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All Journal Jurnal Veteriner Magister Scientiae Jurnal Performa : Jurnal Manajemen dan Start-up Bisnis
Nurul Arifah
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Decision Sciences, Operations Research & Management Education Languange, Linguistic, Communication & Media Physics Veterinary

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Kombinasi Calcitriol dan Ethynil Ethyl Estradiol Meningkatkan Ekskresi Kalsium Urin dan Risiko Urolitiasis pada Tikus Ovariektomi Hartiningsih Hartiningsih; Ayu Dewi Puspitasari; Nurdysa Diliana Putri; Nurul Arifah; Wari Pawestri; Devita Anggraeni
Jurnal Veteriner Vol 18 No 2 (2017)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (173.684 KB) | DOI: 10.19087/jveteriner.2017.18.2.239

Abstract

The high excretion of calcium (Ca) in the urine can trigger the formation of urolith. Estrogen and calcitriol decrease urinary Ca excretion. This study aims to examine the combination of calcitriol and ethinyl ethyl estradiol against Ca urinary excretion and urolithiasis risk of ovariectomized rats. Twentyfive female Wistar rats eight weeks old were divided into five groups: i) normal control (NK); ii) ovariectomized control (OVK); iii) ovariectomized + calcitriol (OVD); iv) ovariectomized + ethinyl ethyl estradiol (OVE); and v) ovariectomized + combination calcitriol and ethinyl ethyl estradiol (OVDE). Seven weeks post-ovariectomy, each rat was put in an individual metabolic cage for the study of Ca balance. At day 4 to 7 of the study, residual feed, urine, and feces were collected daily for Ca analysis. At day 8, the rats were euthanized, the left kidney were collected for histopathological examination. The results showed that combination of calcitriol and ethinyl ethyl estradiol in OVDE rats caused Ca intake and Ca intestinal absorption significantly higher, and urinary Ca excretion tended to be higher although not significantly different compared to OVK rats. Calcium excretion in OVK rat urine was higher compared to the NK rats. The kidney histopathological changes of OVK rats were not different from the NK rats. Histopathological examination of the OVDE group kidney showed protein deposition in the capsular of Bowman’s capsule and proximal tubules, atrophy of the proximal tubules, and necrosis, respectively. It is concluded that the combination of calcitriol with ethinyl ethyl estradiol in ovariectomized rats increased urinary Ca excretion and increased the risk of urolithiasis. ABSTRAK Tingginya ekskresi kalsium (Ca) dalam urin dapat menjadi pemicu terbentuknya urolit. Estrogen dan calcitriol menurunkan ekskresi Ca urin. Penelitian ini dilakukan bertujuan untuk mengkaji kombinasi calcitriol dan ethynil ethyl estradiol terhadap ekskresi Ca dalam urin dan risiko urolitiasis tikus ovariektomi. Sebanyak 25 tikus Wistar betina umur delapan minggu, dibagi menjadi lima kelompok (kontrol normal NK, kontrol ovariektomi OVK, ovariektomi + calcitriol OVD, ovariektomi + ethynil ethyl estradiol OVE, dan ovariektomi + kombinasi calcitriol dan ethynil ethyl estradiol OVDE). Tujuh minggu pascaovariektomi, setiap tikus dimasukan kandang metabolik individu untuk studi keseimbangan Ca. Pada hari ke-4 sampai 7 studi keseimbangan Ca, setiap hari sisa pakan, urin, dan feses dikumpulkan untuk analisis Ca. Pada hari ke-8 studi keseimbangan Ca, tikus dieutanasi, ginjal kiri diambil untuk pemeriksaan histopatologi. Hasil analisis menunjukkan bahwa kombinasi calcitriol dan ethynil ethyl estradiol pada tikus OVDE menyebabkan konsumsi Ca dan absorpsi Ca intestinal nyata lebih tinggi, dan ekskresi Ca dalam urin cenderung lebih tinggi meskipun tidak berbeda nyata dibanding tikus OVK. Ekskresi Ca dalam urin tikus OVK lebih tinggi dibanding tikus NK. Gambaran histopatologi ginjal OVK terlihat tidak berbeda dengan tikus NK. Histopatologi ginjal OVDE terlihat endapan protein dalam ruang kapsuler kapsula Bowman’s dan tubulus proksimalis, tubulus proksimalis atropi, dan nekrosis. Dari hasil penelitian disimpulkan bahwa kombinasi calcitriol dengan ethynil ethyl estradiol pada tikus ovariektomi meningkatkan ekskresi Ca urin dan meningkatkan risiko urolitiasis.
The Teacher’s Roles in Teaching English for Specific Purposes to Nursing Program Students Nurul Arifah; V. Luluk Prijambodo
Magister Scientiae No 36 (2014)
Publisher : Widya Mandala Surabaya Catholic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (175.569 KB) | DOI: 10.33508/mgs.v0i36.624

Abstract

The consideration of mastering English nowadays brings advanced concept in order to reach better education and career in globalization era and the mindset changes of English language education, particularly in nursing as a familiar job within public health. Related to that phenomenon, English for Specific Purposes (ESP) teacher should also notice that in teaching ESP they have to play their roles to help students in the teaching and learning process. Considering the importance of the teacher’s roles in teaching ESP, this study aimed at finding out the teacher’s roles in the teaching and learning process of ESP to nursing program students. Besides, this study also aimed at finding out the students responses towards the roles in the teaching and learning process of ESP to nursing program students. This qualitative case study focuses primarily on understanding in depth the teacher’s roles in the teaching and learning process of ESP to nursing program students. The data to cope with ‘the roles played by the teacher in the teaching of ESP’ were both verbal and nonverbal performance when the teachers were playing their roles in classroom while the data to deal with ‘the students’ response towards the teacher’s roles’ were the students’ opinion and attitude towards the teachers’ performance in the classroom. For both research questions, the data collection and analysis procedures were done using classroom observations (using audio visual recording, observation sheet, and fields note), questionnaire and interview (for both the teacher and students). This study found that the kinds of roles played by the research subjects were as the lecturer, clinical or practical teacher, role model, facilitator, mentor, assessor, curriculum assessor, resource developer, and study guide producer. This study also found that the students’ responses towards the teacher’s roles were that they liked when the teacher could do their roles well in the class. The students could also be able to understand their response towards the teacher’s roles that would have impact to their learning process, thus they became active and enthusiastic. While each of the nine of the eleven roles played has been described separately, in reality they are often interconnected and closely related one to another. The teacher’s roles in the teaching and learning process of ESP to nursing program students could be used by teachers as
PENGARUH IKLAN ONLINE DAN DESAIN PRODUK TERHADAP MINAT BELI KONSUMEN CV. QUMI LABEL Nurul Arifah
Jurnal Performa : Jurnal Manajemen dan Start-up Bisnis Vol. 5 No. 6 (2020): Performa
Publisher : Universitas Ciputra Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37715/jp.v5i6.1853

Abstract

Penelitian yang berjudul “Pengaruh Iklan Online dan Desain Produk Terhadap Minat Beli Konsumen CV. Qumi Label” ini memiliki dua tujuan, yaitu: (1) Mengetahui pengaruh iklan online terhadap minat beli konsumen CV. Qumi Label (2) Mengetahui pengaruh desain produk terhadap minat beli konsumen CV. Qumi Label. CV. Qumi Label merupakan perusahaan manufaktur jilbab yang terletak di Kota Malang. Penjualan yang dilakukan oleh CV. Qumi Label yaitu secara online tanpa ada gerai offline. Penelitian ini menggunakan metode kuantitatif. Populasi dalam penelitian ini yaitu seluruh calon konsumen CV. Qumi Label di Kabupaten Gresik. Sampel pada penelitian ini yaitu 400 responden. Pengumpulan data menggunakan kuesioner yang disebarkan secara online. Pengolahan data dalam penelitian ini menggunakan analisis regresi linier berganda dengan menggunakan SPSS sebagai alat bantu dalam mengolah data. Hasil dari penelitian ini adalah: (1) Iklan online berpengaruh positif dan signifikan terhadap minat beli konsumen CV. Qumi Label dengan nilai signifikansi < 0,05 yaitu sebesar 0,000, maka diterima (2) Desain produk berpengaruh positif dan signifikan terhadap minat beli konsumen CV. Qumi Label dengan nilai signifikansi < 0,05 yaitu sebesar 0,000, maka diterima. Kata Kunci: Iklan Online, Desain Produk, Minat Beli.
Co-Authors Ayu Dewi Puspitasari Devita Anggraeni Hartiningsih Hartiningsih Nurdysa Diliana Putri V. Luluk Prijambodo Wari Pawestri