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Eko Naning Sofyanita
Poltekkes Kemenkes Semarang
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Hubungan Kadar Hemoglobin dan Kadar Kreatinin Darah pada Pasien Gagal Ginjal Kronik Pasca Transfusi Berulang Eko Naning Sofyanita; Roni Afriansya; Nur Indah Palupi
Jaringan Laboratorium Medis Vol 2, No 2 (2020): November 2020
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v2i2.7030

Abstract

Kidneys are part of the body that has an important role. One of the functions of the kidney is the production of erythropoietin. Erythropoietin stimulates the production of red blood cells. People or patients who have kidney problems can cause anemia. This study aims to determine the relationship between hemoglobin levels and blood creatinine levels in patients with chronic kidney disease after receiving a transfusion. Blood creatinine levels in this study were used as an index to measure kidney function. The study was conducted at the Wira Tamtama Hospital Semarang by taking data on 20 patients in 2020 with chronic kidney disease and taking data on hemoglobin (cut-off 12 g/dL) and serum creatinine (cut-off 1.5 mg/dL). The relationship between the two was calculated by chi-square test and found 80% of patients with low hemoglobin in patients with high creatinine levels and 0% of patients with low hemoglobin in patients with normal creatinine levels (p=0.040). There is a risk of decreased hemoglobin levels (OR = 3,442) in patients with high creatinine levels. It was concluded that there was a significant relationship between hemoglobin levels and blood creatinine levels and patients with high creatinine levels tended to be at risk of anemia.
The Effect of Light Exposure to Bilirubine Levels on Serum Jaundice Infant in Hospital of Islamic NU Demak Eko Naning Sofyanita; Endang Susilowaty; Roni Afriansya
Borneo Journal of Medical Laboratory Technology Vol 3 No 1 (2020): Borneo Journal of Medical Laboratory Technology
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjmlt.v3i1.1766

Abstract

Bilirubin is a substance formed from the normal breakdown of erythrocytes in the body so that it gives a yellow color to the stool and urine. The test of bilirubin in the laboratory must avoid exposure to light, which can cause decreased serum bilirubin levels by up to 50% in 1 hour due to disruption of the bilirubin's stability. This study is a cross-sectional analytic study of primary data using 30 samples of jaundice baby serum and direct and total bilirubin test. Data collection was conducted from the primary data by a direct test using 40 samples of infant jaundice and test of direct bilirubin and total bilirubin using methods Dichlorophenyl Diazonium. The results of the tests of 40 samples can result in the mean levels of total bilirubin were exposed to the light of 8.58 mg/dl and were not exposed to light 12,67mg /dl. Direct bilirubin levels mean that exposure to light is 3.98 mg/dl. In contrast, the unexposed light of 8.71 mg/dl, so that it can be concluded that the levels of total and direct bilirubin in serum jaundice infants exposed to lower light compared with those not exposed to light.
Hubungan Jumlah Eritrosit dan Hitung Jenis Leukosit pada Masyarakat dengan Paparan Polutan Tinggi di Desa Tambak Mulyo Kota Semarang Eko Naning Sofyanita; Hendra Adistia Bangkit; Roni Afriansya
Borneo Journal of Medical Laboratory Technology Vol 3 No 2 (2021): Borneo Journal of Medical Laboratory Technology
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjmlt.v3i2.2230

Abstract

Lead (Pb) and carbon monoxide (CO) are gas components in airborne pollutants due to vehicle fumes or industrial exhaust gases that affect the blood, namely shortening the life span of erythrocytes produced in erythropoiesis. In addition, small pollutants can be inhaled and enter the alveoli and then phagocytosis and trigger the release of mediators, namely leukocyte cells, which can cause inflammation. This study aims to determine the correlation between the erythrocytes count and differential leucocyte count of the Tambak Mulyo village community, Semarang City. This research was a cross-sectional analytic study of primary data using 20 blood samples, carried out by the erythrocytes count and differential leucocyte count tests. The examination results showed that the average erythrocytes count in all samples was 5.25 million cells/mm3 with a percentage of the normal erythrocytes count is 45.00%, and a high of erythrocytes count is 55.0%. On the test of the differential leucocyte count, 4 samples are obtained with specific values. Normal leukocytes and as many as 16 samples experienced an increase and decrease in the differential leucocyte count. The chi-square test shows Asymp.Sig> 0.05, which means there is no correlation between variables, so it can be concluded that there is no significant correlation between the erythrocytes count and differential leucocyte count (lymphocytes, basophils, eosinophils, neutrophils, and monocytes) in the community with exposure to high pollutants in Tambak Mulyo village, Semarang City.
Correlation Of Erythrocyte Sedimentation Rate (ESR) and Lymphocyte Counts in Pulmonary Tuberculosis Patients during Intensive Treatment in Purwokerto City Eko Naning Sofyanita
Borneo Journal of Medical Laboratory Technology Vol 4 No 1 (2021): Borneo Journal of Medical Laboratory Technology
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjmlt.v4i1.2722

Abstract

Pulmonary tuberculosis is a disease caused by the bacterium Mycobacterium tuberculosis which most often attacks the lungs by spreading through the air in patients who cough, sneeze or spit. In tuberculosis, the erythrocyte sedimentation rate examination is used to help diagnose the course of the disease and help for the success of chronic therapy, and the examination of the lymphocyte count is used to support the diagnosis of bacterial infection. This study is an analytic study through a cross-sectional approach with the Pearson Correlation test. The results of this LED examination were 8 samples (21%) normal and 30 samples (79%) abnormal. On examination of the lymphocyte count, 21 samples (55%) had lymphopenia, 16 samples (42%) were normal patients, and 1 sample (3%) had lymphocytosis. In the Pearson correlation test, the correlation is unidirectional but moderately or moderately correlated (r=0.304). Based on these results, it can be concluded that there is a relationship between erythrocyte sedimentation rate and lymphocyte count. This means that if the LED value is large, the number of lymphocytes will also increase.
Profile of Lymposites in New Tuberculosis (TB) Patients in Semarang City Roni Afriansya; Nurul Qomariyah; Anung Sugihartono; Eko Naning Sofyanita
Jurnal Surya Medika (JSM) Vol. 8 No. 3 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v8i3.3681

Abstract

The body's form of defense or natural immune response against intracellular bacteria is phagocytosis. Cells capable of phagocytosing macrophages in natural responses play a role in presenting antigens to lymphocytes in specific immune responses. The number of lymphocytes associated with the incidence of death in TB patients in hospitals. This study aims to determine the lymphocyte profile in pulmonary TB patients with new cases in the city of Semarang in 2020. This study uses a descriptive-analytic research design. The population in this study were new cases of pulmonary TB patients at the Semarang Health Center in 2020. The sample in this study was new cases of pulmonary TB patients at the Semarang Health Center from September to October 2020. The results showed that the newest cases of pulmonary TB were male (59%), and based on age the most were productive age (87.8%), and the lymphocyte profile of 78% of respondents had relative lymphopenia, 19.5% of respondents were normal and 2.4% of respondents experienced relative lymphocytosis. Overall, it can be said that the profile of patients with lymphopenia is 14.63%, and relative lymphopenia is 78%.
PENGARUH PENGGUNAAN MINYAK ZAITUN DENGAN PEMANASAN SEBAGAI LARUTAN PENJERNIH (CLEARING) TERHADAP KUALITAS SEDIAAN JARINGAN HEPAR MENCIT (Mus musculus) Eko Naning Sofyanita; Anna Sufi Annisa
Jurnal Labora Medika Vol 7, No 1 (2023)
Publisher : Program Studi Teknologi Laboratorium Medik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jlabmed.7.1.2023.%p

Abstract

Tahap penjernihan merupakan salah satu langkah penting histoteknik yang mana xylene digunakan sebagai larutan penjernih rutin, namun paparan jangka pendek xylene memiliki efek toksik bagi penggunanya. Minyak zaitun merupakan larutan alternatif pengganti xylene dengan kelebihan salah satunya bersifat tidak beracun. Penelitian ini menerapkan prinsip Bernoulli dengan pemanasan bertujuan untuk menurunkan viskositas larutan dan mempercepat proses penjernihan. Tujuan penelitian ini untuk mengetahui pengaruh penggunaan minyak zaitun dengan pemanasan sebagai larutan penjernih (clearing) terhadap kualitas sediaan hepar mencit (Mus musculus). Metode penelitian ini Eksperimental dan desain penelitian cross sectional dengan dua kelompok perlakuan yaitu penjernihan menggunakan xylene dan minyak zaitun dengan pemanasan, kemudian preparat diwarnai menggunakan Hematoxylin-eosin lalu diamati kualitas mikroskopisnya. Data diolah menggunakan uji statistik Mann Whitney. Hasil penelitian menunjukkan normalitas data (p=0.000) dengan sebaran tidak normal dan uji Mann Whitney (p=0.382) ada perbedaan. Kualitas preparat kelompok xylene dengan pemanasan suhu 37°C didapatkan preparat baik 5 (100%) dengan rata-rata skor lapang pandang 8.44, sedangkan pada kelompok minyak zaitun dengan pemanasan suhu 45°C diperoleh kualitas preparat baik 5 (100%) dengan rata-rata skor lapang pandang 7.16. Kesimpulan penelitian ini yaitu minyak zaitun dengan pemanasan berhasil menjernihkan jaringan dengan baik dan menghasilkan kualitas sediaan yang hampir setara kualitasnya menggunakan xylene dengan pemanasan..
Efektifitas Penggunaan Deterjen Laundry Cair sebagai Agen Deparafinisasi pada Sediaan Ginjal Mencit (Mus musculus): Effectiveness of Using Liquid Laundry Detergent as a Deparaffinizing Agent in Mice Kidney Preparations Faiz Shofa Abdillah; Eko Naning Sofyanita
Borneo Journal of Medical Laboratory Technology Vol. 5 No. 2 (2023): Borneo Journal of Medical Laboratory Technology
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjmlt.v5i2.5100

Abstract

Deparaffinization is one of the stages of tissue processing, which aims to dissolve paraffin for full-color application. Deparaffinization can only be done by xylol to dissolve paraffin as fat. Liquid laundry detergent has the main component in the form of a surfactant which has the property of removing types of lipids by dissolving and emulsification because xylol has carcinogenic properties, flammable properties, and is relatively expensive. This study aimed to describe the quality of tissue preparations using liquid laundry detergents 1.5%, 3%, and 4.5% as deparaffinized agents and also to describe and compare several concentrations of the most effective laundry detergents as deparaffinized agents. Results from the preparation quality using xylol as a deparaffinized agent by conducting an experimental study with a cross-sectional design showed promising results. The quality of preparations using 1.5% liquid laundry detergent got poor results. The quality of preparations using 3% liquid laundry detergent got poor results. The quality of preparations using 4.5% liquid laundry detergent got good results. Based on the results of the Kurskal Wallis test with a significance value of p <0.05, which indicates that H0 is rejected, the conclusion that can be drawn is that there is an unfavorable difference in results between xylol and liquid laundry detergent as a deparaffinized agent.
Hasil Uji Quality Control Produk Fresh Frozen Plasma (FFP) Di UDD PMI Kota Semarang Tahun 2022 I Made Wisnu Darma Putra; Eko Naning Sofyanita
Jurnal Dunia Ilmu Kesehatan (JURDIKES) Vol. 1 No. 1 (2023): JURDIKES - JUNI
Publisher : PT. Padang Tekno Corp

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59435/jurdikes.v1i1.87

Abstract

Darah dan produk darah berperan penting dalam pelayanan kesehatan, sehingga harus dijamin dengan sistem manajemen mutu yang baik. Untuk memastikan bahwa produk darah sesuai dengan standar mutunya dengan melakukan Quality Control produk darah salah satunya produk Fresh Frozen Plasma. Produk FFP dinyatakan lulus QC jika memenuhi 5 parameter pemeriksaan yaitu, volume, faktor VIII, residual cells, kebocoran dan perubahan visual. Jenis penelitian yang digunakan adalah deskriptif dengan pendekatan retrospektif. Pengambilan sampel dengan metode random sampling sebanyak 1% dari total produk FFP di UDD PMI Kota Semarang Tahun 2022. Hasil kelulusan QC FFP tahun 2022 yang diperoleh dari 48 sampel yaitu 48 sampel (100%) untuk volume, 41 sampel (85%) untuk faktor VIII, 48 sampel (100%) untuk residual cells, 48 sampel (100%) untuk kebocoran dan 48 sampel (100%) untuk perubahan visual. Hasil QC FFP secara keseluruhan yang lulus selama satu tahun sebanyak 41 sampel (85%). Produk FFP di UDD PMI Kota Semarang pada tahun 2022 memiliki kualitas yang baik sesuai dengan standar 5 parameter pemeriksaan, yaitu volume, faktor VIII, residual cells, kebocoran kantong dan perubahan visual.
Gambaran Nilai Hematokrit Sebelum Dan Sesudah Donor Darah Di UDD PMI Kabupaten Cilacap Aniesa Izzatun Nafsi; Eko Naning Sofyanita
Jurnal Dunia Ilmu Kesehatan (JURDIKES) Vol. 1 No. 1 (2023): JURDIKES - JUNI
Publisher : PT. Padang Tekno Corp

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59435/jurdikes.v1i1.90

Abstract

Donor darah merupakan tahap pengambilan darah dari seseorang secara sukarela dan disimpan di bank darah sebagai stok darah yang nanti dipakai untuk mentransfusikan darah. Hematokrit (Hct) adalah persentase jumlah sel darah merah atas jumlah keseluruhan darah. Nilai normal untuk pria 40-48% dan untuk wanita 37-43%. Nilai hematokrit dapat digunakan sebagai tes skrining sederhana untuk anemia, sebagai referensi kalibrasi untuk metode otomatis hitung sel darah dan membimbing keakuratan pengukuran hemoglobin. Mengetahui hasil nilai hematokrit sebelum dan sesudah donor darah di UDD PMI Kabupaten Cilacap. Jenis penelitian ini adalah quasi experimental dengan kriteria penelitian deskriptif serta menggunakan pendekatan cross sectional dan menggunakan data primer. Berdasarkan hasil penelitian, sebanyak 30 responden yaitu sebelum donor darah didapatkan paling tinggi yaitu jenis kelamin laki-laki dengan kategori normal sebanyak 16 pendonor (53,3%), sedangkan sesudah donor didapatkan paling tinggi yaitu jenis kelamin laki-laki dengan kategori normal sebanyak 15 pendonor (50%). Sebelum donor darah berdasarkan usia didapatkan pendonor terbanyak berusia 22-44 tahun (dewasa) memiliki nilai Hct normal sebanyak 13 pendonor (43,4%) dan sesudah donor pendonor terbanyak berusia 22-44 tahun (dewasa) memiliki nilai Hct normal sebanyak 10 pendonor (33,3%). Penelitian yang dilakukan di UDD PMI Kabupaten Cilacap dengan total 30 responden disimpulkan bahwa rata-rata nilai hematokrit sebelum donor darah adalah 43,3% dan sesudah donor darah adalah 40,2%. Jadi tidak ada hubungan nilai hematokrit dengan sebelum dan sesudah donor darah.
Gambaran Bakteri Escherichia Coli Pada Jajanan Gorengan Di Sepanjang Jalan Tlogosari Raya Semarang Errina Septiyasari; Eko Naning Sofyanita
Jurnal Dunia Ilmu Kesehatan (JURDIKES) Vol. 1 No. 1 (2023): JURDIKES - JUNI
Publisher : PT. Padang Tekno Corp

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59435/jurdikes.v1i1.98

Abstract

Gorengan merupakan makanan yang digoreng menggunakan minyak. Lokasi pedagang gorengan di sepanjang Jalan Tlogosari Raya Semarang yang berada di pinggir jalan dan kurangnya perhatian pedagang terhadap kebersihan dapat menimbulkan kontaminasi kuman terhadap gorengan. Salah satu bakteri yang potensial mencemari makanan adalah Escherichia coli.  E coli merupakan flora normal berbentuk batang gram negatif di dalam saluran pencernaan hewan dan manusia. Bakteri E coli  dapat berasifat patogen jika jumlah bakteri dalam saluran pencernaan meningkat atau berada di luar usus. Penelitian ini merupakan penelitian observasional dengan kriteria penelitian deskriptif melalui pendekatan cross sectional. Hasil Penelitian yang didapat Dari 7 sampel yang diperiksa, sebanyak 1 sampel (14,29%) tercemar bakteri Escherichia coli, dan 6 sampel (75%) lainnya tidak tecemar  bakteri Escherichia coli. Satu sampel tersebut tidak sesuai dengan Peraturan Menteri Kesehatan Republik Indonesia No. 1096/Menkes/Per/VI/2011 karena mengandung bakteri Escherichia coli > 0/gram sampel makanan. Dari hasil observasi didapatkan sebanyak 1 sampel (14,29%) pedagang gorengan yang mempunyai kriteria tingkan hygiene dan sanitasi yang baik. Sedangkan 6 sampel (85,71%) lainnya memiliki kriteria tingkat hygiene dan sanitasi yang sedang.
Co-Authors Aniesa Izzatun Nafsi Anna Sufi Annisa Anung Sugihartono Endang Susilowaty Errina Septiyasari Faiz Shofa Abdillah Hendra Adistia Bangkit I Made Wisnu Darma Putra Lilik Setyowatiningsih Nur Indah Palupi Nurul Qomariyah Rihanesa Diana Putri Ririh Jatmi Wikandari Roni Afriansya