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All Journal Paediatrica Indonesiana Medica Hospitalia
Hendra Widjaja
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Pengaruh Pemberian Vitamin C Terhadap Aktiitas Fagositosis Makrofag dan Kadar Vitamin C dalam Cairan Intraperitoneal Mencit Balb/C dengan Sepsis Hendra Widjaja; Ign Riwanto; Edi Dharmana
Medica Hospitalia : Journal of Clinical Medicine Vol. 1 No. 2 (2012): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (824.569 KB) | DOI: 10.36408/mhjcm.v1i2.57

Abstract

Latar belakang : Sepsis masih menjadi permasalahan dalam praktek klinis karena angka mortalitas masih tinggi. Penelitian bertujuan mengetahui pengaruh dosis bertingkat vitamin C yang dibutuhkan untuk mencapai aktivitas fagositosis optimal makrofag mencit sepsis. Metode : Penelitian ini merupakan uji laboratoris mencit Balb/C dengan pendekatan the post test only controlled group design, 20 ekor mencit sepsis dibagi 4 kelompok: kelompok kontrol (K); kelompok perlakuan mendapat vitamin C 0,52 mg/hari (P1); vitamin C 1,04 mg/hari (P2); vitamin C 2,6 mg /hari (P3) selama 3 hari, kemudian diperiksa kemampuan fagositosis makrofag dan kadar vitamin C intraperitoneal. Tingkat aktivitas fagositosis makrofag dan kadar vitamin C intraperitoneal dianalisis dengan ANOVA dilanjutkan dengan Bonferroni test, dan korelasi keduanya diuji dengan uji korelasi Spearman. Hasil : Terdapat perbedaan bermakna pada kemampuan fagositosis makrofag dalam kelompok (p<0,05). Uji antar kelompok menunjukkan: K–P1 (p<0,001), K–P2 (p<0,001), K–P3 (p<0,001), P1–P2 (p<0,001), P1–P3 (p<0,001), tetapi tidak didapatkan perbedaan yang bermakna antara P2-P3 (p=0,48). Terdapat perbedaan bermakna kadar vitamin C intraperitoneal K–P2 (p<0,001), K–P3 (p<0,001), P1–P2 (p=0,003), P1–P3 (p<0,001), P2-P3 (p<0,001), kecuali pada kelompok K–P1 (p=0,131). Didapatkan korelasi positif antara kadar vitamin C intraperitoneal dengan fagositosis makrofag (r=0,58 ; p<0,001). Simpulan : Terdapat peningkatan signifikan pada fagositosis makrofag dan kadar vitamin C intraperitoneal pada mencit Balb/C dengan sepsis yang diberi vitamin C. Dosis ideal vitamin C adalah 1,04 mg/hari, dan kadarnya meningkat sesuai dosis yang diberikan. Kata kunci: Sepsis, vitamin C, fagositosis makrofag, vitamin C intraperitoneal.
Effect of dengue hemorrhagic fever on thrombomodulin level Hendra Widjaja; Max F. J. Mantik
Paediatrica Indonesiana Vol 49 No 5 (2009): September 2009
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (117.547 KB) | DOI: 10.14238/pi49.5.2009.259-63

Abstract

Background Thrombocyte and endothelial cells play animportant role in dengue hemorrhagic fever pathogenesis.Thrombomodulin is a part of glycoprotein membrane inendothelial cells. Therefore, thrombomodulin level willincrease if endothelial cells disruption occurs.Objective To acknowledge the correlation between thedegree of dengue hemorrhagic fever and thrombomodulinlevel.Methods This was a cross-sectional study. Subjects werehospitalized pediatric patients with age ranging from oneto 13 year old in pediatric ward at Pro£ Dr. R.D. KandouHospital, Manado, who had fever. Three milliliters of bloodwere taken from vein, and were divided for two tests whichwere routine blood analysis and thrombomodulin analysis.Different data resulted from the dengue hemorrhagic fevergroup were processed, and analyzed statistically using F Testand LSD (least significant difference) test. The relationbetween dengue hemorrhagic fever and thrombomodulinwas analyzed with Spearman correlation coefficient.Results There was a significant result in the difference ofthrombomodulin level on four dengue hemorrhagic fevergroups which were classified according to the severity ofdengue hemorrhagic fever. There was a very significantpositive correlation between the severity of denguehemorrhagic fever and thrombomodulin level in detectingendothelial cells impairment.Conclusion Thrombomodulin level can be used as amarker to detect endothelial cells impairment in denguehemorrhagic fever. Higher grade of dengue hemorrhagicfever will have higher thrombomodulin level.
Co-Authors Edi Dharmana Ign Riwanto Max F. J. Mantik