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Fat free mass index as parameter for nutritional status in non-dialysis chronic kidney disease patients stage 3, 4 and 5 Kumala, Meilani; Lukito, Widjaja; Sastroamidjojo, Soemilah; Prodjosudjadi, Wiguno
Medical Journal of Indonesia Vol 17, No 4 (2008): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1587.488 KB) | DOI: 10.13181/mji.v17i4.325

Abstract

The aim of this study is to obtain body composition parameters for early detection of PEM in non dialysis CKD (ND-CKD) patients. The study was carried out using the cross sectional design. The subjects of the study consist of 45 ND-CKD patients and 45 healthy subjects matched for age, gender, height and body mass index (BMI). The nutritional status of patients and healthy subjects were classified based on BMI (WHO, 1995) into low, normal and high nutritional status groups. Fat free mass (FFM), FFM-index (FFM-I) and percentage of fat mass (FM percentage) in patients measured by anthropometric technique showed no significant difference with healthy subjects. Using the BIA  method, FFM and FFM-I were significantly lower in the ND-CKD patients compared to the healthy subjects (p < 0,05). Significant difference in FFM, FFM-I, FM and FM percentage was observed between the patients with different nutritional status. (p < 0,001). Trend analysis statistical test showed that there is linear correlation of FFM, FFM-I and FM with nutritional status classification. FFM, FFM-I, FM and FM percentage in ND-CKD patients were not significantly different between the three stages of CKD. There was an acceptable degree of agreement between BMI with FFM-I for nutritional assessment in ND-CKD patients. The Receiver Operating Curve test showed the cut off points of FFM-I 14.23 kg/m2 to differentiate undernutrition and normal nutritional status in ND-CKD patients. This study showed FFM-I has good correlation with BMI and can be used to differentiate degrees of nutritional status in stage 3, 4 and 5 ND-CKD  patients. FFM-I considered predictor parameters for nutritional status screening in ND-CKD patients. (Med J Indones 2008; 17: 240-7)Keywords: Non dialysis chronic kidney disease, protein energy  malnutrition, body composition, fat free mass, fat free mass index
Efek Lignan Terhadap Resiko Kanker Mammae Kumala, Meilani
Indonesian Journal of Cancer Vol 2, No 1 (2008): Jan - Mar 2008
Publisher : "Dharmais" Cancer Center Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1595.44 KB)

Abstract

Lignan merupakan metabolit sekunder dari tumbuh-tumbuhan dan termasuk kelompok fitoestrogen. Secoisolariciresinol (SECO) dan Matairesinol (MAT) merupakan prekursor mammalian lignan yang utama dan pertama diidentifikasi. Kedua prekursor tersebut banyak terdapat pada bahan makanan asal tumbuh-tumbuhan terutama yang kaya akan serat seperti biji-bijian, padi-padian, sayuran dan buah-buahan. Flaxseed merupakan bahan makanan sumber yang mempunyai kandungan lignan paling tinggi. Dalam saluran cerna kedua prekursor tersebut mengalami serangkaian metabolisme dan dengan bantuan mikronora dikonversi menghasilkan mammalian lignan yang mempunyai struktur menyerupai estrogen endrogen. Enterolignan mempunyai berbagai aktivitas biologik meliputi menghambat ikatan estrogen dengan reseptornya, menstimulasi produksi sex hormone-binding globulin, menghambat pembentukan enzim aromatase dan meningkatkan rasio 2-OHEl:16a-OHEl. Penelitan pada hewan dan manusia menunjukkan enterolignan mempunyai efek protektif terhadap kanker mammae. Aktivitas biologik enterolignan diduga berperan dalam mekanisme protektif terhadap risiko kanker mammae.Kata kunci: lignan, mammalian lignan, enterolignan, enterolakton, enterodiol, kanker mammae
HUBUNGAN STATUS GIZI, LINGKAR PINGGANG, DAN PROFIL LIPID TERHADAP HIPERTENSI PADA USIA PRODUKTIF BERPENGHASILAN RENDAH Kumala, Meilani; Lontoh, Susy Olivia; Novendy, Novendy
Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan Vol 5, No 1 (2021): Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan
Publisher : Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jmstkik.v5i1.9930

Abstract

Background: The prevalence of hypertension in the world today increases year by year. Monitoring data of non communicable diseases (NCD), 2017 shows that the number and risk of death for Indonesian people in productive age is quite high. Research on the relationship between risk factors and hypertension in low-income productive age communities in Indonesia has not been widely studied. Objective: This study aims to determine the relationship between nutritional status, waist circumference (WC) and lipid profile with hypertension in people of low income productive age. Methods: The design of this study was cross sectional. Identity data were collected through interview, blood pressure, anthropometry, waist circumference data were obtained by measuring and blood lipid profile, fasting blood sugar data were carried out by laboratory test. The data that had been obtained were tested using Fisher’s exact test. Results: As many as 50% of 62 subjects had hypetension, 38.7% of subjects had overweight, 33,87% of subjects had obesity and 61.9% of subjects had WC above normal or including central obesity. As many as 37.1% of subjects had hypercholesterolemia, 90.3% had low density lipoproteinemia (LDL) above normal, 16.1% of subjects had high density lipoproteinemia (HDL) below normal and 22.6% of subjects had hypertriglyceridemia. The results of Fisher's exact test showed that there was no relationship between nutritional status, WC and lipid profiles with hypertension. The prevalence odds ratio (POR) showed that subjects with over nutrition and obesity have a 1.63 times risk of developing hypertension; subjects with central obesity had a 1.73 times risk of developing hypertension; subjects with hypercholesterolemia had a 2.7-fold risk of developing hypertension and subjects with high LDL had 2.15 times the risk of developing hypertension, while POR of HDL and triglycerides showed a neutral value or not a risk factor for hypertension. Conclusion: Nutritional status, WC, lipid profile have no relationship with hypertension in low-income productive age people in Indonesia. Based on the POR, it was found that obesity, WC, cholesterol and LDL were risk factors for hypertension, whereas triglycerides and HDL did not affect the incidence of hypertension Keywords: nutritional status; waist circumferences; lipid profile; productive age; low income AbstrakLatar Belakang: Pevalensi hipertensi di dunia dewasa ini meningkat dari tahun ke tahun. Data monitor kemajuan penyakit tidak menular (PTM), 2017 menunjukkan bahwa angka dan risiko kematian masyarakat dengan usia produktif di Indonesia cukup tinggi.Penelitian hubungan faktor risiko terhadap hipertensi pada masyarakat usia produktif berpenghasilan rendah di Indonesia belum banyak dikaji lebih dalam. Tujuan: Penelitian yang dilakukan untuk mengetahui hubungan status gizi, lingkar pinggang (Lpi) dan profil lipid dengan hipertensi pada masyarakat usia produktif berpenghasilan rendah. Metode: Desain penelitian ini adalah potong lintang. Data identitas dikumpulkan melalui wawancara, data tekanan darah, antropometri, lingkar pinggang diperoleh dengan melakukan pengukuran dan data profil lipid darah, gula darah puasa dilakukan dengan pemeriksaan laboratorium. Data yang telah diperoleh, diuji menggunakan uji Fisher’s exact. Hasil: Sebanyak 50% dari 62 subjek mengalami hipertensi, 38,7% subjek mempunyai status gizi berlebih, 33,9% subjek termasuk obesitas dan 61,9% subjek mempunyai Lpi di atas normal atau obesitas sentral. Sebanyak 37,1% subjek mengalami hiperkolesterolemia, 90,3% mempunyai low density lipoproteinemia (LDL) di atas normal, 16,1% subjek mempunyai high density lipoproteinemia (HDL) dibawah normal dan 22,6% subjek mengalami hipertrigliseridemia. Hasil uji Fisher’s exact menunjukkan tidak terdapat hubungan antara status gizi, Lpi dan profil lipid dengan hipertensi. Prevalence odds ratio menunjukkan subjek dengan status gizi berlebih dan obesitas mempunyai risiko 1,63 kali mengalami hipertensi; subjek dengan obesitas sentral mempunyai risiko 1,73 kali mengalami hipertensi; subjek dengan hiperkolesterolemia mempunyai risiko 2,7 kali mengalami hipertensi dan subjek dengan LDL yang tinggi mempunyai risiko 2,15 kali mengalami hipertensi, sedangkan POR HDL dan trigliserida memperlihatkan tidak merupakan faktor risiko hipertensi. Kesimpulan: Status gizi, Lpi, profil lemak darah tidak mempunyai hubungan dengan kejadian hipertensi pada masyarakat usia produktif berpenghasilan rendah. Gizi lebih dan obesitas, Lpi, kolesterol dan LDL merupakan faktor risiko kejadian hipertensi sedangkan, triglieserida dan HDL tidak memengaruhi kejadian hipertensi.
GAMBARAN TINGKAT AKTIFITAS FISIK PADA MASYARAKAT KELURAHAN TOMANG JAKARTA BARAT Lontoh, Susy Olivia; Kumala, Meilani; Novendy, Novendy
Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan Vol 4, No 2 (2020): Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan
Publisher : Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jmstkik.v4i2.8728

Abstract

Lack of physical activity is a risk factor for increased incidence of coronary heart disease (CHD), type 2 diabetes mellitus (T2DM), breast cancer, colon cancer and reduced life expectancy. Regular and adequate levels of physical activity are essential to reduce the risk of non-communicable diseases. Kelurahan Tomang has an urban area and is an urban area and tends to be a sedentary life style. Data regarding the description of physical activity in the Tomang Village, West Jakarta is still limited. This study aims to determine the level of physical activity in the community of Tomang Village, West Jakarta. This research is an observational analytic study with a cross-sectional design. The study was conducted on 181 subjects and subject taking was done by consecutive sampling. Subjects in this study were aged from 20 years - 45 years with an average age of 35.1 ± 6.79 years, the majority were women as much as 55.8% and 78.5% of the subjects were married. Judging from the level of education, dominated by high school education / equivalent, the average monthly income of 42.9% of the subjects earned Rp. 3,000,001,-Rp. 4,000,000, - and most of the subjects worked as housewives and 43.1 % of subjects who did not exercise. The results of the measurement of the subject's physical activity level showed that 59.7% of subjects who had light activity and sex and type of work had an effect on the lack of physical activity Keywords: physical activity, sedentary life style ABSTRAKAktifitas fisik yang kurang  menjadi  faktor risiko untuk peningkatan kejadian penyakit jantung koroner (PJK), diabetes mellitus tipe 2 (T2DM), kanker payudara, kanker usus besar dan mengurangi harapan hidup. Tingkat aktifitas fisik yang teratur dan memadai sangat penting untuk mengurangi risiko penyakit tidak menular. Kelurahan Tomang berwilayah diperkotaan serta merupakan daerah urban dan  cenderung  sedentary life style. Data mengenai gambaran aktifitas fisik di lingkungan Kelurahan Tomang Jakarta Barat masih terbatas.  Penelitian ini bertujuan untuk mengetahui gambaran tingkat aktifitas fisik pada masyarakat kelurahan Tomang Jakarta Barat. Penelitian yang dilakukan merupakan penelitian analitik observational dengan disain potong lintang. Penelitian dilakukan pada 181  subyek dan pengambilan subjek dilakukan secara consecutive sampling.  Subjek  dalam penelitian ini berusia mulai dari 20 tahun - 45 tahun dengan usia rata-rata adalah 35.1 ± 6,79 tahun, mayoritas adalah perempuan  sebanyak 55,8 % dan  78,5 %  subjek menikah. Dilihat dari jenjang pendidikan, didominasi dengan pendidikan SMA/sederajat, rata-rata penghasilan perbulan 42,9 % subjek berpenghasilan Rp.3.000.001,-Rp.4.000.000,- dan  sebagian besar  subjek bekerja sebagai ibu rumah tangga serta  43,1%subjek  yang tidak melakukan olahraga. Hasil pengukuran tingkat aktifitas fisik subjek terlihat bahwa 59,7 % subjek yang memiliki aktifitas ringan dan jenis kelamin dan jenis pekerjaan berpengaruh terhadap kurangnya aktifitas fisik.
Efek Lignan Terhadap Resiko Kanker Mammae Meilani Kumala
Indonesian Journal of Cancer Vol 2, No 1 (2008): Jan - Mar 2008
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1595.44 KB) | DOI: 10.33371/ijoc.v2i1.32

Abstract

Lignan merupakan metabolit sekunder dari tumbuh-tumbuhan dan termasuk kelompok fitoestrogen. Secoisolariciresinol (SECO) dan Matairesinol (MAT) merupakan prekursor mammalian lignan yang utama dan pertama diidentifikasi. Kedua prekursor tersebut banyak terdapat pada bahan makanan asal tumbuh-tumbuhan terutama yang kaya akan serat seperti biji-bijian, padi-padian, sayuran dan buah-buahan. Flaxseed merupakan bahan makanan sumber yang mempunyai kandungan lignan paling tinggi. Dalam saluran cerna kedua prekursor tersebut mengalami serangkaian metabolisme dan dengan bantuan mikronora dikonversi menghasilkan mammalian lignan yang mempunyai struktur menyerupai estrogen endrogen. Enterolignan mempunyai berbagai aktivitas biologik meliputi menghambat ikatan estrogen dengan reseptornya, menstimulasi produksi sex hormone-binding globulin, menghambat pembentukan enzim aromatase dan meningkatkan rasio 2-OHEl:16a-OHEl. Penelitan pada hewan dan manusia menunjukkan enterolignan mempunyai efek protektif terhadap kanker mammae. Aktivitas biologik enterolignan diduga berperan dalam mekanisme protektif terhadap risiko kanker mammae.Kata kunci: lignan, mammalian lignan, enterolignan, enterolakton, enterodiol, kanker mammae
Relationship of Caffeinated Beverage Intake with Sleep Quality of 2020 Students' Faculty of Medicine Tarumanagara University Wendy Tan; Meilani Kumala
Budapest International Research and Critics Institute-Journal (BIRCI-Journal) Vol 5, No 3 (2022): Budapest International Research and Critics Institute August
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v5i3.6470

Abstract

Sleep is a condition in which a person becomes less aware of something. Short rest periods (<7 hours) can increase the risk of death and have been considered a major risk factor for damaging the endocrine system, immune system, nervous system, and cardiovascular system. Many factors affect sleep duration and sleep quality in adults and children, including the use of caffeinated beverages. The purpose of this study was to determine whether there was a relationship between the intake of caffeinated beverages and the sleep quality of the 2020 students of the Faculty of Medicine, Tarumanagara University. The research is a descriptive-analytic cross-sectional study. Data was collected by distributing g-form to respondents. The collected data were inputted and analyzed using SPSS with Chi-Square and Fisher's Exact as an alternative analysis for cells with an expected of less than five. The results of this study showed that 41.3% of respondents had good sleep quality, and 58.7% of respondents had poor sleep quality. There is a significant relationship between coffee intake and sleep quality (p-value = 0.044), and there is no significant relationship between intake of tea, chocolate drinks, soft drinks, and energy drinks with sleep quality. The value of the prevalence ratio of caffeinated beverages intake with sleep quality is greater than one, which indicates caffeinated beverages are a risk for poor sleep quality.
PROFIL ANTROPOMETRIK, VITAMIN D, B12, FOLAT, DAN FERITIN PASIEN OBES PRABEDAH BARIATRIK DI POLIKLINIK GIZI RUMAH SAKIT SUMBER WARAS Anastasia Hayuningtyas; Lady Dhita Alfara; Tjandraningrum; Victor Tambunan; Lukman Halim; Meilani Kumala; Johana Titus
IJCNP : INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN Vol 6 No 1 (2023): IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN)
Publisher : Perhimpunan Dokter Gizi Klinik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54773/ijcnp.v6i1.183

Abstract

Obese patients, especially patients with severe obesity and requiring bariatric surgery, have a high prevalence of nutrient deficiencies. This study aims to determine some of the basic characteristics of patients undergoing bariatric surgery so that they can be used as supporting data for post-bariatric surgery nutrition medical therapy, particularly in the provision of food sources and micronutrient supplementation which can be deficient due to anatomic and physiological alterations after the surgery. The study was conducted on 55 preoperative bariatric patients by assessing age, gender, and degree of obesity based on body mass index (BMI), serum vitamin D and B12 levels, erythrocyte folic acid, and serum ferritin of subjects. The study is descriptive with a cross-sectional design. Subjects were taken by consecutive sampling. The results showed that the mean age of preoperative bariatric patients was 36 ± 7.1 years; most (85.5%) were women. Most subjects (34.5%) had BMI of 35­–39.9 kg/m2. Vitamin D deficiency was present in most (75.6%) of the study subjects, but most had serum vitamin B12 levels, erythrocyte folic acid levels, and serum ferritin levels within normal limits. This study shows that the basic profile of patients undergoing bariatric surgery is primarily late adults, classified as severe obese and having vitamin D deficiency. Keywords: Obesity, Prebariatric, Serum Vitamin D, Serum Vitamin B12, Erythrocyte Folic Acid, and Serum Ferritin.