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All Journal IMAJI Dinamika International Journal of Cell and Biomedical Science
Muhammad Fatoni
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Social Sciences

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REDESAIN SMKN 11 SEMARANG muhammad fatoni; septana bagus pribadi; indriastjario indriastjario
IMAJI Vol 1, No 3 (2012): IMAJI
Publisher : Departemen Arsitektur, Fakultas Teknik, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1195.912 KB)

Abstract

Pada tahun 2007 Depdiknas menargetkan perbandingan atau porsi antara Sekolah Menengah Kejuruan (SMK) sebesar 70% dan Sekolah Menengah Umum (SMA) sebesar 30%. SMKN 11 Semarang merupakan salah satu sekolah menengah kejuruan yang di proyeksikan kedalam sekolah bertaraf internasional, karena itu SMKN 11 Semarang perlu berbenah dalam kurikulum maupun dari segi sarana prasarana pendidikan.Oleh karena itu diperlukan desain sekolah yang memenuhi sekolah bertarap internasional dalam hal ini SMKN 11 Semarang untuk membantu keberlangsungan proses belajar mengajar untuk mencapai visi, misi dan tujuan yang diharapkan sekolah khususnya dan tujuan pendidikan nasional pada umumnya.Redesain ini diawalai dengan kajian mengenai standar-standar kebutuhan Sekolah Betaraf Internasional (SBI), studi banding beberapa sekolah beraraf Internasional khususnya SMK (Sekolah Menengah Kejuruan), Tinjauan Sekolah Menengah Kejuruan Negeri 11 Semarang, studi ruang mengenai kebutuhan sekolah bertaraf Internasional, Analisa Tapak yang dilakukan pada tapak existing yaitu tapak SMKN 11 Semarang yang terletak di Jalan Grafika. Selain itu juga dibahas mengenai tata massa dan ruang bangunan, penampilan bangunan, struktur, sirkulasi, serta utilitas yang dipakai dalam perancangan “Redesain SMKN 11 Semarang”.Konsep perancangan yang digunakan adalah konsep arsitektur Neoverkaular, yaitu aliran yang suatu paham dari aliran Arsitektur Post-Modern yang lahir sebagai respon dan kritik atas modernisme yang mengutamakan nilai rasionalisme dan fungsionalisme yang dipengaruhi perkembangan teknologi industri. Karena bangunan SMKN 11 merupakan bangunan sekolah yang bersifat resmi, maka wujud desain yang ditampakkkan adalah desain dengan kesan formal dengan mempertimbangkan kriteria-kriteria desain sekolah
KEBIJAKAN HUKUM PIDANA DALAM PENANGGULANGAN JUDI ONLINE MENURUT UNDANG-UNDANG NOMOR 19 TAHUN 2016 TENTANG PERUBAHAN ATAS UNDANG-UNDANG NOMOR 11 TAHUN 2008 TENTANG INFORMASI DAN TRANSAKSI ELEKTRONIK Muhammad Fatoni
Dinamika Vol 28, No 18 (2022): Dinamika
Publisher : Fakultas Hukum Universitas Islam Malang

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ABSTRACCriminal law is often used to solve social problems, especially in the fight against crime. One of them is the problem of online gambling as a form of societal ills or a form of social pathology. Thus, one of the rational efforts used to overcome online gambling is the approach of criminal law policy. Therefore, in this study, the formulation of the problem was raised; the first is how the penal policy model is related to online gambling, and the second is how preventive efforts are carried out by law enforcement against online gambling actors. The research method used is juridical-normative with a regulatory approach and related legal materials. As for the results of the research discussed, there is a Law Number 11 of 2008 concerning Information and Electronic Transactions is an alternative to countering online gambling as a criminal crime. Furthermore, through the legal instruments of the Law a quo, it actually provides real restrictions and threats so that people do not gamble online, this is what is called a preventive effort. Key words : Policy, Online Gambling, ITE Law ABSTRAK            Hukum pidana seringkali digunakan untuk menyelesaikan masalah sosial khususnya dalam penanggulangan kejahatan. Salah satunya adalah masalah perjudian online sebagai salah satu bentuk penyakit masyarakat atau satu bentuk patologi sosial. Maka, salah satu usaha rasional yang digunakan untuk menanggulangi perjudian online adalah dengan pendekatan kebijakan hukum pidana. Oleh karenanya, dalam penelitian ini diangkat rumusan masalah; yang pertama, bagaimana model kebijakan penal policy yang berkaitan judi online, dan yang kedua, bagaimana upaya preventif yang dilakukan oleh penegak hukum terhadap pelaku judi online. Metode penelitian yang digunakan adalah yuridis-normatif dengan pendekatan peraturan dan bahan- bahan hukum  terkait. Adapun hasil penelitian yang dibahas, adanya Undang-undang Nomor 11 Tahun 2008 tentang Informasi dan Transaksi Elektronik menjadi alternatif penanggulangan perjudian online sebagai suatu tindak kejahatan bersifat pidana. Selanjutnya, melalui instrumen hukum UU a quo maka sebetulnya memberikan batasan dan ancaman secara nyata agar masyarakat tidak melakukan perjudian melalui online, hal inilah yang disebut sebagai upaya preventif. Kata Kunci: Kebijakan, Judi Online, UU ITE
Trisindoline 5 Compound Inhibits Human Breast Cancer Stem Cell Formation by Downregulating the BCL-2 Gene Expression Muhammad Fatoni; Yofinta I Salsabila; Awik P.D. Nurhayati; Shabrina Syifa Ghaissani; Mardi Santoso; Fahimah Martak
International Journal of Cell and Biomedical Science Vol 1 No 2 (2022)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v1i2.19

Abstract

Background: Breast cancer cell's growth and survival are supported by breast cancer stem cells (bCSCs) mammosphere formation. bCSCs represent a subpopulation of undifferentiated cancer cells which associated with self-renewing abilities, tumor initiation, drug resistance, and metastasis. Overexpression of the B Cell Lymphoma 2 (BCL-2) family in many tumor cells contributes to apoptosis resistance. Trisindoline is an indole trimer alkaloid natural compound that provides a cytotoxic effect on cancer cells. A new modification of trisindoline has been synthesized into trisindoline 5 in 2021. Objective: This study purposed to investigate the effect of trisindoline 5 compounds against BCL-2 gene expression in bCSCs in vitro. Methods: The bCSCs MDA-MB-231 were divided into control and treatment groups which were further analyzed in gene expression using the qPCR Livak method. Results: Based on gene expression analysis, the results showed that trisindoline 5 may decrease the expression of BCL-2 in MDA-MB-231 cells. Conclusion: This study concludes that trisindoline 5 could downregulate the antiapoptotic BCL-2 gene expression in bCSCs in vitro.
Upregulation of P53 Gene Expression on Breast Cancer Stem Cells Treated with Trisindoline 5 Compound Yofinta I Salsabila; Nadia Azhaar; Muhammad Fatoni; Awik P.D. Nurhayati; Shabrina Syifa Ghaissani; Vinda Aprilia Nurul Andifa; Mardi Santoso; Fahimah Martak
International Journal of Cell and Biomedical Science Vol 1 No 2 (2022)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v1i2.20

Abstract

Background: Cancer stem cells (CSCs) are the subpopulation of cancer cells that have been demonstrated as the cause of tumor formation. The most common cancer for women and the second leading cause of death in breast cancer. Numerous genes have been involved in breast cancers, including p53. In cancer cells, p53 as well-known as the tumor suppressor gene plays an important role in directing cells with DNA damage into apoptosis. Trisindolines are heterocyclic nitrogen compounds consisting of an isatin core bearing two indole moieties that provide cytotoxic effects on cancer cells. Recently research had led to the development of the new modification of trisindoline compound into trisindoline 5. Objective: This study aims to investigate the effect of trisindoline 5 compounds against p53 gene expression in CSCs MDA-MB-231 in vitro. Methods: CSCs MDA-MB-231 were divided into control and treatment groups which were further analyzed in gene expression using the qPCR Livak method. Results: Based on gene expression analysis, trisindoline 5 increases the expression of p53 in CSCs MDA-MB-231. Conclusion: This study informed that trisindoline 5 could upregulate the expression of tumor suppressor gene p53 in CSCs MDA-MB-231 in vitro.
Co-Authors Awik P.D. Nurhayati Awik P.D. Nurhayati Fahimah Martak Fahimah Martak Indriastjario Indriastjario Mardi Santoso Nadia Azhaar Septana Bagus Pribadi Shabrina Syifa Ghaissani Vinda Aprilia Nurul Andifa Yofinta I Salsabila