Article Per Year (5 Year)
p-Index From 2019 - 2024
0.659
P-Index
This Author published in this journals
All Journal MPI (Media Pharmaceutica Indonesiana) ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry Makara Journal of Science
Gunawan Indrayanto
Graduate Program, Faculty Of Pharmacy, University Of Surabaya, Surabaya
Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

Published : 7 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 7 Documents
Search

 1 
Simultaneous HPLC Determination of Lidocaine Hydrochloride and Hexachlorophene in a Suppository Product Cece Furwanti; Kusuma Hendrajaya; Gunawan Indrayanto
MPI (Media Pharmaceutica Indonesiana) Vol. 3 No. 1 (2020): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v3i1.2455

Abstract

Antihemoroid® suppository has been produced commercially by PT. Kimia Farma, Indonesia. For QC purposes, a separated densitometric method for analysis of its active ingredients, lidocaine hydrochloride and hexachlorophene, was applied. The objective of this study was obtaining more efficient analysis method of LH and HC, therefore an HPLC procedure has been developed for the determination of both compounds simultaneously. AYMC-Triart C18 column was used with a gradient mobile phase consisting of acetonitrile and phosphate buffer 0.05 M (pH 6.0). Quantitative evaluation was performed at 220 nm. Method validation was performed according to the new methods of USP 41. Result showed that the HPLC method was simple, accurate, precise, and robust. The HPLC method can be applied in simultaneous determination of LH and HC in suppositories as a QC tool in the pharmaceutical industries.
NON PHENOLIC COMPOUNDS ISOLATED FROM THE LEAVES OF FERN Chingia sakayensis (Zeiller) Holtt Suyatno Suyatno; Noor Cholies Zaini; Gunawan Indrayanto; Motoo Tori
Indonesian Journal of Chemistry Vol 6, No 1 (2006)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (171.909 KB) | DOI: 10.22146/ijc.21779

Abstract

Two non phenolic compounds namely a wax ester hexacosyl hexadecanoic and   a steroid -sitosterol were isolated from the n-hexane extract of the fern Chingia sakayensis (Zeiller) Holtt's leaves. Their structures were elucidated on the basis of the spectrometric evidences  (UV, IR, 1H-NMR, 13C-NMR, EIMS and HR-CIMS).
Sterol and Triterpene Profiles of the Callus Culture of Solanum mammosum Juliana, Silvy; Suciati,; Indrayanto, Gunawan
Makara Journal of Science Vol. 23, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study aimed to compare the sterol and triterpene profiles of two types of Solanum mammosum callus cultures , i.e., compact globular structure (CGS) and normal fine (F) calluses. The CGS callus resulted from the differentiation of the F calus culture after many years of subculturing. The growth rate, microscopic characteristics, and morphologies of the two callus types were determined and compared. Sterols and triterpenes were identified through thin-layer chromatog-raphy, gas chromatography-flame ionization detection, and gas chromatography–mass spectrometry analyses. The growth rate of the CGS callus was lower than that of the F callus. Microscopic identification revealed that thick, lignincontaining cell walls formed in the CGS callus but not in the F callus. The chromatographic analysis suggested that the CGS and F callus cultures had different sterol and triterpenoid profiles. The sterols and triterpenes produced by the CGC culture were more diverse than those produced by the F callus culture
Identification of Massoia Lactone and its Hydroxy-derivative from Kabatiella caulivora, an Endophyte of the Terrestrial Plant Alyxia reinwardtii Laili, Izzatul; Gunarso, Sri; Wathan, Nashrul; Sugijanto, Noor Erma; Indrayanto, Gunawan
Makara Journal of Science Vol. 21, No. 4
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Massoia lactone (1) and its derivative, 3,5-dihydroxydecanoic acid-d-lactone (2), were identified from an ethyl acetate extract of the endophytic fungus Kabatiella caulivora, isolated from its host Alyxia reinwardtii. The compounds were identified by GC-MS. To the best of our knowledge, this is the first report of the identification of massoia lactone and its derivative from the endophytic K. caulivora fungus.
Identification of 4-4’-(1-methylethylidene)-bisphenol from an Endophytic Fungus Cladosporium oxysporum derived from Aglaia odorata Armila Fatma Setyaningrum; Risma Pratiwi; Suciati Suciati; Noor Erma Nasution Sugijanto; Gunawan Indrayanto
ALCHEMY Jurnal Penelitian Kimia Vol 14, No 2 (2018): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.14.2.12974.193-201

Abstract

Endophytic fungi has an economic potential as raw material for biologically active compounds. Cladosporium oxysporum is one of the endophytic fungi isolated from Indonesian medicinal plant Aglaia odorata Lour (Local name: Pacarcina). This planth has been used for fever, cough, diarrhea, inflammation and injury. In our previous study, the ethyl acetate extract and several fractions of the extract of C. oxysporum showed antimicrobial activity against Candida albicans, Escherichia coli, and Staphylococcus aureus. The objective of the currents study is to investigate the chemical constituent of the active fraction. Purification of the metabolite was achieved by using column chromatography followed by preparative thin layer chromatography. Identification of the metabolite was conducted by using TLC densitometry, GC-FID and GC-MS. Compound 1 was isolated from fraction 12. The purity of this compound was determined by 2D-TLC and GC-FID. The UV-Vis profile of compound 1 indicates a phenolic compound. Further analysis by using GC-MS shows one peak at a retention time (Rt) of 23.80 minutes, predicted as 4-4’-(1-methylethylidene)-bisphenol. The chemical constituent of the sub fraction 12.2.7 (fraction a) is identified as 4-4’-(1-methylethylidene)-bisphenol.
Application of Accuracy and Precision Evaluations Based on the Current United States and Indonesian Pharmacopoeias: A Critical Review Indrayanto, Gunawan
Makara Journal of Science Vol. 26, No. 4
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

New methods for the evaluation of accuracy and precision are mentioned in the latest edition of the United States Pharmacopoeia (USP), whereas other validation parameters, that is, selectivity, linearity, range, and robustness, remained relatively unchanged. In obtaining reliable data from any chemical/pharmaceutical analysis, the analytical procedure must be validated or verified in accordance with the latest edition of the pharmacopoeia. Some review articles on the general validation methods have been published by the author. This present review will focus on the implementation and discussion of the accuracy and precision evaluation based on the current USP and Indonesian pharmacopoeia. Some examples of the calculation of several accuracy and precision method of determinations are also discussed.
Isolation of Pandangolide 1 from Cladosporium oxysporum, An Endophyte of the Terrestrial Plant Alyxia reinwardtii Hartanti, Dwi; Purwanti, Diah Intan; Putro, Herdayanto Sulistyo; Rateb, Mostafa Ezzat; Wongso, Suwidji; Sugijanto, Noor Erma; Ebel, Rainer; Indrayanto, Gunawan
Makara Journal of Science Vol. 18, No. 4
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

that the 2011 IOD was a weak and short-lived event. It developed in July, peaked in September, decayed in October and
Co-Authors Armila Fatma Setyaningrum Cece Furwanti Dwi Hartanti Ebel, Rainer Gunarso, Sri Juliana, Silvy Kusuma Hendrajaya Laili, Izzatul Motoo Tori Nashrul Wathan Noor Cholies Zaini Noor Erma Nasution Sugijanto Noor Erma Sugijanto Purwanti, Diah Intan Putro, Herdayanto Sulistyo Rateb, Mostafa Ezzat Risma Pratiwi Suciati Suciati SUCIATI, Suyatno Suyatno Wongso, Suwidji