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All Journal MPI (Media Pharmaceutica Indonesiana) ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry Makara Journal of Science
Gunawan Indrayanto
Graduate Program, Faculty Of Pharmacy, University Of Surabaya, Surabaya
Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Journal : MPI (Media Pharmaceutica Indonesiana)

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Simultaneous HPLC Determination of Lidocaine Hydrochloride and Hexachlorophene in a Suppository Product Cece Furwanti; Kusuma Hendrajaya; Gunawan Indrayanto
MPI (Media Pharmaceutica Indonesiana) Vol. 3 No. 1 (2020): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v3i1.2455

Abstract

Antihemoroid® suppository has been produced commercially by PT. Kimia Farma, Indonesia. For QC purposes, a separated densitometric method for analysis of its active ingredients, lidocaine hydrochloride and hexachlorophene, was applied. The objective of this study was obtaining more efficient analysis method of LH and HC, therefore an HPLC procedure has been developed for the determination of both compounds simultaneously. AYMC-Triart C18 column was used with a gradient mobile phase consisting of acetonitrile and phosphate buffer 0.05 M (pH 6.0). Quantitative evaluation was performed at 220 nm. Method validation was performed according to the new methods of USP 41. Result showed that the HPLC method was simple, accurate, precise, and robust. The HPLC method can be applied in simultaneous determination of LH and HC in suppositories as a QC tool in the pharmaceutical industries.
Co-Authors Armila Fatma Setyaningrum Cece Furwanti Dwi Hartanti Ebel, Rainer Gunarso, Sri Juliana, Silvy Kusuma Hendrajaya Laili, Izzatul Motoo Tori Nashrul Wathan Noor Cholies Zaini Noor Erma Nasution Sugijanto Noor Erma Sugijanto Purwanti, Diah Intan Putro, Herdayanto Sulistyo Rateb, Mostafa Ezzat Risma Pratiwi Suciati Suciati SUCIATI, Suyatno Suyatno Wongso, Suwidji