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All Journal As-syifaa Jurnal Farmasi
Safriani Rahman
Fakultas Farmasi, Universitas Muslim Indonesia, Makassar
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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UJI EFEK ANTIRHEUMATOID ARTRITIS EKSTRAK n-BUTANOL DAUN PETAI CINA (Leucaena leucocephala (Lam.) de Wit) PADA TIKUS JANTAN YANG DIINDUKSI COMPLETE FREUND`S ADJUVANT Sitti Amirah; Safriani Rahman; Rahmatia S Hi Amin
As-Syifaa Jurnal Farmasi Vol 13, No 1 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i1.763

Abstract

Rheumatoid arthritis is an autoimmune disease characterized by chronic inflammation. The research animed to determine the effect of n-butanol extract of Leucaena leucocephala leaves and the effective dose as antirheumatoid arthritis. It used 15 male rats divided into 5 groups: group I (negative control) was given Na-CMC; group II (positive control) was given a suspension of Methylprednisolone; group III, IV dan V were give the extraxt with doses of 83,3 mg/kgBW, 166,6 mg/kgBW and 333,2 mg/kgBW. The treatment was started by inducing Complete Freund`s Adjuvant intraplantary of 0,1 mL and let it remain until day 16. The therapy was conduction for 14 days orally and the foot volume measurements and observation of the arthritis index were performed on day 17 and 31st. In conclusion, the n-butanol extract of Leucaena leucocephala  leaves had the effect as antirheumatoid
UJI EFEK EPITELISASI EKSTRAK DAUN EKOR NAGA (Rhaphidophora pinnata (L.f) Schott.) PADA TIKUS Safriani Rahman; Andi Maulana Kamri
As-Syifaa Jurnal Farmasi Vol 11, No 1 (2019): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (160.498 KB) | DOI: 10.33096/jifa.v11i1.516

Abstract

Burns are damage to the skin due to contact with sources of heat and radiation. The stage of handling burns involves several phases, namely the inflammatory phase, proliferation and maturation.  This study aims to determine the effect of epithelialization of ethanol extract of dragon tail leaves (Rhaphidophora pinnata (L.f) Schott.) In the process of wound healing. This research was conducted in an experimental laboratory and used rat test animals. 15 animals were divided into 5 groups consisting of group I (control) given Na.CMC, group II were given bioplacenton ointment, group III, IV and V (group given) giving ethanol leaves Rhaphidophora pinnata extract. Giving is done twice a day for 14 days. The wound is made by inducing the back of a mouse with a hot plate of 100o C for 2 seconds.. The results of the study data are the average wound diameter and percent of wound reduction in statistics using oneway ANOVA and LSD follow-up test. Based on the results of the research that has been done, it can be concluded that the ethanol extract of dragon tail leaves  has the effect of epithelialization in rats.
AKTIVITAS ANTIMIKROBA EKSTRAK ETANOL BATANG WOLE WOE ASAL HALMAHERA TENGAH TERHADAP BAKTERI GRAM POSITIF Staphylococcus epidermidis DAN Staphylococcus aureus Fitriana Fitriana; Sitti Amirah; Safriani Rahman
As-Syifaa Jurnal Farmasi Vol 14, No 1 (2022): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v14i1.793

Abstract

The wole woe plant is one of the plants empirically used by the Weda community in Central Halmahera district as a traditional medicine to treat various diseases such as breast cancer, cysts, vaginal discharge, diabetes mellitus, wounds, dysentery, cholesterol, and gout. Therefore, a study was conducted on the antimicrobial activity of the ethanolic extract of wole woe stems against gram-positive bacteria S. epidermidis and S. aureus with the aim of determining the concentration that provides antimicrobial activity of the ethanolic extract of wole woe stems by using the agar diffusion method. The results obtained in the screening test gave activity at a concentration of 0.1% and the results of the minimum inhibitory concentration test (MIC) and the minimum killing concentration test (MBC) obtained a MIC value of 1.6% for S. epidermidis bacteria and 0.8% for S. aureus bacteria, while the MBC value is 1.6% for both bacteria. The results of statistical tests on the diameter of the inhibition zone from the antimicrobial activity test against S. epidermidis and S. aureus, showed that there was a difference in the ability to inhibit bacterial growth between the positive control and the test concentration group of 2.5%, 5% and 10%. In the ratio of the inhibitory ability of bacteria at a spesific concentration, the test results showed that S. epidermidis bacteria had different bacterial growth inhibition abilities with S. aureus bacteria. Based on the results obtained, the ethanol extract of wole woe stems has potential as an antimicrobial.
UJI TOKSISITAS EKSTRAK ETANOL BATANG KAYU WOLE WOE TERHADAP LARVA Artemia salina Leach MENGGUNAKAN METODE Brine Shrimp Lethality Test (BSLT) Virsa Handayani; Safriani Rahman; Andi Nur Alam Amaliah
As-Syifaa Jurnal Farmasi Vol 14, No 2 (2022): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v14i2.901

Abstract

The Wole Woe plant is one of the plants that is empirically used as traditional medicine by the Weda community in Central Halmahera Regency. The stem part of the Wole Woe plant is used to treat various diseases. This study aims to determine the toxicity of Wole Woe logs using the Brine Shrimp Lethality Test (BSLT) method. This research was started by extracting Wole Woe logs using ethanol 70% solvent with the reflux method and then carried out phytochemical screening which showed that Wole Woe logs contained alkaloids, flavonoids, saponins, triterpenoids, and tannins compounds. Toxicity testing of Wole Woe wood stem ethanol extract against Artemia salina Leach larvae was divided into 5 test groups, namely 4 treatment groups (concentrations of 250 ppm, 500 ppm, 750 ppm, and 1000 ppm) and 1 control or comparison group (sea water). Each concentration was made in 3 vials containing 10 larvae of Artemia salina Leach. Observations were made by looking at the mortality of Artemia salina Leach larvae after 24 hours of treatment. The results of the study can be seen through probit analysis by calculating the LC50 value. The LC50 of the ethanol extract of Wole Woe logs is 453.942 ± 59.564 g/mL. This indicated that the ethanolic extract of Wole Woe logs had a toxic effect on Artemia salina Leach larvae because the LC50 value was< 1000 ppm
POTENSI ANTIBAKTERI EKSTRAK ETANOL BATANG WOLE WOE ASAL HALMAHERAH TENGAH TERHADAP BAKTERI Pseudomonas aeruginosa dan Bacillus subtilis MENGGUNAKAN METODE DIFUSI AGAR Fitriana Fitriana; Sitti Amirah; Safriani Rahman; Bayu Putra
As-Syifaa Jurnal Farmasi Vol 14, No 2 (2022): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v14i2.904

Abstract

The wole woe plant empirically in the community in Central Halmaherah district is used to treat various diseases, such as breast anticancer, cysts, vaginal discharge, diabetes mellitus, wounds, dysentery, cholesterol, and uric acid, which is thought to have bioactive compounds, that is antibacterial compounds. Therefore, a study was conducted to determine the antibacterial potential of the ethanol extract of wole woe stems against Pseudomonas aeruginosa and Bacillus subtilis bacteria using the agar diffusion method. The results of the screening test showed activity at a concentration of 0.1% and the results of the minimum inhibitory concentration test (MIC) and the minimum killing concentration test (MBC) obtained 1.6% for Pseudomonas aeruginosa bacteria. For Bacillus subtilis bacteria, the MIC value is 0.2% and the MBC value is 3.2%. The statistical test results of the inhibition zone diameter data from the antibacterial activity test against Pseudomonas aeruginosa and Bacillus subtilis bacteria showed that there was a difference in the ability to inhibit bacterial growth between the positive control and the test concentration group of 2.5%, 5% and 10%. The results obtained from the ethanol extract of wole woe stems have potential as antibacterial.
Co-Authors Andi Maulana Kamri Andi Nur Alam Amaliah Bayu Putra Fitriana Fitriana Rahmatia S Hi Amin Sitti Amirah Virsa Handayani, Virsa