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All Journal Jurnal Kedokteran Syiah Kuala Citra Delima Scientific journal of Citra Internasional Institute Journal of Health Science Citra Delima Scientific journal of Citra Internasional Institute
Precelia Fransiska
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Health Professions Medicine & Pharmacology Nursing Public Health

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HUBUNGAN POLIMORFISME GEN CATECHOL-O-METHYLTRANSFERASE (COMT) VAL158MET DENGAN KEJADIAN MIOMA UTERI PADA ETNIS MELAYU DI SUMATERA SELATAN Precelia Fransiska; Ferry Yusrizal; Legiran Legiran
Jurnal Kedokteran Syiah Kuala Vol 18, No 3 (2018): Volume 18 Nomor 3 Desember 2018
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v18i3.18014

Abstract

Abstrak. Objektif : Untuk mengetahui distribusi karakteristik sosiodemografi, genotip dan alel polimorfisme gen Catechol-O-Methyltransferase (COMT) Val158Met dengan kejadian mioma uteri pada etnis Melayu di Sumatera Selatan. Desain Penelitian : Penelitian ini merupakan analitik observasional dengan desain kasus kontrol (case-control). Penelitian ini dilaksanakan pada bulan November 2018-Januari 2019 dilaboratorium bioteknologi fakultas kedokteran universitas sriwijaya. Sampel penelitian menggunakan sampel darah yang diambil pada 78 sampel yang terdiri dari 39 kasus dan 39 kontrol yang dilakukan dengan metode PCR RFLP. Hasil : Usia, usia saat menarche, riwayat keluarga dan merokok tidak terdapat hubungan yang bermakna sedangkan paritas dan menggunakan kontrasepsi hormonal memiliki hubungan yang bermakna. Genotip positif mioma terdapat 17 responden dan negatif mioma 1 responden dari 78 responden untuk alel guanin terdapat 33 responden dan alel adenin 3 responden. Kesimpulan : Tidak terdapat perbedaan hubungan antara gen Catechol-O-Methyltransferase (COMT) Val158Met dengan kejadian mioma uteri pada etnis Melayu di Sumatera Selatan dikarenakan hasil dari PCR dan RLFP hanya terdapat pemotongan sebanyak 18 responden dari 78 responden sehingga tidak dapat dianalisis menggunakan SPSS karena tidak memenuhi persyaratan uji statistik akan tetapi gen Catechol-O-Methyltransferase (COMT) Val158Met merupakan faktor risiko untuk terjadinya mioma uteri. Kata Kunci: Mioma uteri, Polimorfisme, gen Catechol-O-Methyltransferase (COMT) Val158met Abstract. Objective: to determine the characteristic distribution of sociodemography, genotypes and the polymorphism allele of the Catechol-O-Methyltransferase (COMT) Val158met gene with the incidence of uterine myoma in Malay ethnicity in South Sumatra. Intervention: This study is an observational analytic with case-control design (case-control). This research was conducted in November 2018-January 2019 in the laboratory of molecular biology at the Sriwijaya University medical school. The study sample used blood samples taken in 78 samples consisting of 39 cases and 39 controls carried out by the RFLP PCR method. Results: age, age at menarche, family history and smoking had no significant relationship while parity and hormonal contraception had a significant relationship. Positive myoma genotypes were 17 respondents and negative myoma 1 respondent from 78 respondents for the guanin allele there were 33 respondents and adenin alleles 3 respondents. Conclusion: there is no difference between the relationship between the Catechol-O-Methyltransferase (COMT) Val158met gene and the incidence of uterine myoma in Malay ethnicity in South Sumatra because the results of PCR and RLFP were only 18 respondents from 78 respondents so they could not be analyzed using SPSS because they did not meeting statistical test requirements but the Catechol-O-Methyltransferase (COMT) Val158met gene is a risk factor for the development of uterine myomas.Keywords: uterine myoma, Polymorphism, Catechol-O-Methyltransferase (COMT) Val158met
Hubungan Antara Pengetahuan dan Status Gizi Ibu Hamil dengan Kejadian Pre Eklamsia pada Ibu Hamil Precelia Fransiska
Citra Delima : Jurnal Ilmiah STIKES Citra Delima Bangka Belitung Vol 4 No 1 (2020): Citra Delima: Jurnal Ilmiah STIKES Citra Delima Bangka Belitung
Publisher : STIKES Citra Delima Bangka Belitung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (227.856 KB) | DOI: 10.33862/citradelima.v4i1.100

Abstract

Pre eclamsia every pregnant women Indonesia is prone to hypertension,wich is caused for 48 hours,during preganancy. The purpose this study was to determine is relationship between knowledge, and nutritional status the pregnant women with the incidence of pre-eclampsia, The women pregnant in Prabumulih Country Health Center in 2019. This study uses analytical survey using the cross sectional approach. The population of this were pregnant women who had preeclampsia at Prabumulih country, Health Center. This method take with by doing a test on pregnant women,from the results of research and analysis univariately, from 58 people with detail,36 (62,1%) people with good knowledge, and 20 (34,5%) people not good. From the results above to 29 (50%) people well also nutrished are, and 29 people nutrition have poor. Bivariate analysis showed that Knowledge had a significant relationship with pre-eclampsia (p value 0.006) and Nutritional Status had a significant relationship with the incidence of pre-eclampsia (p value 0.006). The conclusion of this study is that there is a relationship between knowledge and nutritional status of pregnant women with the incidence of pre-eclampsia in pregnant women in the Prabumulih Coutry Health Center 2019.
FAKTOR – FAKTOR YANG BERHUBUNGAN DANGAN MINAT IBU DALAMPEMILIHAN ALAT KONTRASEPSI IUD Precelia Fransiska
JOURNAL OF HEALTH SCIENCE Vol 1 No 1 (2021): Journal Of Health Science
Publisher : LPPM Universitas Kader Bangsa Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (57.026 KB)

Abstract

IUD atau Alat Kontrasepsi Dalam Rahim IUD (AKDR) bagi banyak kaum wanita merupakan alat kontrasepsi yang terbaik. Tujuan penelitian adalah mengetahui faktor-faktor yang berhubungan dengan minat ibu dalam pemilihan alat kontrasepsi IUD. Penelitian ini menggunakan Survey Analitik dengan menggunakan pendekatan Cross Sectional. Populasi penelitian ini adalah ibu yang menggunakan alat kontrasepsi yang berjumlah 46 orang. Sampel berjumlah 46 responden. Pada analisa univariat didapatkan responden dari 46 responden didapatkan bahwa responden yang Berpengetahuan Baik 32 responden (69,6%) dan responden yang Pengetahuannya Kurang 14 responden (30,4%). Dukungan Suami sebanyak 30 responden (65,2%) dan responden yang tidak mendapat dukungan sebanyak 16 responden (34,8%). Kepemilikan BPJS sebanyak 31 responden (67,4%) dan responden yang tidak memiliki BPJS 15 responden (32,6%). Analisa Bivariat menunjukkan Pengetahuan (ρ value 0,000), Dukungan Suami (ρ value 0,000), Kepemilikan BPJS (ρ value 0,000) mempunyai hubungan yang bermakna dengan kontrasepsi IUD. Simpulan dari penelitian ini adalah bahwa ada faktor-faktor yang mempengaruhi dalam memilih kontrasepsi IUD. Kata Kunci : Pengetahuan, Dukungan, BPJS danKontrasepsi IUD
Hubungan Antara Pengetahuan dan Status Gizi Ibu Hamil dengan Kejadian Pre Eklamsia pada Ibu Hamil Precelia Fransiska
Citra Delima Scientific journal of Citra Internasional Institute Vol 4 No 1 (2020): Citra Delima: Jurnal Ilmiah STIKES Citra Delima Bangka Belitung
Publisher : Ilmiah Institut Citra Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (227.856 KB) | DOI: 10.33862/citradelima.v4i1.100

Abstract

Pre eclamsia every pregnant women Indonesia is prone to hypertension,wich is caused for 48 hours,during preganancy. The purpose this study was to determine is relationship between knowledge, and nutritional status the pregnant women with the incidence of pre-eclampsia, The women pregnant in Prabumulih Country Health Center in 2019. This study uses analytical survey using the cross sectional approach. The population of this were pregnant women who had preeclampsia at Prabumulih country, Health Center. This method take with by doing a test on pregnant women,from the results of research and analysis univariately, from 58 people with detail,36 (62,1%) people with good knowledge, and 20 (34,5%) people not good. From the results above to 29 (50%) people well also nutrished are, and 29 people nutrition have poor. Bivariate analysis showed that Knowledge had a significant relationship with pre-eclampsia (p value 0.006) and Nutritional Status had a significant relationship with the incidence of pre-eclampsia (p value 0.006). The conclusion of this study is that there is a relationship between knowledge and nutritional status of pregnant women with the incidence of pre-eclampsia in pregnant women in the Prabumulih Coutry Health Center 2019.
Co-Authors Ferry Yusrizal Legiran Legiran