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All Journal Indonesian Journal of Cancer Chemoprevention
Yurista Gilang Ikhtiarsyah
Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Antiproliferative Activity of Ethanolic Extract of Ciplukan Herbs (Physalis angulata L.) on 7,12-Dimethylbenz[a]nthracene-Induced Rat Mammary Carcinogenesis Putri, Laras Widawaty; Ikhtiarsyah, Yurista Gilang; Meiyanto, Edy; Monikawati, Ameilinda; Farida, Sofa
Indonesian Journal of Cancer Chemoprevention Vol 2, No 2 (2011)
Publisher : Indonesian Research Gateway

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Abstract

Physalis angulata  L.  is  an  annual  herb  widely  used  as  popular  medicine  for  the treatment of cancer. Physalis angulata L. ethanolic extract (PEE) has been demonstrated to have strong cytotoxic activity against breast cancer, inhibited cancer cell’s proliferation and induced  cell  cycle  arrest.  The  aim  of  our  study  is  to  investigate  the  effect  of  PEE  as  a cancer  chemopreventive  agent  on  7,12-dimethylbenz[a]nthracene  (DMBA)-induced  rats mammary. The antiproliferative activity was characterized by monitoring the histopatology representation  and  expression  of  cell  proliferation  on  DMBA-induced  mammary  rats  that were  treated  with  PEE  against  control  groups.  The  histopatology  representation  were analyzed  by  Haematoksilin  Eosin  (HE)  staining  method,  while  proliferative  activity  was detected by AgNOR method. The HE staining results showed significant differences in cells morphology  of  treatment  groups  compared  to  the  control  groups.  Thus  results  suggest that  PEE  was  able  to  repair  morphology  of  cells  undergoing  carcinogenesis.  AgNOR method  showed  decreasing  occurrence  of  black  dots  between  treatment  and  control groups. Thus, we conclude that PEE has an antiproliferative activity on DMBA-induced rat mammary.  Therefore,  the  ethanolic  extract  of  Physalis  angulata  herbs  is  a  potential chemopreventive agent on cancer. Further study on its molecular mechanism needs to be explored. Keywords:  Physalis  angulata,  breast  cancer, 7,12-dimethylbenz[a]nthracene, carcinogenesis, antiproliferative
Co-Authors Ameilinda Monikawati Edy Meiyanto Laras Widawaty Putri Sofa Farida