Article Per Year (5 Year)
p-Index From 2019 - 2024
0
P-Index
This Author published in this journals
All Journal Sport and Fitness Journal
Hesty Rohmatul Fajri
Prodi S1 Pendidikan Dokter Fakultas Kedokteran, Universitas Airlangga, Surabaya
Social Sciences

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
PENGARUH PEMBERIAN GLUTATHIONE PRA LATIHAN SUBMAKSIMAL TERHADAP JUMLAH TROMBOSIT DAN MASA PERDARAHAN : STUDI EKSPERIMENTAL PADA HEWAN COBA Hesty Rohmatul Fajri; Raden Argarini; Choesnan Effendi
Sport and Fitness Journal Volume 3, No.1, 2015
Publisher : Program Studi Magister Fisiologi Keolahragaan, Fakultas Kedokteran, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (57.159 KB)

Abstract

Submaximal activity leads to oxidative stress that causes cellular damage, including platelet. Glutathione as a potential antioxidant has cellular protective effect. The purpose of this research was to analize the effect of glutathione pre submaximal exercise on platelet count and bleeding time. The study used separate post test only control group design with 28 male rats (Rattus norvegicus, Wistar strain) which were divided into four groups : P1(6) without intervention; P2(7), P3(8), and P4(7) with administration of placebo (aquabidest), glutathione 54 mg/kgBB, and glutathione 108 mg/kgBB intraperitoneally for each group that were given 5 times, continued with submaximal exercise (swimming with 4% of weight load). The result of ANOVA and LSD test showed that submaximal exercise had tendency to decrease platelet count (p=0,407; not significant) and prolonged bleeding time (p=0,017). Glutathione pre submaximal exercise had tendency to increase platelet count (p=0,407; not significant) and shortened bleeding time (p=0,017). Glutathione with a dose of 54 mg/kg had protective effect on platelet better than a dose of 108 mg/kg. In conclusion, the administration of glutathione pre submaximal exercise has protective effect on platelet in male rats (Rattus norvegicus).
Co-Authors Choesnan Effendi Raden Argarini