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All Journal Indonesian Journal of Cancer Chemoprevention
. Harliansyah
Department of Biochemistry, Faculty of Medicine,YARSI University
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Chemopreventive Efficacy of Ginger Extract (Zingiber officinale) Harliansyah, .; Zurinah, W.N. Wan; Anum, M.Y. Yasmin; Azian, M Noor
Indonesian Journal of Cancer Chemoprevention Vol 1, No 2 (2010)
Publisher : Indonesian Research Gateway

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Abstract

The liver cells were cultured in the  presence of ginger extract at various concentrations (0-1 mg /ml) for 24 h and the cells viability and proliferation rate were evaluated by MTS and BrdU assays, while  apoptosis was evaluated by colorimetric determination of caspase 8 and 3 activities.  Ginger extract exhibited a dose dependent inhibition of viability and proliferation of WRL-68, HLE and HepG2 cells with IC50 of 569.69 ± 7.99 µg/ml, 389.71 ± 26.56 µg/ml and 358.71 ±  17.12 µg/ml respectively. Ginger extract induced apoptosis through activation of caspase-8 and 3 in a dose dependent pattern for all cells at concentration ranging from 0-500  μg/ml.  We found that antiproliferative effect of ginger extract could be associated with induction of apoptosis as shown by increased activities of caspase 8 and 3.The results from this study suggest that ginger extract has chemopreventive properties against hepatoma cells HepG2 and HLE by inhibiting cellular proliferation and inducing apoptosis.
Anti-Inflammatory Activity of The Extract of Guava Leaves (Psidium guajava L) in The Rat (Rattus norvegicus L) Weni, Linda; Harliansyah, .; Widayanti, .
Indonesian Journal of Cancer Chemoprevention Vol 2, No 1 (2011)
Publisher : Indonesian Research Gateway

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Abstract

Using of natural sources that have anti-inflammatory activity for the prevention and treatment of degenerative diseases began to be further explored. An investigation on the anti-inflammatory activity of the aqueous extract of guava leaves (Psidium guajava L.) from Sawangan, Depok on white male rats of Sprague-Dawley strain had been carried out on the carrageenan-induced  paw  edema  method.    To  examine  the  effect  of  guava  extract  on subcutan at different doses of 125, 250 and 500 mg/kg of body weight (BW).  Indometacine at dose of 10 mg/kg BW was used as a positive control. Observations were made during five hours with an interval of one hour. These results demonstrate that the percentage of inflammation or edema (% E) optimal at the 4th hour and then decreased at the 5th hour, while the percentage of optimal inhibition occurred at the 5th hour. Guava extract at 125, 250 and 500 mg/kg BW reduced inhibitory percentage activities by 40.81, 55.45 and 43.61% (p<  0.05)  respectively.  In  conclusion,  this  study  suggests  that  guava  extract  has  anti-inflammatory properties by decreasing edema level.
Co-Authors . Widayanti Linda Weni M Noor Azian M.Y. Yasmin Anum W.N. Wan Zurinah