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Rochman Mujayanto
Fakultas Kedokteran Gigi, Unissula
Health Professions Medicine & Pharmacology

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EKSTRAK DAUN SALAM DALAM MENINGKATKAN EKSPRESI FIBROBLAST GROWTH FACTOR PADA ULKUS TRAUMATIK RONGGA MULUT Amrina Rosada; Rochman Mujayanto; Adisty Restu Poetri
ODONTO : Dental Journal Vol 7, No 2 (2020): December 2020
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.7.2.90-96

Abstract

Background: Traumatic ulcers are lesions of the oral mucosa caused by mechanical, chemical, and temperature trauma. Traumatic ulcer treatment aims to reduce inflammation, accelerate the healing process, and reduce pain. Bay leaf has anti-inflammatory pharmacological activities. This study aims to determine the effect of bay leaf extract on the expression of fibroblast growth factor in traumatic ulcer oral mucosa in Wistar rats.Method: This is an experimental research with a post-test only control group design, consisting of four groups with 20 sample of male Wistar rats. All animals were injured using a hot burnisher attached to the labial mucosa for 1 second. The gel was applied twice daily until the 3rd and 5th day after the ulcer has formed. Rat mucosal tissues were analyzed by immunohistochemical staining for FGF expressions. Statistical analysis using SPSS Mann-Whitney test.Result: The results showed the mean of cells expressing FGF in the bay gel extract group on the 3rd and 5th days were 8.4 ± 0.8, and 13.6 ± 0.5. Mann Whitney test results showed P<0.05 there is a significant differential expression of FGF traumatic ulcer oral mucosa of experimental animals on days 3 and 5 compared control group.Conclusion: Bay leaf extract increased FGF expression on days 3 and 5
BAY LEAF (SYZYGIUM POLYANTHUM) EXTRACT GEL EFFECT ON TNF- Α EXPRESSION IN TRAUMATIC ULCERS HEALING PROCESS Annisha Savira; Rochman Mujayanto; Musri Amurwaningsih
ODONTO : Dental Journal Vol 7, No 1 (2020): July 2020
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.7.1.25-30

Abstract

Background: Traumatic ulcers were injuries that occur to the epithelium and basement membrane, due to physical, mechanical, or chemical trauma. The healing process of traumatic ulcers was divided into three main phases, namely inflammatory, proliferation, and maturation phase. TNF-α as a proinflammatory mediator worked 2-3 days which later would be replaced by an anti-inflammatory mediator. This research aimed to determine the impact of bay leaf extract gel, which had a very high anti-inflammatory content, on TNF-α expression in accelerating the ulcers healing process.Method: This research method was an in vivo experimental laboratory research using a post-test only control design. The sample consists of 20 rats divided into four groups, namely, the control group on day 1, control groups on day 3, treatment groups on 1st day, and treatment groups on 3rd day. Rats were made traumatic ulcers on the lower lip mucosa and were given bay leaf extract gel in the morning and evening. The tissue was then made into a histological preparation and given immunohistochemical staining to see TNF-α.Result: The results showed the mean of cells expressing TNF-α in the bay leaf gel extract group on the 1st and 3rd days has P> 0.05. Independent T-test on 1st day dan 3rd group showed a significant difference in TNF-α expression in the control and treatment groups.Conclusion: The conclusion obtained in this study was bay leaf extract gel had a significant effect on the expression of TNF-α in the traumatic ulcers healing process.
EKSTRAK DAUN SALAM DALAM MENINGKATKAN EKSPRESI FIBROBLAST GROWTH FACTOR PADA ULKUS TRAUMATIK RONGGA MULUT Amrina Rosada; Rochman Mujayanto; Adisty Restu Poetri
Odonto : Dental Journal Vol 7, No 2 (2020): December 2020
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (325.866 KB) | DOI: 10.30659/odj.7.2.90-96

Abstract

Background: Traumatic ulcers are lesions of the oral mucosa caused by mechanical, chemical, and temperature trauma. Traumatic ulcer treatment aims to reduce inflammation, accelerate the healing process, and reduce pain. Bay leaf has anti-inflammatory pharmacological activities. This study aims to determine the effect of bay leaf extract on the expression of fibroblast growth factor in traumatic ulcer oral mucosa in Wistar rats.Method: This is an experimental research with a post-test only control group design, consisting of four groups with 20 sample of male Wistar rats. All animals were injured using a hot burnisher attached to the labial mucosa for 1 second. The gel was applied twice daily until the 3rd and 5th day after the ulcer has formed. Rat mucosal tissues were analyzed by immunohistochemical staining for FGF expressions. Statistical analysis using SPSS Mann-Whitney test.Result: The results showed the mean of cells expressing FGF in the bay gel extract group on the 3rd and 5th days were 8.4 ± 0.8, and 13.6 ± 0.5. Mann Whitney test results showed P<0.05 there is a significant differential expression of FGF traumatic ulcer oral mucosa of experimental animals on days 3 and 5 compared control group.Conclusion: Bay leaf extract increased FGF expression on days 3 and 5
BAY LEAF (SYZYGIUM POLYANTHUM) EXTRACT GEL EFFECT ON TNF- Α EXPRESSION IN TRAUMATIC ULCERS HEALING PROCESS Annisha Savira; Rochman Mujayanto; Musri Amurwaningsih
Odonto : Dental Journal Vol 7, No 1 (2020): July 2020
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (389.956 KB) | DOI: 10.30659/odj.7.1.25-30

Abstract

Background: Traumatic ulcers were injuries that occur to the epithelium and basement membrane, due to physical, mechanical, or chemical trauma. The healing process of traumatic ulcers was divided into three main phases, namely inflammatory, proliferation, and maturation phase. TNF-α as a proinflammatory mediator worked 2-3 days which later would be replaced by an anti-inflammatory mediator. This research aimed to determine the impact of bay leaf extract gel, which had a very high anti-inflammatory content, on TNF-α expression in accelerating the ulcers healing process.Method: This research method was an in vivo experimental laboratory research using a post-test only control design. The sample consists of 20 rats divided into four groups, namely, the control group on day 1, control groups on day 3, treatment groups on 1st day, and treatment groups on 3rd day. Rats were made traumatic ulcers on the lower lip mucosa and were given bay leaf extract gel in the morning and evening. The tissue was then made into a histological preparation and given immunohistochemical staining to see TNF-α.Result: The results showed the mean of cells expressing TNF-α in the bay leaf gel extract group on the 1st and 3rd days has P> 0.05. Independent T-test on 1st day dan 3rd group showed a significant difference in TNF-α expression in the control and treatment groups.Conclusion: The conclusion obtained in this study was bay leaf extract gel had a significant effect on the expression of TNF-α in the traumatic ulcers healing process.
Co-Authors Adisty Restu Poetri Amrina Rosada Annisha Savira Musri Amurwaningsih