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All Journal Althea Medical Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Dolvy Girawan
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Medicine & Pharmacology

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Antibacterial Effect of Pulsatilla chinensis towards Staphylococcus aureus, Shigella dysenteriae, and Salmonella typhi Fong, Sim Chee; Mulyana, Yanti; Girawan, Dolvy
Althea Medical Journal Vol 3, No 2 (2016)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (157.154 KB)

Abstract

Background: Pulsatilla (P.) chinensis is a kind of traditional Chinese medicine (TCM) that has antibacterial effect. It is used to treat diarrhea, dysentery, and other diseases. The P. chinensis is composed of some potent antibacterial substances including protoanemonin, saponin, oleanolic acid. The study aimed to determine the antibacterial effect of P. chinensis towards staphlococcus aureus, Shigella dysenteriae, and Salmonella typhi.Methods: This was an experimental descriptive study that was conducted in 2014 using two methods, diffusion and dilution method. In diffusion method, 5 holes were made on the agar that bacteria were growing and different concentrations of P. chinensis infusion were placed in different hole. The inhibitory effect was measured by the inhibition zone. In dilution method, 8 test tubes with decreasing concentration of P. chinensis infusion were mixed with the bacteria suspension and Mueller Hinton Solution. The minimal inhibitory concentration (MIC) was measured by the last clear test tube. The test tube with solution that showed absence of bacteria on culture indicated the minimal bactericidal concentration (MBC).Results: In diffusion method, P. chinensis infusion showed inhibitory effect towards S. aureus and bacteriostatic effect towards S. dysenteriae and S. typhi. In dilution method, there was no antibacterial activity detected.Conclusions: P. chinensis infusion has inhibitory effect on S. aureus and bacteriostatic effect on S. dysenteriae and S. typhi. [AMJ.2016;3(2):292–5]DOI: 10.15850/amj.v3n2.467
Effect of Mangosteen Pericarp Extract on Gastric Mucosal Damage Induced by Aspirin Budiono, Jansen; Achadiyani, Achadiyani; Girawan, Dolvy
Althea Medical Journal Vol 3, No 3 (2016)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (141.697 KB)

Abstract

Background: Peptic ulcer disease is commonly found in the community. Nonsteroidal anti-inflammatory drug (NSAID) such as aspirin is one of the predisposing factors to ulcers. According to various studies, plant extracts have been shown to produce promising results in the treatment of peptic ulcers. Xanthone, the active substance contained in the mangosteen pericarp extract has been extensively studied for its role in various diseases. The present study was undertaken to identify the effect of mangosteen pericarp extract on gastric mucosal damage.Methods: This study was carried out from September−November 2014 in the Animal Laboratory of the Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung. Thirty two rats were randomly divided into 2 groups with different treatments and were induced by aspirin. Histologic studies were conducted to determine the score of gastric mucosal damage. The parameters used were Wattimena’s criteria for damage of gastric mucosa. Data was analyzed using Chi Square test and the outcome was measured in relative risk.Results: The study revealed a significant association between pretreatment with mangosteen pericarp extract and incidence of gastric mucosal damage induced by aspirin (p < 0.05). Calculation with a modified 2 × 2 table revealed a relative risk of 0.625.Conclusions: Rats pretreated with mangosteen pericarp extract exhibit less gastric mucosal damage, in experimentally aspirin-induced ulcer. [AMJ.2016;3(3):388–91] DOI: 10.15850/amj.v3n3.885
Antibacterial Effect of Pulsatilla chinensis towards Staphylococcus aureus, Shigella dysenteriae, and Salmonella typhi Sim Chee Fong; Yanti Mulyana; Dolvy Girawan
Althea Medical Journal Vol 3, No 2 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (33.93 KB)

Abstract

Background: Pulsatilla (P.) chinensis is a kind of traditional Chinese medicine (TCM) that has antibacterial effect. It is used to treat diarrhea, dysentery, and other diseases. The P. chinensis is composed of some potent antibacterial substances including protoanemonin, saponin, oleanolic acid. The study aimed to determine the antibacterial effect of P. chinensis towards staphlococcus aureus, Shigella dysenteriae, and Salmonella typhi.Methods: This was an experimental descriptive study that was conducted in 2014 using two methods, diffusion and dilution method. In diffusion method, 5 holes were made on the agar that bacteria were growing and different concentrations of P. chinensis infusion were placed in different hole. The inhibitory effect was measured by the inhibition zone. In dilution method, 8 test tubes with decreasing concentration of P. chinensis infusion were mixed with the bacteria suspension and Mueller Hinton Solution. The minimal inhibitory concentration (MIC) was measured by the last clear test tube. The test tube with solution that showed absence of bacteria on culture indicated the minimal bactericidal concentration (MBC).Results: In diffusion method, P. chinensis infusion showed inhibitory effect towards S. aureus and bacteriostatic effect towards S. dysenteriae and S. typhi. In dilution method, there was no antibacterial activity detected.Conclusions: P. chinensis infusion has inhibitory effect on S. aureus and bacteriostatic effect on S. dysenteriae and S. typhi. [AMJ.2016;3(2):292–5]DOI: 10.15850/amj.v3n2.467
Effect of Mangosteen Pericarp Extract on Gastric Mucosal Damage Induced by Aspirin Jansen Budiono; Achadiyani Achadiyani; Dolvy Girawan
Althea Medical Journal Vol 3, No 3 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (141.697 KB)

Abstract

Background: Peptic ulcer disease is commonly found in the community. Nonsteroidal anti-inflammatory drug (NSAID) such as aspirin is one of the predisposing factors to ulcers. According to various studies, plant extracts have been shown to produce promising results in the treatment of peptic ulcers. Xanthone, the active substance contained in the mangosteen pericarp extract has been extensively studied for its role in various diseases. The present study was undertaken to identify the effect of mangosteen pericarp extract on gastric mucosal damage.Methods: This study was carried out from September−November 2014 in the Animal Laboratory of the Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung. Thirty two rats were randomly divided into 2 groups with different treatments and were induced by aspirin. Histologic studies were conducted to determine the score of gastric mucosal damage. The parameters used were Wattimena’s criteria for damage of gastric mucosa. Data was analyzed using Chi Square test and the outcome was measured in relative risk.Results: The study revealed a significant association between pretreatment with mangosteen pericarp extract and incidence of gastric mucosal damage induced by aspirin (p < 0.05). Calculation with a modified 2 × 2 table revealed a relative risk of 0.625.Conclusions: Rats pretreated with mangosteen pericarp extract exhibit less gastric mucosal damage, in experimentally aspirin-induced ulcer. [AMJ.2016;3(3):388–91] DOI: 10.15850/amj.v3n3.885
The Effectiveness of Emergency Endoscopic Retrograde Cholangiopancreatography in Patients with Severe Acute Cholangitis Muhammad Begawan Bestari; Nenny Agustanti; Yelica Rachmat; Dolvy Girawan; Ali Djumhana; Juke Roslia Saketi; Siti Aminah Abdurachman
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 11, NUMBER 3, December 2010
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/1132010128-131

Abstract

Background: The aim of this study was to assess the frequency, indications, yield and outcome of emergent endoscopy retrograde cholangiopancreatography (ERCP) in severe acute cholangitis patients. Method: Records of all cholangitis patients undergoing ERCP were reviewed over a six months period. Indications, findings, therapeutic interventions and survival were analyzed. Indications for urgent drainage were temperature greater than 38ºC, increasing abdominal pain, jaundice and any organ involvement. Results: Of 80 ERCPs, 19 (23.75%) were severe acute cholangitis patients underwent emergency ERCP. The common bile duct was the duct of interest in all patients and was cannulated in 100%. The most common findings were choledocholithiasis (42.1%) and pancreatic head cancer (42.1%), followed by cholangiocarcinoma (10.5%) and papil vater carcinoma (5.3%). There were 12 (63.2%) septic shock patients with systolic blood pressure less than 90 mmHg and heart rate greater than 90 beats/minute who required inotropic drugs. Endoscopic biliary drainage was performed using 8.5 F biliary stent (73.7%) or common bile duct (CDB) stones removal (26.3%). The overall 30 days mortality was 0. Conclusion: Emergency ERCP in severe acute cholangitis is associated with improvement of clinical and some laboratory parameters without a complication of acute pancreatitis. In cases of chIoledocholithiasis, it can be performed with stone extraction as well as stent insertion   Keywords: severe acute cholangitis, emergent ERCP, endoscopic stenting in difficult hilar biliary stricture
Tuberculous Splenic Abscesses as an Etiology in Prolonged Fever Dolvy Girawan; S A Abdurachman; Iman Supandiman; Hadi Jusuf; Tan Siauw Koan; Warko Karnadihardja
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 6, ISSUE 3, December 2005
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/63200588-90

Abstract

Extra-pulmonary tuberculosis covers all forms of tuberculosis in which the disease process occurs outside the lungs. Tuberculosis is one of the common infectious causes of splenic enlargement, but tuberculous splenic abscess is a rare presentation. We report the finding of tuberculous multiple splenic abscesses in a young male patient aged 33 years with prolonged fever. The main clinical feature was fever for 6 months prior to admission. Abdominal ultrasound revealed the spleen was normal in size but showed multiple abscesses. CT scan abdomen showed splenomegaly with multiple solid nodules. Patient underwent laparatomy and splenectomy, the spleen indeed showed multiple abscesses. Histopatology Result showed Langhan’s multi nucleated giant cells, caseous necrosis. The patients was diagnosed to have tuberculous multiple abscesses of the spleen. The patient was started  on  daily  short-course  antituberculosis  drugs  with  isoniazid,  rifampicin, pyrazinamide and ethambutol. He responded well to oral antituberculosis treatment.   Keywords: prolonged fever, abdominal ultrasound, CT scan abdomen, tuberculosis, multiple splenic abscesses, splenectomy
Co-Authors Achadiyani Agustanty, Nenny Ali Djumhana Ali Djumhana Bestari, Begawan Dewi, Sumartini Eka Surya Nugraha Emmy Hermiyanti Pranggono Fong, Sim Chee Guntur Darmawan Hadi Jusuf Hadi Jusuf Iman Supandiman Iman Supandiman Jansen Budiono Jansen Budiono Juke Roslia Saketi Juke Roslia Saketi Muhammad Begawan Bestari Nenny Agustanti Nenny Agustanti Nugraha, Irvan Pranggono, Emmy Hermiyanti Rudi Wisaksana S A Abdurachman Sim Chee Fong Siti Aminah Abdurachman Siti Aminah Abdurachman Tan Siauw Koan Usman, Stefanie Yuliana Warko Karnadihardja Yanti Mulyana Yanti Mulyana Yelica Rachmat Yudi Wahyudi