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T.N. Saifullah Sulaiman
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Other

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EFEK GEL EKSTRAK HERBA PEGAGAN (Centella asiatica L. Urban) DENGAN GELLING AGENT HIDROKSIPROPIL METHYLCELLULOSE TERHADAP PENYEMBUHAN LUKA BAKAR PADA KULIT PUNGGUNG KELINCI Tanti Azizah Sujono; Ullya Nur Wahyu Hidayah; T.N. Saifullah Sulaiman
Biomedika Vol 6, No 2 (2014): Biomedika Agustus 2014
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v6i2.276

Abstract

Pegagan (Centella asiatica L. Urban) contain saponin asiaticoside, which is a structural protein. The compound plays a role in the wound healing process by the formation of collagen. This research was conducted to determine the effect of wound healing of burns on New Zealand male rabbits using gel extract of Pegagan (Centella asiatica L. Urban) herbs using hydroxypropyl methylcellulose (HPMC) as gelling agent. This research was an experimental with the same subject design, using � ve male New Zealand rabbits to test the wound healing of burns, and the backs of each rabbit were divided into six treatment i.e : positive control (Bioplasenton), negative control (no treatment), control HPMC base (no extract), and three formula with herbal extracts of Centella asiatica with a concentration of gelling agent HPMC 8%, 9%, and 10% respectively. Gel was applied to the back of rabbits with the use ± 0.3 grams once daily until the wound diameter equal to zero or until healed. The data was analyzed by one way anava with a 95% confidence level. The result showed that of the gelling agent HPMC concentration effect on the increased the viscosity, and decreased the spreadability and the burn wound healing time is a longer. Gel herb pegagan extract (Centella asiatica L. Urban) with a gelling agent HPMC concentration of 8% (17,60±1,14 days) most effectively heal burns compared to the concentration of 9% (19,40 ±1,14 days) and concentration 10% (20,40±1,14 days).Keywords: Centella asiatica L. Urban, gel, hydroxypropyl methylcellulose, burns.
OPTIMASI STARCH 1500® DAN CROSPOVIDONE PADA FORMULASIORALLY DISINTEGRATING TABLET (ODT) ANTASIDA Dea Gita Ananthi; T.N. Saifullah Sulaiman; Ishak Lewi
Media Farmasi Indonesia Vol. 11 No. 1 (2016): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (256.128 KB)

Abstract

SARIGastritis atau secara umum dikenal dengan istilah sakit “maag” ialahperadangan pada dinding lambung terutama pada selaput lendir lambung.Penyakitgastritis umumya diatasi dengan penggunaan antasida yang merupakan kombinasiantara Aluminium Hidroksida dan Magnesium Hidroksida.Orally DisintegratingTablet diketahui dapat hancur atau melarut dalam mulut tanpa memerlukanair.Antasida diformulasikan dalam bentuk sediaan Orally Disintegrating Tabletdiharapkan mampu memberikan onset yang cepat dengan penggunaan yang lebihpraktis.Diperlukan eksipien berupa superdisintegrant untuk dapat meningkatkanwaktu hancurnya.Penelitian ini bertujuan untuk mengetahui pengaruh dari Starch1500® dan Crospovidone sebagai superdisintegrant serta interaksi keduanya danmenentukan formula optimum pada karakteristik fisik Orally DisintegratingTablet (ODT) Antasida.Optimasi Starch 1500® dan Crospovidone dilakukandengan metode factorial design.Konsentrasi Starch 1500® yang digunakan adalah5% dan 10%, sedangkan Crospovidone 2% dan 5%.Orally Disintegrating Tablet(ODT) Antasida dibuat dengan metode kempa langsung dan formula optimumdiperoleh dari respons daya alir, kandungan lembab, kekerasan, kerapuhan, waktuhancur serta wetting time. Formula optimum yang didapat adalah komposisiStarch 1500® sebesar 6,467% danCrospovidone sebesar 2,000%.
Co-Authors Dea Gita Ananthi Ishak Lewi Tanti Azizah Sujono Ullya Nur Wahyu Hidayah