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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Farmasetis Acta Holistica Pharmaciana
Made Dwi Pradipta Wahyudi S
Sekolah Tinggi Farmasi Mahaganesha
Chemical Engineering, Chemistry & Bioengineering Chemistry Education Medicine & Pharmacology Public Health Other

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Development and optimization of Curcuma longa Linn. oleoresin non-aqueous gel for transdermal delivery Dewa Ayu Arimurni; Made Dwi Pradipta Wahyudi S; Erika Yuda Colatama
Pharmaciana Vol 12, No 1 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (646.828 KB) | DOI: 10.12928/pharmaciana.v12i1.22285

Abstract

A long-term oral administration of NSAID and DMARD on rheumatoid arthritis (RA) treatment may cause gastritis, kidney, and cardiovascular disorder. One of the alternative therapies that have been investigated is by using herbal medicine such as Curcuma longa Linn. which contains curcumin and essential oils. Even though both compounds are quite effective in treating RA, poor aqueous solubility and low intestinal absorption limit their oral bioavailability. To overcome these drawbacks, transdermal delivery was chosen as an alternative route of administration. This study was aimed to formulate the Curcuma longa Linn. oleoresin into a transdermal non-aqueous gel system using Carbopol 934 and low substituted hydroxypropyl cellulose (4.25:0.75 %) as the gelling agent. In this study, multiple solvents (PEG 400, PG, glycerin, ethanol, and tween 20) were used in the system. The solvents were chosen based on their ability to dissolve the gelling agents. Optimization was done using a simplex lattice design based on the physical characteristics (viscosity, pH, spreadability, and adhesivity) of the prepared gel. The system with the optimum concentration of PEG 400 and PG was then observed for its stability and in vitro transport through snakeskin membrane using Franz diffusion cell with PBS pH 7.4 as acceptor medium. The optimal formula was comprised of 75% PEG and 25% PG which has a viscosity of 6.34+0.19 dPa.s, adhesivity of 6.05+0.11 seconds, pH of 5.16+0.09, spreadability of 6.94+0.06 cm, and quite stable after freeze-thaw cycling test, whilst around 26.85% curcumin was diffused through the membrane (flux = 0.084 mg.cm-2) after 2 hours. It can be concluded that the Curcuma longa Linn. oleoresin can be formulated into a non-aqueous gel system, which showed a fair gel physical characteristic with good stability and ability to permeate across the skin membrane, and is promising to be further developed as an alternative for RA treatment.
Formulation optimization and wound healing activity of Vitex trifolia L leaf extract loaded chitosan hydrogel film on hyperglycemic rats Made Dwi Pradipta Wahyudi S; Dewa Ayu Arimurni; Komang Angelita Safira; Erika Yuda Colatama; Putu Bisma Duta Valenrika
Pharmaciana Vol 12, No 3 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (617.307 KB) | DOI: 10.12928/pharmaciana.v12i3.25035

Abstract

Decreased blood supply, high blood sugar level, and a possibility of bacterial infection in diabetic wounds pose risk for limb loss and mortality. Therefore, proper wound care is needed to improve the quality of life of diabetic patients. Vitex trifolia L (Legundi) extract is reported to have antibacterial and antioxidant activity that enhances cell proliferation and migration. The antimicrobial and hemostatic properties of chitosan film are viewed as an ideal material for enhancing wound healing. The film should retain its integrity and flexibility while used on the skin, therefore chitosan was combined with PVA and PVP K30 to improve its quality. The objectives of this study were to optimize the concentration of chitosan, PVP K30, and PVA towards the Legundi extract film properties, and to evaluate its wound healing activity on hyperglycemic mice using an incision wound model. In this study, the film’s compositions were optimized using a simplex lattice design, and the effects of its components on their characteristics, such as thickness, weight, folding endurance, swelling rate, and swelling index, were evaluated. BALB/c Mice were divided into three groups (Group I, Group II, Group III) which were treated with normal saline, placebo film, and Legundi film respectively once daily for 8 days. The result suggested that chitosan and PVA were responsible for affecting the film’s thickness, weight, and folding endurance, whilst PVP K30 was the dominant factor in increasing the swelling index and rate of the film. The optimum formula of Legundi extract films consists of 1.15 %(b/v) chitosan, 1.25 %(b/v) PVP K30, and 1.6 %(b/v) PVA. The animal treated with Legundi extract film have higher wound closure compared to the control and placebo group four days after wound incision (p<0.05). Thus, Legundi extract film was a potential dressing to treat a diabetic wound.
Optimasi Komposisispan 60 dan Tween 80 dalam Sediaan Body Cream Ekstrak Umbi Bit Menggunakan Metode Simplex Lattice Design Made Dwi Wahyudi S.; Ni Komang Eni Astari; Ni Putu Ratna Mulia Adnyani; Dewa Ayu Arimurni; Elisabeth Oriana Jawa la
Jurnal Farmasetis Vol 12 No 4 (2023): Jurnal Farmasetis: November 2023
Publisher : LPPM Sekolah Tinggi Ilmu Kesehatan Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32583/far.v12i4.1405

Abstract

Umbi bit (Beta vulgaris), salah satu tanaman yang banyak tumbuh di Indonesia, diketahui memiliki aktivitas antioksidan. Penelitian ini bertujuan untuk mengoptimasi komposisi span 60 dan dan tween 80 pada krim ekstrak etanol umbi bit. Optimasi konsentrasi span 60 serta tween 80 dilakukan dengan metode Simplex Lattice Design menggunakan Design Expert 13.0. Sediaan yang dibuat dievaluasi karakteristiknya yang meliputi organoleptis, homogenitas, daya sebar, pH, dan daya lekat. Hasil penelitian menunjukkan bahwa perbedaan komposisi span 60 dan tween 80 dapat mempengaruhi kualitas fisik sediaan body cream ekstrak umbi bit yang meliputi daya sebar, daya lekat dan pH. Formula optimum krim ekstrak etanol umbi bit diketahui memiliki komposisi 2,34% span 60 dan 2,86% Tween 80 dengan diameter sebar sebesar 5,31 cm; pH 7,05; daya lekat 0,48 s dan viskositas 96,67 dPa.s.
PENDEKATAN SIMPLEX LATTICE DESIGN PADA FORMULASI WOUND DRESSING GEL PENTOXIFYLLINE DENGAN KOMBINASI GELLING AGENT HPMC DAN CHITOSAN Dewa ayu Arimurni; Made Dwi Pradipta Wahyudi S; Gede Ngurah Ary Zega Widyartha; Luh Gede Tina Sujayanti; Gracia Isabel Baptista Soares
Acta Holistica Pharmaciana Vol 2 No 2 (2020): Acta Holistica Pharmaciana
Publisher : School of Pharmacy Mahaganesha (Sekolah Tinggi Farmasi Mahaganesha)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pentoxifylline terbukti memiliki khasiat sebagai penyembuh luka seperti ulkus diabetik. Pentoxifylline pada penelitian inidiformulasikan dalam bentuk sediaan gel dengan kombinasi basis HPMC dan Chitosan. Penggunaan kombinasi ini diketahui akan menghasilkan gel dengan sifat fisik yang lebih baik daripada penggunaan tunggal. Penelitian ini bertujuan untuk meneliti pengaruh variasi HPMC dan chitosan terhadap sifat fisik gel dan stabilitas fisik gel pentoxifylline selama penyimpanan, serta mencari konsentrasi HPMC dan Chitosan yang optimum. Sediaan gel dibuat dengan konsentrasi pentoxifylline sebesar 1% dengan basis HPMC dan chitosan. Komposisi HPMC dan chitosan ditentukan melalui proses skrining dan dioptimasi menggunakan metode Simplex Lattice Design dengan perangkat lunak Design Expert trial version 10.0.3. Masing-masing formula diuji sifat fisiknya yang meliputi pH, viskositas, daya sebar, dan daya lekat. Formula optimum gel pentoxifylline terdiri dari 3,5% HPMC dan 1,5% chitosan. Hasil uji sifat fisik gel pentoxifylline optimum menunjukkan bahwa sediaan yang diperoleh homogen dengan nilai pH 5, viskositas 266,67 dPa.S, daya sebar 43,33 cm.g/menit, dan daya lekat 2,16 detik. Gel pentoxifylline stabil selama 7 siklus pengujian meliputi daya lekat, viskositas, daya sebar dan daya lekat, gel stabil ditandai dengan P value tidak berbeda signifikan.
Co-Authors Dewa Ayu Arimurni Elisabeth Oriana Jawa La Erika Yuda Colatama Gede Ngurah Ary Zega Widyartha Gracia Isabel Baptista Soares Komang Angelita Safira Luh Gede Tina Sujayanti Ni Komang Eni Astari Ni Putu Ratna Mulia Adnyani Putu Bisma Duta Valenrika