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All Journal Journal of Health Science and Prevention Gema Kesehatan
Varennia Bhargah
Udayana University
Health Professions Medicine & Pharmacology Nursing Public Health

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Anti-proliperative and Anti-metastatic Agents of Balinese Long Pepper (Piper retrofractum V) Extract in Breast Cancer Made Violin Weda Yani; Varennia Bhargah; I Gede Agus Darsana Palgunadi; Ni Putu Sri Indrani Remitha; I Made Winarsa Ruma
Journal of Health Science and Prevention Vol. 4 No. 1 (2020): JHSP Vol 4 No 1 - 2020
Publisher : State Islamic University of Sunan Ampel

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1305.763 KB) | DOI: 10.29080/jhsp.v4i1.258

Abstract

Breast cancer is malignancy that becomes significant health problem in the world. According to WHO data in 2018, there were 2.1 million cases of breast cancer with mortality rate reaching 627,000. Current breast cancer treatments are surgery, radiation therapy, hormonal therapy and chemotherapy. However, these treatments have side effects such as neuropathy, fatigue after undergoing chemotherapy, and alopecia. Natural ingredients are the choice to overcome these weaknesses, one of which is the utilization of piperine in Balinese long pepper (Piper retrofractum Vahl). Piperine can increase the bioavailability of many drugs by increasing absorption from the intestine, suppressing the metabolism of drugs in lung and liver tissue by inhibiting CYP3A4 and P84 glycoprotein P84. Piperine is easily absorbed in the intestine and excreted through urine and feces, causing minimal toxic effects. Piperine in Balinese long pepper is able to reduce breast cancer cell proliferation by 40%. Piperine can also inhibit epidermal growth factor (EGF) by inducing decreased expression of MMP-9 and MMP-13. Piperine will work through inhibition of NF-κB and PKCα phosphorylation and AP-1 activation by interfering extracellular signal-regulated kinase (ERK) signaling pathway (ERK) 1/2, p38 MAPK, and Akt which results in inhibition of migration and metastasis of breast cancer cells.
POTENSI EKSTRAK BAWANG HITAM SEBAGAI ANTITUBERKULAR MYCOBACTERIUM TUBERCULOSIS Elvina Veronica; Putu Srinata Dampati; Varennia Bhargah; Ni Kadek Sinta Dwi Chrismayanti
GEMA KESEHATAN Vol. 13 No. 1 (2021): Juni 2021
Publisher : POLTEKKES KEMENKES JAYAPURA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47539/gk.v13i1.163

Abstract

Penyakit tuberkulosis (TBC) disebabkan oleh adanya bakteri Mycobacterium tuberculosis (M.tuberculosis). Indonesia termasuk delapan negara dengan kasus TBC tertinggi di dunia (8% kasus). Banyaknya obat TBC dan durasi konsumsi obat yang lama seringkali menjadi alasan tidak tuntasnya obat TBC yang dikonsumsi sehingga terjadi kasus Multidrug Resistant (MDR) strain M. tuberculosis terhadap obat TBC. Saat ini, sekitar 45% kasus TBC sudah mengalami MDR. Bawang hitam merupakan fermentasi bawang putih selama 21 hari pada kelembaban 90% dan suhu 70OC sehingga warna, bau, dan rasa pada bawang menajadi manis keasaman. Studi bertujuan untuk mengetahui potensi ekstrak bawang hitam sebagai antitubercular M.tuberculosis. Studi merupakan studi tinjauan pustaka dengan mencari artikel terkait menggunakan kata kunci dalam 10 tahun terakhir pada browser Google Scholar, Pubmed, NCBI, Garuda. Bawang hitam memiliki antioksidan dan senyawa sulfur lebih tinggi dibandingkan bawang putih serta bersifat hepatoprotektor. Bawang hitam memiliki sifat antituberkular karena mengandung antioksidan dan sulfur yang dapat mengganggu proses metabolisme bakteri, menghambat proses transkripsi protein bakteri, mengaktifkan makrofag yang akan memfagositosis bakteri sehingga menghambat pertumbuhan serta menimbulkan kematian bakteri M.tuberculosis. Perlu studi lebih lanjut terkait dosis ekstrak yang diperlukan serta uji toksisitas.
Co-Authors Elvina Veronica I Gede Agus Darsana Palgunadi I Made Winarsa Ruma Made Violin Weda Yani Ni Kadek Sinta Dwi Chrismayanti Ni Putu Sri Indrani Remitha Putu Srinata Dampati