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All Journal METAMORFOSA Journal of Biological Sciences
Iriani Setyawati
Universitas Udayana
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Immunology & microbiology

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Morfologi dan Perkembangan Skeleton Fetus Tikus (Rattus norvegicus L.) yang Diberi Pakan Mengandung Kulit Nanas (Ananas comosus Merr.) selama Kebuntingan Ni Komang Frely Astuti; Iriani Setyawati; Inna Narayani
Metamorfosa: Journal of Biological Sciences Vol 6 No 1 (2019)
Publisher : Prodi Magister Ilmu Biologi, Fakultas MIPA, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/metamorfosa.2019.v06.i01.p20

Abstract

Pineapple peel in animal feed might contain bromelain enzyme which could distrupt pregnancy in animal laboratory. This experiment used a complete randomized design with 16 pregnant rats which were divided into four treatment groups. The treatments are feed containing 0 (K); 4,35 (P1); 8,70 (P2); and 13,05 (P3) g/rat/day of pineapple peel that were given during pregnancy. Parameters of morphological fetus observed were alive fetuses, weight, length, and fetal abnormalities and skeleton development i.e. axial skeleton (costal, sternebral, and vertebral bones) and appendicular skeleton (vertebra caudal, metacarpal and metatarsal bones). Data were analyzed by SPSS version 22, using One Way Anova or Kruskal Wallis. The result showed that fetuses from pregnant rats which administered with feed containing pineapple peel showed teratogenic effect. Fetal morphological abnormalities of the fetus is subcutaneous hemorrhage in were found at dose of 8,70 (P2) and dose of 13,05 (P3) g/rat/day. Feed containing pineapple peel could inhibit ossification of apendicular skeleton in vertebra caudal, metacarpal, and metatarsal.
Co-Authors Inna Narayani Ni Komang Frely Astuti