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All Journal The Journal of Pure and Applied Chemistry Research International Journal of Cell and Biomedical Science
Fahimah Martak
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Absorption Activity of Cassava Peel (Manihot utilissima) as Chromium (VI) Metal Biosorbent in Electroplating Waste Iin Candrawati; Fahimah Martak; Yurike Ika Cahyo
The Journal of Pure and Applied Chemistry Research Vol 6, No 2 (2017): Edition of May-August 2017
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (842.514 KB) | DOI: 10.21776/ub.jpacr.2017.006.02.313

Abstract

Electroplating is a process of metal veneering with another metal using the electric energy. The water waste of electroplating industry contains many kinds of heavy metal ions, especially chromium (VI) which might cause pollutions if it was not processed and it presents above the threshold allowed. The use of cellulose can be a solution, because it has the functional groups which form bonding with the metal ions. Cassava peel is one of the sources of cellulose which contains 80-85% of cellulose. This proves that cassava peel (Manihot utilissimaI) has the potential as the heavy metal biosorbent of chromium metal in electroplating waste. The methodology of the research is conducted in a series including analysis of heavy metal concentrations of chromium (VI) in electroplating waste. Biosorption treatment of cassava peel (Manihot utilissimaI) biosorbent activated by HNO3 1.5 M in electroplating waste conducted in the batch method. Analysis of heavy metal concentrations of chromium (VI) in electroplating waste was performed by Atomic Absorption Spectrophotometry (AAS) after biosorbtion process. Variation of biosorbent mass were (0.1, 0.2, 0.3, 0.4, 0.5) grams, and variation of biosorbent contact time were (10, 20, 30, 40, 50) minutes. The analysis result recorded by AAS (Atomic Absorption Spectrophotometry) showed that the level of total chromium in electroplating waste reaches 2.0777 ± 0.2785 ppm. Accordingly, the chromium test solution used in this research was 2 ppm to measure the optimum conditions of % chromium (VI) adsorbed with variation of mass and contact time. From the results of this research, the optimum mass and contact time of cassava peel biosorbent activated by HNO3 1.5 M in % chromium (VI) adsorbed were 0.1 gram and 40 minutes, respectively. Finally, the optimum mass and contact time of cassava peel biosorbent activated by HNO3 1.5 M has applied to electroplating waste. The % chromium adsorbed in electroplating waste with the addition of cassava peel biosorbent activated by HNO3 1.5 M was measured in average of 61.72%. 
Upregulation of P53 Gene Expression on Breast Cancer Stem Cells Treated with Trisindoline 5 Compound Yofinta I Salsabila; Nadia Azhaar; Muhammad Fatoni; Awik P.D. Nurhayati; Shabrina Syifa Ghaissani; Vinda Aprilia Nurul Andifa; Mardi Santoso; Fahimah Martak
International Journal of Cell and Biomedical Science Vol 1 No 2 (2022)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v1i2.20

Abstract

Background: Cancer stem cells (CSCs) are the subpopulation of cancer cells that have been demonstrated as the cause of tumor formation. The most common cancer for women and the second leading cause of death in breast cancer. Numerous genes have been involved in breast cancers, including p53. In cancer cells, p53 as well-known as the tumor suppressor gene plays an important role in directing cells with DNA damage into apoptosis. Trisindolines are heterocyclic nitrogen compounds consisting of an isatin core bearing two indole moieties that provide cytotoxic effects on cancer cells. Recently research had led to the development of the new modification of trisindoline compound into trisindoline 5. Objective: This study aims to investigate the effect of trisindoline 5 compounds against p53 gene expression in CSCs MDA-MB-231 in vitro. Methods: CSCs MDA-MB-231 were divided into control and treatment groups which were further analyzed in gene expression using the qPCR Livak method. Results: Based on gene expression analysis, trisindoline 5 increases the expression of p53 in CSCs MDA-MB-231. Conclusion: This study informed that trisindoline 5 could upregulate the expression of tumor suppressor gene p53 in CSCs MDA-MB-231 in vitro.
Co-Authors Awik P.D. Nurhayati Iin Candrawati Mardi Santoso Muhammad Fatoni Nadia Azhaar Shabrina Syifa Ghaissani Vinda Aprilia Nurul Andifa Yofinta I Salsabila Yurike Ika Cahyo