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All Journal Jurnal Kreativitas PKM Community Empowerment JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Maria Ulfah
Department Of Histology, Faculty Of Medicine, Universitas Lambung Mangkurat, Banjarmasin
Arts Humanities Education Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : JKKI : Jurnal Kedokteran dan Kesehatan Indonesia

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Antidiabetic potential of karamunting leaves ethanolic extract as a natural herb: Blood glucose levels and pancreatic islets histomorphology on diabetic rats model Ida Yuliana; Asnawati Asnawati; Maria Ulfah; Eko Suhartono
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art9

Abstract

Background: Karamunting leaf is a wetland herb with antioxidant compounds that bind free radicals, reduce oxidative stress, reduce insulin resistance, and prevent the development of pancreatic cell dysfunction and damage.Objective: This study aims to prove the antidiabetic potential of the karamunting leaves ethanolic extract in treating diabetes in white male rats.Methods: This study used a true experimental with a pre-test and post-test control group design. Thirty rats were divided into four groups (control: C, ethanol extract of karamunting dose of 100 mg: P1, 200 mg: P2, and 400 mg: P3). Data on fasting blood glucose levels were taken before (pre-test) and after treatment (post-test). Data on pancreatic islets histomorphological changes (size, number, constituent cells) were analysed quantitatively. Fasting blood glucose levels were analysed using paired t-test, while the histomorphological data of the pancreatic islets were analysed using ANOVA. The data were considered significant if the p-value <0.05 (95% CI).Results: Karamunting leaf ethanol extract treatment reduced fasting blood glucose levels in diabetic rats. A 200 mg/kgBW was demonstrated as the most effective dose that improves the islets and cells number compiles the pancreatic islets, potentially treating diabetes mellitus (DM).Conclusion: Karamunting leaf ethanol extract potential as a natural herbal medicine in treating DM.
Co-Authors Asnawati Asnawati Dewi Indah Noviana Pratiwi Eko Suhartono Endang Pertiwiwati Ida Yuliana Ida Yuliana Irfan Maulana Kandria Firsta Salsabilla Lena Rosida M Kholilurahman M. Febriansyah Mudrikah Khilda Noor Nurhkalisa Putri Azzahra