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All Journal Journal of Food and Pharmaceutical Science Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Journal of Pharmaceutical and Medicinal Sciences Journal Syifa Sciences and Clinical Research (JSSCR) Majalah Farmasetika Jurnal farmasi UIN Alauddin Makassar Jurnal Sains dan Kesehatan Jurnal Pengabdian Nusantara (JPN) MOSIRAHA : Jurnal Pengabdian Farmasi Lansau: Jurnal Ilmu Kefarmasian Journal of Food and Pharmaceutical Sciences Borneo Journal of Pharmacy
Wa Ode Sitti Zubaydah
Faculty Of Pharmacy, Universitas Halu Oleo
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Journal : Borneo Journal of Pharmacy

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Anti-inflammatory Activity of Pharmaceutical Gel of Ethanolic Extract from Marine Sponge Xestospongia Sp Wa Ode Sitti Zubaydah; Wahyuni Wahyuni; Sahidin Sahidin; Tian Amalia Halik; Rina Andriani; Astrid Indalifiany; Adryan Fristiohady
Borneo Journal of Pharmacy Vol. 2 No. 1 (2019): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v2i1.694

Abstract

The aim of this study was to determine the characteristics of the gel formula based on it’s organoleptic properties, pH, viscosity, dispersion and homogenity by stability test carried out using the cycling test method and to determine the anti-inflammatory activity of the Xestospongia Sp. in male white mice (Mus musculus) by creating an artificial edema on the mice left foot induced by 1% λ-carrageenan. The gel formula from the ethanol extract of Xestospongia Sp. sponge was physically stable in terms of its organoleptic observation, homogenity, pH and viscosity test. However, the results that were obtained after dispersion test did not fulfill the requirements. In this study, the gel formula of the ethanol extract of Xestospongia Sp. sponge was administered on the mice left foot by using the variations in extract concentration of 0.02%, 0.03%, and 0.04%, and the gel without extract as a negative control and Galtaren®gel (1% Diclofenac Sodium) as a positive control. The evaluated data were in the form of mice leg edema volume measured based on its percent of inflammation and percent of inflammatory inhibition and observed for 360 minutes. The data were analyzed by using the Kruskal-Wallis test followed by the Mann-Whitney test with a confidence level of 95%. The results of this study showed that the gel formula of ethanol extract of Xestospongia Sp. sponge has an anti-inflammatory effect on each concentration and the formula that has a large anti-inflammatory effect was obtained at extract concentration of 0.04%.
Co-Authors Adryan Fristiohady Amilia Primawanty Andryani Ningsih Arfan Arfan Astrid Indalifiani Astrid Indalifiany Devi Hidayati Dian Munasari Elvira Riskiyani Kasim Fadhliyah Malik Fery Indradewi Armadany H Halik Halimahtussaddiyah R Ines Septiani Irvan Anwar Muhammad Handoyo Sahumena Muhammad Handoyo Sahumena Nur Illiyyin Akib Nur illiyyin Akib Nur Illiyyin Akib Nur Illiyyin Akib Nur Janna Kurniawati Nurramadhani A. Sida Nurull Hikmah R Ramlah Restu Nur Hasanah Rifa'atul Mahmudah Rifa'atul Mahmudah Rifa’atul Mahmudah Rifa’atul Mahmudah Rina Andriani Rina Andriani Sahidin Sahidin Sahidin Sahidin Selly Septi Fandinata Sitti Raodah Nurul Jannah Sitti Raodah Nurul Jannah Sunandar Ihsan Suryani Suryani Tian Amalia Halik Vica Aspadiah Wahyuni Wahyuni Yamin Yamin Yamin