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All Journal Pharmaciana: Jurnal Kefarmasian Pharmasipha JOPS (Journal Of Pharmacy and Science) Jurnal Kreativitas PKM Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal EduHealth Jurnal Sains dan Kesehatan

Dara Pranidya Tilarso

Prodi S1 Farmasi, STIKes Karya Putra Bangsa, Tulungagung

Author-ID : 2988308

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

Published : 11 Documents Claim Missing Document

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Uji Aktivitas Antibakteri Fraksi Batang Pepaya (Carica papaya Linn.) terhadap Bakteri Escherichia coli ATCC 25922 Secara In Vitro Mia Audina Curnia Safitri; Amalia Eka Putri; Dara Pranidya Tilarso
Jurnal Sains dan Kesehatan Vol. 2 No. 4 (2020): Jurnal Sains dan Kesehatan
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Bakteri Escherichia coli ATCC 25922 merupakan mikroorganisme patogen yang menjadi penyebab terjadinya penyakit diare, meningitis, dan infeksi lainnya. Pengobatan yang umum untuk penyakit infeksi adalah antibiotik, akan tetapi terjadi banyak resistensi terhadap antibiotik yang disebabkan oleh penggunaan yang tidak tepat. Kasus resitensi tersebut mengakibatkan diperlukannya terapi alternatif untuk agen antibakteri yang berasal dari tumbuhan-tumbuhan yang memiliki potensi tinggi sebagai agen antibakteri. Batang pepaya mempunyai potensi sebagai agen antibakteri terhadap bakteri Escherichia coli ATCC 25922 yang merupakan bakteri patogen penyebab infeksi pada manusia. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antibakteri pada fraksi batang pepaya terhadap bakteri Escherichia coli ATCC 25922 dengan menggunakan metode difusi cakram serta untuk mengetahui fraksi batang pepaya yang memiliki zona hambat paling tinggi. Metode penelitian yang digunakan yaitu metode eksperimental. Sampel penelitian adalah batang pepaya yang di ekstraksi dengan menggunakan metode maserasi dengan pelarut etanol 96%. Ekstrak kemudian difraksinasi dengan menggunakan metode partisi cair – cair menggunakan pelarut n-heksana, diklorometana, dan aquadestilata. Fraksi batang pepaya dilakukan skrining fitokimia untuk mengetahui senyawa yang terkandung didalamnya. Kontrol positif yang digunakan yaitu tablet eritromisin 500 mg dan kontrol negatif yang digunakan yaitu masing-masing pelarut fraksi. Fraksi batang pepaya masing-masing dibuat dengan konsentrasi 1%. Analisa statistik dilakukan dengan menggunakan metode uji Shapiro-Wilk, Kruskal-Wallis, serta Mann-Whitney. Hasil uji aktivitas antibakteri fraksi batang pepaya menunjukkan hasil bahwa fraksi batang pepaya mempunyai aktivitas sebagai antibakteri terhadap bakteri Escherichia coli ATCC 25922. Fraksi n-heksana, diklorometana, dan aquadestilata batang pepaya masing-masing dengan konsentrasi 1% secara berurutan mempunyai rata-rata diameter zona hambat sebesar 12,57 ± 0,23 mm, 15,33 ± 0,35 mm, dan 18,97±0,58 mm. Aktivitas antibakteri diperkirakan berasal dari aktivitas senyawa flavonoid, tanin, dan saponin yang terkandung di dalam fraksi batang pepaya.

Pengaruh Konsentrasi PVA terhadap Stabilitas dan Aktivitas Antioksidan Masker Peel Off Ekstrak Kulit Jengkol (Archidendron pauciflorum (Benth.) Nielsen) Zahrina Hanny Nabila; Ary Kristijono; Dara Pranidya Tilarso
Jurnal Sains dan Kesehatan Vol. 2 No. 4 (2020): Jurnal Sains dan Kesehatan
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Abstract Jengkol skin (Archidendron pauciflorum (Benth.) Nielsen) has antioxidant activity because it contains flavonoid compounds, saponins, and alkaloids, so jengkol skin can be used as a facial treatment. The peel off mask preparation was chosen because is one type of cosmetic that is easy to use because it utilizes the ability to release the film layer when applied to the skin so that it can increase comfort in use and is expected to increase the antioxidant activity of jengkol skin extract. Components of masks such as PVA (Polyvinyl Alcohol) which act as filming agents, affect the physical properties of the mask, because it is the material underlying the peel off mask. A stability test needs to be carried out to ensure the durability of the mask during storage. This study aims to determine the stability and antioxidant activity of peel off masks of jengkol skin from various concentrations of PVA. The method used is maceration with 70% ethanol solvent. PVA was used with concentrations of 6%, 8% and 10%. The physical properties test includes organoleptic test, pH test, homogenity test, adhesion test, dispersion test, dry time test, and viscosity test. The antioxidant test of peel off mask preparations was carried out by DPPH method (1,1 Difenyl-2-picrylhydrazil). Based on the results of the study, it was obtained that the peel off mask preparation was stable for a maximum of 21 days of storage. Formula with a PVA concentration of 10% is the formula that has the best physical properties during storage but is the most unstable formula because there are more white lumps than other formulas on the 28th day. The IC50 values ??were 420.9 ?g/mL, 397.4 ?g/mL and 434.1 ?g/mL

Aktivitas Anti Candida albicans ATCC 14053 Sediaan Pasta Gigi Gel Ekstrak Daun Jengkol (Archidendron pauciflorum) dengan Kombinasi Na-CMC dan Karbomer: Activity of Anti-Candida albicans ATCC 14053 Toothpaste Gel Leaf Extract Jengkol (Archidendron pauciflorum) with Combination of Na-CMC and Carbomer Aria Agustina Achsia; Ary Kristijono; Dara Pranidya Tilarso
Jurnal Sains dan Kesehatan Vol. 3 No. 2 (2021): Jurnal Sains dan Kesehatan
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Jengkol leaf extract can inhibit the growth of the fungus Candida albicans because it contains flavonoids, saponins, and tannins. Candida albicans species are most commonly found in the oral cavity that can cause various diseases in humans as canker sores and skin lesions. The purpose of this study was to formulate jengkol leaf extract into gel toothpaste preparations by distinguishing variations in the concentration of carbomer as a gelling agent. The research method used is experimental. Jengkol leaf samples extracted using the maceration method with 70% ethanol. The concentration of active substance used in each formula was 7.5% based on the preliminary test results and the carbomer concentration used was 0.5% in formula I, 1% in formula II, 1.5% in formula III, and 2% in formula IV. The physical stability test consists of organoleptic, homogeneity, spreadability, viscosity, pH, and high foam for 28 days of storage. Antifungal activity test using the disc diffusion method. Statistic analysis performed using the Shapiro-Wilk, Levene Statistics, and One Way Anova methods. During 28 days of keeping all formula homogeneous stable. The viscosity increased in each formulation due to differences in the concentration of carbomer used, the higher of carbomer the more viscous of the preparation, the pH, foam height of the formulation was stable and met the standard. The particles are evenly distributed so that the formulation colors and odors have stable. The result of the antifungal activity test of toothpaste gel extract of 7,5% jengkol leaf has inhibition of 11 mm. The increase in carbomer concentration showed a significant difference in each formula based on the One Way Anova statistical analysis (p <0.05) and the addition of carbomers to the formula showed stable viscosity and high foam. The most stable formula is the formula I with a carbomer concentration of 0.5%.

Co-Authors Afidatul Muadifah Amalia Putri Eka Aria Agustina Achsia Ary Kristijono Ary Kristijono Choirul Huda Choirul Huda Erlisa Maratul ‘Alimah Febry Irvanda Kartika Arum Wardani Mia Audina Curnia Safitri Moch. Saiful Bachri Muhammad Ary F Nurul Hidayah Ratih Salimil Ummah Siti Anisa Ningrum Siti Anisaningrum Ulfi Helmiana Dewi Wahyu Widyaningsih Zahrina Hanny Nabila

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