprofen.
Co-Authors Abu Rijal Algifari Agustin Yumita anisa amalia Anisa Amalia Ari Widayanti Dania Athaya Putri Devi Puspita Sari Ema Dewanti Febri Romansyah Fith Khaira Nursal Fujianti Fujianti Inding Gusmayadi Kori Yati Naniek Setiadji Radjab Poppy Mutiara Indah Pramulani Mulya Lestari Pramulani Mulya Lestari Putri Nabila Zulvianti Ristianti Azharita Saleh Wikarsa Sundani Nurono Seowandhi Supandi Tahyatul Bariroh Winda Sulistiyaningrum Yeni Yeni Yeni Yeni Yeni Yeni Yeni Yeni