Article Per Year (5 Year)
p-Index From 2019 - 2024
0.23
P-Index
This Author published in this journals
All Journal Jurnal Matematika & Sains
Endang Kumolosasi
UBI Farmasi Rumah Sakit/Farmakologi-Toksikologi ITB
Mathematics

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Toksisitas Akut dan Penentuan DL50 Oral Ekstrak Air Daun Gandarusa (Justicia gendarussa Burm. F.) pada Mencit Swiss Webster Andreanus A. Soemardji; Endang Kumolosasi; Cucu Aisyah
Jurnal Matematika & Sains Vol 7, No 2 (2002)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Acute toxicity test of water extract of “gandarusa” (Justicia gendarussa Burm F.) leaves in Swiss Webster mice and oral median lethal dose (LD50) determination by four methods had been performed. Results showed that “gandarusa” leaves have toxic effect on central nerveus system. Oral LD50 by Miller-Tainter method, Reed-Muench method, Kärber method, and calculation method of Farmakope Indonesia 3rd edition in male mice had the same value as that in female mice i.e. 21.00, 21.03, 22.50, and 21.60 g/kg body weight respectively. Miller-Tainter method produced the lowest LD50 value.
Efek Teratogenik Ekstrak Etanol Kulit Batang Pule (Alstonia scholaris R.Br) pada Tikus Wistar Endang Kumolosasi; Andreanus A. Soemardji; Komar Ruslan W.; Hasti Yuliani
Jurnal Matematika & Sains Vol 9, No 2 (2004)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The teratogenic effect of ethanolic extract of “pule” (Alstonia scholaris R.Br., Apocynaceae) bark at repeated doses of 490 and 980 mg/kg body weight administered orally to pregnant Wistar rats for 19 days had been studied. Each dose caused miscarriage in 9.1% of the rats and mild hydrocephalus in 23.1% of the fetuses (dose 490 mg/kg body weight) and in 12.0% of the fetuses (dose 980 mg/kg body weight).
Co-Authors Andreanus A. Soemardji Arief, Ilham Cucu Aisyah Hasti Yuliani Komar Ruslan W. Tomi Hendrayana