Article Per Year (5 Year)
p-Index From 2019 - 2024
0.444
P-Index
This Author published in this journals
All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Surya Medika
Adam Ferdian Sigit Pratama
Universitas Sari Mulia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Formulasi Sediaan Tablet Effervescent dari Ekstrak Etanol Tanaman Bundung (Actionoscirpus grossus) sebagai Antioksidan Noval Noval; Ilham Kuncahyo; Adam Ferdian Sigit Pratama; Syafira Nabillah; Roosma Hatmayana
Jurnal Surya Medika (JSM) Vol 7 No 1 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i1.2649

Abstract

Bundung (Actinoscirpus grossus) is a plant that contains an antioxidant compound proven in previous studies, which has a moderate antioxidant or IC50 by 128 ppm. Antioxidant compounds can reduce the negative impact of oxidants, including metal binding enzymes and proteins. Antioxidant compounds act by donating one electron to the oxidant compound to inhibit oxidants activity. The purpose of this study was to formulate the Bundung plant extract into effervescent tablets, obtain effervescent samples that are physically stable, and can be used as antioxidants to inhibit free radicals in the body. The research method was experimental by using scoring parameters to determine the most optimal formulation. Physical evaluation includes organoleptic, weight uniformity, friability, hardness, and dissolving time. The results showed that the optimum formula was the formula I with a concentration of 68 mg of citric acid and sodium bicarbonate. Tablet effervescent is a brown color and characteristic odor of Bundung plant extract. Effervescent tablets have an weight uniformity (0.314 grams), friability (0.05%), hardness (7.75 ± 0.43 kg). Variations in citric acid and sodium bicarbonate concentration can affect uniformity, friability, hardness, and dissolving time. Room conditions cause this during the production process of effervescent tablets.
Formulation and Evaluation of Chitosan as Disintegrant for Fast Disintegrating Tablet with Fennel Seed Extract (Foeniculum vulgare) Adam Ferdian Sigit Pratama; Setia Budi; Melviani Melviani
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 20, No 1 (2023): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v20i1.7272

Abstract

Kitosan merupakan polimer yang berasal dari cangkang hewan laut yang berpotensi digunakan sebagai disintegran. Kitosan diformulasikan dengan ekstrak biji adas menjadi sediaan Fast Disintegrating Tablet (FDT) ini untuk meningkatkan efektifitas terapi pada pasien. Penelitian ini bertujuan untuk mengetahui pengaruh kitosan sebagai disintegran pada sifat fisik FDT Ekstrak Biji Adas. Metode penelitian menggunakan metode quasi experimental dengan rancangan one-group post-test only. Dibuat 4 formula FDT dengan variasi jumlah kitosan yaitu 6 (F1), 12 (F2), 18 (F3) dan 24 (F4). Tablet dievaluasi secara organoleptis, keseragaman bobot, keseragaman ukuran, kekerasan, kerapuhan, waktu hancur, waktu pembasahan, dan waktu disintegrasi. Hasil penelitian dianalisis secara deskriptif dan statistik menggunakan one-way ANOVA dilanjutkan post-hoc tukey. Hasil evaluasi fisik dihasilkan tablet berwarna coklat tua, berbau aromatik adas, rasa pahit pedas, dan bentuk bulat. F2 memiliki kekerasan 3,3 kg kerapuhan 0,56% waktu hancur 162 detik pembasahan 10,08 menit dan disintegrasi 54 detik memenuhi semua ketentuan tablet FDT. F1, 3, dan 4 tidak sesuai dengan persyaratan tablet FDT. Kitosan 4% dapat digunakan sebagai disintegran dan memberikan pengaruh aspek kekerasan, kerapuhan, waktu hancur dan waktu pembasahan.
Co-Authors Ilham Kuncahyo, Ilham Melviani Melviani Noval Noval Roosma Hatmayana Setia Budi Syafira Nabillah