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All Journal Jurnal Surya Medika Health Sciences and Pharmacy Journal Lombok Journal of Science Jurnal Sains dan Kesehatan Jurnal Farmasetis Indonesian Journal of Pharmacy and Natural Product Prosiding SIMKESNAS Borneo Journal of Pharmacy
Elisabeth Oriana Jawa La
Sekolah Tinggi Farmasi Mahaganesha
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Uji Aktivitas Antioksidan Body Butter Ekstrak Etanol Kulit Buah Naga Merah dengan Metode DPPH Repining Tiyas Sawiji; Elisabeth Oriana Jawa La
Jurnal Surya Medika (JSM) Vol 6 No 2 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v6i2.2096

Abstract

Red dragon fruit peels (Hylocereus polyrhizus) are considered important by the community. While the red dragon fruit peel contains flavonoids, betacyanin, anthocyanin, and vitamin C which have antioxidant activity so that it can ward off free radiation and prevent cell damage. Antioxidants are molecules that can prevent the oxidation of other molecules. Antioxidants can protect the skin from various free radical cell damage. The body butter is a pharmaceutical preparation in the cosmetic field that can be used for skin health care. This study aims to determine the percentage of antioxidant activity and IC50 values in the body butter ethanol extract of red dragon fruit peels. Red dragon fruit peels were extracted first using the maceration method with 96% ethanol solvent. The antioxidant activity test was measured using UV-Vis spectrophotometry. The results showed that the antioxidant activity value of formula I obtained IC50 values (56.17 μg / mL), formula II IC50 values (88.26 μg / mL), and formula III IC50 values (146.05 μg / mL). From the results obtained, the body butter formula which has the greatest activity is the formula I (AAI = 0.7). Antioxidant activity in body butter preparations is included in the group of moderate antioxidants.
Identifikasi Kandungan Metabolit Sekunder dan Uji Aktivitas Antioksidan Ekstrak n-Heksana Kulit Jeruk Bali (Citrus maxima Merr.). Elisabeth Oriana Jawa La; Repining Tiyas Sawiji; Ni Made Rai Yuliani
Jurnal Surya Medika (JSM) Vol 6 No 2 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v6i2.2136

Abstract

Degenerative diseases triggered by antioxidants in the body are unable to neutralize the increased concentration of free radicals that can cause cell damage, so to destroy free radicals it is necessary to have antioxidants from outside the body. Grapefruit peel (Citrus Maxima Merr) is one plant that is known to have a lot of secondary metabolite content however it is not fully utilized. To analyze the content of chemical compounds and the antioxidant effect of n-hexane extract of Grapefruit peel (Citrus Maxima Merr.). Identification of chemical compounds was carried out by phytochemical screening and confirmed by the analysis of the extract thin layer chromatography profile, whereas the antioxidant activity test was carried out using the radical capture method of 2,2-diphenyl-1-picrylhydrazyl (DPPH) with Trolox as a comparison. The results of the identification of Grapefruit peel (Citrus Maxima Merr) extracts is containing secondary metabolites in the form of flavonoids, saponins, alkaloids, triterpenoids/steroids, and tannins. The results of antioxidant activity test extracts of grapefruit peel(Citrus Maxima Merr) and Trolox each showed values that: IC50 111.69 ppm and 12.143 ppm. From the results of this test, the extract of grapefruit peel (Citrus Maxima Merr) has moderate antioxidant activity when compared to Trolox.
Pengaruh Variasi CMC-Na Terhadap Sifat Fisik dan Stabilitas Sediaan Gel Aroma Terapi Kulit Buah Jeruk Limau (Citrus amblycarpa (Hassk.) Ochse) Repining Tiyas Sawiji; Elisabeth Oriana Jawa La; Ni Ketut Sukarmini
LOMBOK JOURNAL OF SCIENCE Vol 2 No 2 (2020): Lombok Journal of Science
Publisher : LOMBOK JOURNAL OF SCIENCE

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Abstract

Aroma menthol dan camphora dalam minyak aromaterapi yang cenderung kurang menyenangkan dan tidak bertahan lamanya minyak di kulit, membuat menthol dan camphora pada penelitian ini diformulasikan menjadi sediaan gel aromaterapi dengan memanfaatkan minyak kulit jeruk limau untuk memperbaiki aromanya. Besarnya konsentrasi gelling agent pada suatu sediaan gel sangat mempengaruhi karakteristik fisik dan stabilitas gel. Oleh karena itu, pada penelitian ini dilakukan proses optimasi konsentrasi CMC-Na (gelling agent) pada sediaan gel aromaterapi, sehingga bisa dihasilkan sediaan gel aromaterapi dengan karakteristik fisik dan stabilitas yang baik. Gel aromaterapi dibuat dalam tiga formula dengan tiga konsentrasi CMC-Na yaitu, FI 0,6%, FII 0,9%, dan FIII 1,2%. Sediaan yang sudah terbentuk kemudian diuji kualitasnya (organoleptis, homogenitas, pH, uji daya sebar, dan daya lekat) serta stabilitasnya. Data hasil pengujian ketiga formula dibandingkan dengan persyaratan pada pustaka serta dianalisis dengan ANAVA satu jalan. Pengujian stabilitas dilakukan pada suhu ruang selama 4 minggu, yang kemudian datanya dianalisis lebih lanjut dengan ANOVA satu jalan untuk memastikan tidak adanya perbedaan mutu produk sebelum dan setelah pengujian. Hasil penelitian menunjukkan bahwa semua formula menghasilkan sediaan gel yang bening, homogen, agak kekuningan, dengan aroma khas jeruk limau. FIII merupakan formula dengan daya lekat yang paling tinggi, sedangkan FI merupakan formula dengan daya sebar yang paling tinggi. Hasil pengujian stabilitas menunjukkan bahwa sediaan gel aromaterapi mengalami perubahan karakteristik selama masa penyimpanan. Berdasarkan hasil penelitian dapat disimpulkan bahwa formula I merupakan formula yang terbaik (0,6 % CMC-Na) dengan diameter sebar sebesar 4,6 cm, daya lekat sebesar 2,13 detik, dan pH sebesar 5.
Formulasi dan uji aktivitas antibakteri sediaan gel antiseptik tangan ekstrak daun puring (Codiaeum variegatum) Repining Tiyas Sawiji; Elisabeth Oriana Jawa La
Health Sciences and Pharmacy Journal Vol 6, No 1 (2022)
Publisher : STIKes Surya Global Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (491.544 KB) | DOI: 10.32504/hspj.v6i1.465

Abstract

The high incidence of infection occurs due to a lack of public awareness in getting used to a clean and healthy life. Hands are one of the media for the spread of bacteria, so an antibacterial preparation is needed. Puring leaf (Codiaeum variegatum) is a plant that contains many components of secondary metabolites, one of which is tannin compounds. Based on previous research, it has been proven that the tannin group has antibacterial activity. The use of puring leaves directly on the hands is considered less practical so it needs to be formulated in the form of hand antiseptic gel preparations. This study aims to design a hand antiseptic gel formula with variations in the concentration of puring leaf extract and to determine the antibacterial activity of hand antiseptic gel preparations from puring leaf extract against Staphylococcus aureus bacteria. This type of research was experimental laboratory. Puring leaves were first extracted using 96% ethanol as solvent and three hand antiseptic gel formulations were made with varying concentrations of extract, namely FI (1.5%), FII (4.5%), and FIII (6%) with a base gel using carbopol 940. The physical tests included organoleptic and homogeneity tests, pH tests, dispersion tests, and viscosity tests. The data obtained were analyzed using ANOVA and Kruskal Wallis. The antibacterial activity test was measured using the paper disk diffusion method. The results showed that the three formulations of hand antiseptic gel preparations puring leaf extract met the physical characteristics of good gel preparations and FIII had the highest antibacterial activity against Staphylococcus aureus with an inhibitory diameter of 3.16±0.28. Antibacterial activity in hand antiseptic gel preparation of puring leaf extract is in the weak category. Keywords: Antibacterial; puring leaf; paper disk difusi; antiseptic gel
Uji Aktivitas Antioksidan Ekstrak Etanol Daun Rosemary (Rosemarinus officinalis L.) dengan Metode DPPH dan FRAP serta Pengaplikasiannya sebagai Zat Aktif dalam Losion: Antioxidant Activity Test of Rosemary Leaves (Rosemarinus officinalis L.) Ethanolic Extract with DPPH and FRAP Method and Its Application as an Active Substance in Lotion Ni Ketut Esati; Elisabeth Oriana Jawa La; Gusti Ayu Dewi Lestari
Jurnal Sains dan Kesehatan (J. Sains Kes.) Vol. 4 No. 4 (2022): Jurnal Sains dan Kesehatan (J. Sains Kes.)
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (351.115 KB) | DOI: 10.25026/jsk.v4i4.1129

Abstract

Salah satu tanaman yang mempunyai nilai ekonomis tinggi yaitu tanaman rosemary (Rosemarinus officinalis L.).  Tanaman ini mempunyai aroma dan rasa yang khas dan banyak mengandung senyawa yang dapat dimanfaatkan sebagai antioksidan, antijamur, antivirus, antibakteri, antitumor, antitrombotik, dan antidepresan. Pemanfaatan tanaman rosemary terutama ekstrak daunnya dapat dilakukan dengan terlebih dahulu melakukan pengujian terhadap ekstrak tersebut, sehingga tujuan dari penelitian ini adalah melakukan pengujian kandungan metabolit sekunder, uji aktivitas antioksidan dengan metode DPPH dan FRAP, serta mengaplikasikannya sebagai zat aktif dalam produk lotion. Dari hasil penelitian ini didapatkan rendemen ekstrak etanol daun rosemary sebanyak 16,87%. Hasil pengujian ekstrak tersebut mengandung senyawa metabolit sekunder diantaranya alkaloid, flavonoid, tannin, dan triterpenoid, namun memberikan hasil yang negatif terhadap saponin. Uji aktivitas antioksidan dengan metode DPPH dan FRAP ekstrak menghasilkan nilai IC50 berturut-turut 10,68 ppm dan 51,84 ppm. Dengan demikian ekstrak etanol daun rosemary memiliki aktivitas antioksidan yang sangat kuat dengan pengujian metode DPPH dan aktivitas yang kuat dengan metode FRAP. Produk antioksidan sediaan topikal berupa lotion dengan zat aktif dari ekstrak etanol daun rosemary menghasilkan uji organoleptis yang baik.
Antibacterial activity extract fraction of black garlic against bacteria propionibacterium acnes with disc diffusion method Rensiana Kartini Pandi; Elisabeth Oriana Jawa La; Ni Ketut Esati
Health Sciences and Pharmacy Journal Vol 6, No 3 (2022)
Publisher : STIKes Surya Global Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32504/hspj.v6i3.732

Abstract

Black garlic is the result of processing garlic through a heating process at a temperature of 70oC with a relative humidity of 70-80% for 21 days without additional treatment so that the water content decreases. Black garlic has antibacterial activity due to the presence of bioactive compounds from the phenolic and flavonoid groups. This study aims to determine the secondary metabolite content and antibacterial activity of the black garlic extract fraction against Propionibacterium acnes bacteria. Extraction of Black garlic by maceration method used 96% ethanol as solvent and to obtain extract fraction of Black garlic by multilevel fractionation method using n-hexane, ethyl acetate, and ethanol as solvents. To determine the content of secondary metabolites, phytochemical screening was carried out in each fraction. Antibacterial activity test of Propionibacerium acnes used disc diffusion method with various concentrations of n-hexane, ethyl acetate, ethanol fractions 2%, 4%, 6%, 8%, 10%, positive control (clindamycin 1%), negative control and media control. Data analysis was carried out with qualitative, quantitative, and statistical analysis. The results obtained were the extract fraction of black garlic contains secondary metabolites of flavonoids, alkaloids, saponins, and tannins. The results of the antibacterial activity test showed that the garlic extract fraction had antibacterial activity seen from the presence of an inhibition zone. The largest inhibition zone in the n-hexane fraction of 10% concentration of 8.50 ± 0.10 mm was included in the medium category. The positive control was 12.02 ± 1.41 mm and the negative control gave no inhibition zone.
Pengaruh Formulasi Terhadap Mutu Fisik Body Butter Ekstrak Etanol Kulit Buah Naga (Hylocereus polyrhizus) Repining Tiyas Sawiji; Elisabeth Oriana Jawa La; Agustina Nila Yuliawati
Indonesian Journal of Pharmacy and Natural Product Vol. 3 No. 1 (2020)
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (473.898 KB) | DOI: 10.35473/ijpnp.v3i1.501

Abstract

Kulit buah naga memiliki beragam manfaat walaupun sering dianggap sebagai limbah. Kulit buah naga mengandung banyak pigmen warna, salah satunya antosianin yang berfungsi sebagai antioksidan. Kandungan ini mampu mencegah radikal bebas yang menyebabkan penuaan dini maupun penyakit lainnya. Antioksidan yang terdapat didalam kulit buah naga dapat dimanfaatkan sebagai zat aktif sediaan kosmetika tubuh salah satunya body butter. Salah satu faktor yang mempengaruhi stabilitas sediaan body butter adalah emulgator. Penelitian ini bertujuan untuk mengetahui pengaruh formulasi, yaitu adanya variasi konsentrasi kadar emulgator (tween 60 : span 60) terhadap stabilitas fisik body butter. Sediaan dibuat dengan 3 macam konsentrasi emulgator tween 60 : span 60 yaitu 1%, 2%, dan 3%. Ketiga formula diuji stabilitas fisiknya dengan uji organoleptis, homogenitas, pH, daya lekat, daya sebar, dan daya proteksi. Uji stabilitas fisik dilakukan pada minggu I, II, III, dan IV di suhu ruang. Data pengamatan dianalisis statistik dengan taraf kepercayaan 95%. Hasil evaluasi sediaan body butter menunjukkan bahwa variasi emulgator tidak memberikan pengaruh tehadap sifat fisik body butter meliputi organoleptis, homogenitas, pH dan daya sebar. Namun mempengaruhi uji daya lekat dan daya proteksi (p>0.05). Berdasarkan hasil pengujian, didapatkan hasil yaitu formula III lebih stabil dalam penyimpanan selama 4 minggu daripada formula I dan II.Kata kunci : ekstrak kulit buah naga, emulgator, body butter, stabilitas fisikDragon fruit peels has a variety of benefits although it is often considered a waste. Dragon fruit peels contains many color pigments, one of which is anthocyanin which functions as an antioxidant. This content is able to prevent free radicals that cause premature aging and other diseases. Antioxidants found in dragon fruit peels can be used as active ingredients for cosmetics, one of which is body butter. One of the factors that influence the stability of the body butter preparation is an emulgator. This study aims to determine the effect of the formulation, namely the variation in the concentration of emulgator levels (tween 60: span 60) on the physical stability of body butter. The preparations were made with 3 kinds of 60: span 60 emulsifier concentrations of 1%, 2%, and 3%. The three formulas were tested for physical stability by organoleptic, homogeneity, pH, adhesion, dispersion, and protection. Physical stability tests were carried out at weeks I, II, III, and IV at room temperature. Observation data were analyzed statistically with a confidence level of 95%. The results of the evaluation of body butter preparations showed that variations in the emulgator had no effect on the physical properties of the body butter including organoleptic, homogeneity, pH, and dispersion. But it affects the test of adhesion and protection (p> 0.05). Based on the test results, the results obtained are formula III is more stable in storage for 4 weeks than formulas I and II.Keywords: Hylocereus polyrhizus, emulgators, body butter, physical evaluation
Skrining Fitokimia Dan Analisis Kromatografi Lapis Tipis Ekstrak Etanol Kulit Buah Naga Merah (Hylocereus polyrhizus) Elisabeth Oriana Jawa La; Repining Tiyas Sawiji; Agustina Nila Yuliawati
Indonesian Journal of Pharmacy and Natural Product Vol. 3 No. 1 (2020)
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (558.572 KB) | DOI: 10.35473/ijpnp.v3i1.503

Abstract

Buah naga merah (Hylocereus polyrhizus) merupakan tumbuhan yang sudah banyak dimanfaatkan oleh masyarakat Indonesia secara alami sebagai tanaman kaya antioksidan, sebaliknya pemanfaatan dari kulit buah naga merah belum sepenuhnya dimaksimalkan. Beberapa penelitian yang telah dilakukan menunjukkan bahwa selain daging buah, kulit buah naga merah dapat dimanfaatkan sebagai sumber untuk pengobatan karena kaya akan antioksidan. Hal tersebut dapat digunakan sebagai dasar dan pilihan untuk menghasilkan produk obat tradisional dari kulit buah naga merah. Penelitian ini bertujuan untuk mengidentifikasi kandungan metabolit sekunder yang terdapat pada kulit buah naga merah berupa skrining fitokimia dan kromatografi lapis tipis (KLT) pada senyawa aktif yang disinyalir terkandung didalam kulit buah naga merah yang dapat dimanfaatkan dalam produk kefarmasian. Ekstraksi dilakukan dengan cara maserasi menggunakan pelarut etanol 96% diperoleh rendemen ekstrak sebanyak 2,96%. Skrining fitokimia dilakukan sebagai uji pendahuluan untuk mengidentifikasi kandungan metabolit sekunder yang terkandung dalam ekstrak kulit buah naga merah, dilanjutkan dengan KLT untuk mempertegas hasil reaksi positif. Hasil skrining dan KLT diperoleh kulit buah naga merah positif mengandung alkaloid, tanin, flavonoid, steroid dan potensial untuk dijadikan obat tradisional.Kata kunci :kulit buah naga merah, skrining fitokimia, KLT, metabolit sekunder Red dragon fruits (Hylocereus polyrhizus) generally has been widely known Indonesian as a plant that rich in antioxidant  however, the Red dragon fruits peel is not fully utilized. Some of studies have been conducted indicating that as well as its fruit flesh, Red dragon fruits peel can be beneficial as a source for treatment and traditional medicinal products since it is also rich of antioxidants.This research aims to identify the content of secondary metabolites on the Red dragon fruits peel  in the form of phytochemical screening and thin-layer chromatography (TLC) in the active compounds which can be utilized in the product of  Pharmacy. Extraction is conducted by maceration using the 96% ethanol solvent in order to produces extracts as much as 2.96 %.  Phytochemical screening is delivered as a preliminary test to identify the content of secondary metabolites contained in the peel of  Red dragon fruit peel and continued with the TLC to confirmed give positive  results. Results of  the screening and TLC obtained that the peel of  Red dragon fruits positive contains alkaloids, tannins, flavonoids, steroids and potential to be used as traditional medicineKeyword : Red dragon fruit peel, phytochemical screening, TLC, secondary metabolites 
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN PURING (Codiaeum variegatum L.) TERHADAP BAKTERI Staphylococcus aureus Elisabeth Oriana Jawa La; Putu Indra Cyntia Dewi; Ni komang yoni widyawati
PROSIDING SIMPOSIUM KESEHATAN NASIONAL Vol. 2 No. 1 (2023): Simposium Kesehatan Nasional
Publisher : LPPM STIKES BULELENG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (459.355 KB)

Abstract

Daun puring (Codiaeum variegatum L.) merupakan salah satu tanaman bunga yang banyak tumbuh di daerah Bali namun belum banyak diteliti manfaatnya. Puring memiliki aktivitas antibakteri karena kandungan matabolitnya. Penelitian ini bertujuan untuk mengetahui kandungan metabolit sekunder dan aktivitas antibakteri ekstrak etanol daun puring terhadap bakteri Staphylococcus aureus. Ekstraksi yang digunakan maserasi dan uji pendahuluan berupa skrining fitokimia. Uji aktivitas antibakteri menggunakan metode difusi paper disk dengan konsentrasi ekstrak 400µg/mL, 800µg/mL, 1600µg/mL, 3200µg/mL, 6400µg/mL, kontrol positif dan kontrol negatif. Data dihitung dengan melihat zona hambat yang terbentuk dan dianalisis statistiknya. Hasil pengujian menunjukkan ekstrak etanol daun puring mengandung metabolit sekunder alkaloid, flavonoid, saponin, tanin, steroid serta memiliki aktivitas sebagai antibakteri.
EFEK ANTIINFLAMASI EKSTRAK ETANOL 70% KULIT BUAH POMELO (Citrus maxima (Burm.) Merr) PADA TIKUS JANTAN GALUR WISTAR BERDASARKAN DOSIS PEMEJANAN Putu Dian Marani Kurnianta; Anak Agung Ngurah Putra Riana Prasetya; Elisabeth Oriana Jawa La; I Gede Krisna Yudiarta
PROSIDING SIMPOSIUM KESEHATAN NASIONAL Vol. 2 No. 1 (2023): Simposium Kesehatan Nasional
Publisher : LPPM STIKES BULELENG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (567.065 KB)

Abstract

Beberapa penelitian menunjukkan hasil positif terkait efek antiinflamasi ekstrak kulit buah pomelo pada model hewan uji, namun pengamatan efek berdasarkan perbedaan dosis masih terbatas. Penelitian ini bertujuan untuk membandingkan efek antiinflamasi dari beberapa dosis pemejanan ekstrak etanol kulit buah pomelo atau Citrus maxima (Burm). Merr. pada tikus putih jantan galur Wistar dengan metode carrageenan-induced hind paw edema. Volume edema berbeda secara signifikan antara kelompok ekstrak dengan kontrol negatif CMC-Na pada menit ke-120 (p=0,013). Penghambatan inflamasi terendah hingga tertinggi ditimbulkan oleh ekstrak dosis 100, 400, dan 200 mg/kg secara berturut-turut. Jadi, efek antiinflamasi berdasarkan perbedaan dosis pada penelitian ini bersifat non-linear.
Co-Authors Agustina Nila Yuliawati Anak Agung Ngurah Putra Riana Prasetya Dewa Ayu Arimurni Gusti Ayu Dewi Lestari I Gede Krisna Yudiarta Made Dwi Pradipta Wahyudi S Ni Ketut Esati Ni Ketut Sukarmini Ni Komang Eni Astari Ni komang yoni widyawati Ni Made Rai Yuliani Ni Nyoman Dina Saniasih Ni Putu Ratna Mulia Adnyani Ni Putu Sudiasih Putu Dian Marani Kurnianta Putu Indra Cyntia Dewi Rensiana Kartini Pandi Repining Tiyas Sawiji