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All Journal PROSIDING SEMINAR NASIONAL WARTA Biomedika Pharmacon INDONESIAN JOURNAL OF PHARMACY Jurnal Penelitian Sains Teknologi JPSCR : Journal of Pharmaceutical Science and Clinical Research JURNAL ILMU KEFARMASIAN INDONESIA Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium
Tanti Azizah Sujono
Universitas Muhammadiyah Surakarta
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Engineering Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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PENGEMBANGAN POTENSI EKSTRAK KULIT BUAH RAMBUTAN SEBAGAI BAHAN OBAT HERBAL ANTIHIPERKOLESTEROL Muhtadi, .; Haryoto, .; Sujono, Tanti Azizah; Indaryudha, Peni; Suhendi, Andi
Biomedika Vol 5, No 2 (2013): Biomedika Agustus 2013
Publisher : Universitas Muhamadiyah Surakarta

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Abstract

The rind of rambutan fruit (Nephelium lappaceum L.) has been reported to have a very strong antioxidant activity with IC50 value of 7.74 μg / mL. The fruit contains  avonoids and phenolic . This compounds are potentially as hypolipidemic effect. This study aims to determine the hypolipidemic effect of 96% of ethanolic extract of rind of rambutan fruit in wistar strain male rats. This research method is the pre- and post-control group design. 25 rats were divided into 5 groups. Group I (negative control) were treated by a solution of 0.5% CMC-Na, group II (positive control) were treatedby cholestyramine 0.8 kg / kg, whereas group III, IV and V treated by 96% of ethanolic extract of rind of rambutan with a dose of 125 , 250, and 500 mg / kg respectively. hiperkolesterlemia induction is done by giving a high cholesterol diet and feed for 4 weeks. High-cholesterol diet consists of cooking oil, quail egg yolk, water, PTU and feed high cholesterol consisting of margarine and standard feed. Treatment of mice was conducted for 2 weeks. The results showed that the 96% of ethanolic extract of rind of rambutan fruit with a dose of 125, 250, and 500 mg / kgbw have antihyperkolesterol activity 21.39 ± 6.61%, 31.15 ± 18.15%, and 60.75 ± 8, 26%.Keywords: Antihypercholestrol, Nephelium Lappaceum L., High-cholesterol diet
EFEK ANTIINFLAMASI INFUSA RIMPANG TEMU PUTIH (Curcuma zedoaria (Berg) Roscoe) PADA TIKUS YANG DIINDUKSI KARAGENIN Sujono, Tanti Azizah; Patimah, Raudatul; Yuliani, Ratna
Biomedika Vol 4, No 2 (2012): Biomedika Agustus 2012
Publisher : Universitas Muhamadiyah Surakarta

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Abstract

In-flammation is the body’s reaction to foreign substances that enter the body with signs of redness, heat, swelling, pain, and impaired organ functions. Curcuma rhizome including medicinal plants that have properties relieve the pain and inflammation of the skin. The purpose of this research was to examine the anti-iflammation effect of Curcuma zedoaria (Berg) Roscoe Rhizome infusion on carrageenan induced paw edema in rats. This research used experimental method with completely randomized design. Twenty five healthy Wistar male rats, 2-3 months old and 150-250 g divided into five groups and each group consist of 5 rats. Rats in group I that served as negative control were given 2.5 mL/200gbw of aquadest. Rats in group II as positive control were given sodium diclofenac with dose of 6.75 mg/kgbw. Group III, IV, and V were given Curcuma zedoaria (Berg) Roscoe Rhizome infusion with dose of 0.625, 1.250 and 2.500 g/kgbw, respectively. Treatments were given per oral 1 hour before injection of 0.1 ml carrageenan 1% subplantar. Rat paw edema volume was measured before and after carrageenan injection. The measurement was done every 0.5 hour for 6 hours observation. Area Under the Curve (AUC) that is calculated from paw edema volume data, was use to calculate percentage of anti-inflammatory effect. Data were analyzed with one way Anova and Least Signifi cant Difference with confi dence level 95%. Infusion of Curcuma zedoaria Rhizome with doses of 0,625, 1,250, and 2,500 g/kgbw had anti-inflammatory effect in Wistar male rats which were induced by Carrageenan 1%. Percentage of anti-inflammation effect (44,16+5,11)%, (48,70+7,05)%, (59,09+9,61)% respectively and the effects were equivalent with positive control.Key words: Anti-inflammation, Curcuma zedoaria (Berg) Roscoe, infusion, Carrageenan.
EFEK GEL EKSTRAK HERBA PEGAGAN (Centella asiatica L. Urban) DENGAN GELLING AGENT HIDROKSIPROPIL METHYLCELLULOSE TERHADAP PENYEMBUHAN LUKA BAKAR PADA KULIT PUNGGUNG KELINCI Sujono, Tanti Azizah; Hidayah, Ullya Nur Wahyu; Sulaiman, T.N. Saifullah
Biomedika Vol 6, No 2 (2014): Biomedika Agustus 2014
Publisher : Universitas Muhamadiyah Surakarta

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Abstract

Pegagan (Centella asiatica L. Urban) contain saponin asiaticoside, which is a structural protein. The compound plays a role in the wound healing process by the formation of collagen. This research was conducted to determine the effect of wound healing of burns on New Zealand male rabbits using gel extract of Pegagan (Centella asiatica L. Urban) herbs using hydroxypropyl methylcellulose (HPMC) as gelling agent. This research was an experimental with the same subject design, using � ve male New Zealand rabbits to test the wound healing of burns, and the backs of each rabbit were divided into six treatment i.e : positive control (Bioplasenton), negative control (no treatment), control HPMC base (no extract), and three formula with herbal extracts of Centella asiatica with a concentration of gelling agent HPMC 8%, 9%, and 10% respectively. Gel was applied to the back of rabbits with the use ± 0.3 grams once daily until the wound diameter equal to zero or until healed. The data was analyzed by one way anava with a 95% confidence level. The result showed that of the gelling agent HPMC concentration effect on the increased the viscosity, and decreased the spreadability and the burn wound healing time is a longer. Gel herb pegagan extract (Centella asiatica L. Urban) with a gelling agent HPMC concentration of 8% (17,60±1,14 days) most effectively heal burns compared to the concentration of 9% (19,40 ±1,14 days) and concentration 10% (20,40±1,14 days).Keywords: Centella asiatica L. Urban, gel, hydroxypropyl methylcellulose, burns.
PELATIHAN PEMERIKSAAN TAJAM PENGLIHATAN PADA SISWA KELAS 5 SD GEDONGAN I, COLOMADU, KARANGANYAR Sutrisna, Em; Hanwar, Dedi; Indrayudha, Peni; Sujono, Tanti Azizah
WARTA WARTA Volume 10, Nomor 1, Maret 2007
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (24.037 KB) | DOI: 10.23917/warta.v10i1.3210

Abstract

Seeing is crucial aspect in life includes in the field of education. Ifit is not cured the reduction of  sharpness of seeing/visus can affect thestudent ability to study. This action is done to detect  this reduction early.Therefore, the eyes will not be getting worse. The research is done bytraining and demonstrating how to check visus. The location of the researchis SD Gedongan I, Gedongan, Colomadu, Karanganayar. The 31 studentsare checked. The result is that there are 3 students have visus with miop.All the students can participate in this research well.
Aktivitas Antihiperurisemia Ekstrak Etanol Kulit Buah Rambutan (Nephelium lappaceum L.) dan Jeruk Manis (Citrus Sinensis L. Osbeck) pada Mencit Jantan Galur SWISS Sujono, Tanti Azizah; Muhtadi, Muhtadi; Sativa, Wieke Rachma
Jurnal Penelitian Sains Teknologi Volume 13, No. 1, April 2012
Publisher : Muhammadiyah University Press

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Abstract

Kulit buah rambutan dan jeruk manis mengandung senyawa yangdiduga dapat berperan sebagai antihiperurisemia seperti asam galat,kaempferol, luteolin, hesperidin dan rutin. Namun belum ada penelitianmengenai potensi antihiperurisemia kulit buah rambutan dan jerukmanis. Tujuan dari penelitian ini untuk mengetahui pengaruh dariekstrak etanol kulit buah rambutan dan jeruk manis pada mencit jantangalur swiss yang telah diinduksi dengan kalium oksonat secaraintraperitoneal. Pengujian efek ekstrak etanol kulit buah rambutan danjeruk manis dilakukan secara eksperimental dengan rancangan post testcontrol group design menggunakan Empat puluh ekor mencit jantandibagi dalam 8 kelompok yaitu kelompok kontrol positif (allopurinoldosis 10 mg/kgBB), kontrol negatif (CMC Na 0,5%), tiga kelompokperlakuan masing-masing diberikan ekstrak etanol kulit buah rambutandosis 125; 250 dan 500 mg/kgBB dan tiga kelompok perlakuan lainnyamasing-masing diberikan ekstrak etanol kulit buah jeruk manis dosis125; 250 dan 500 mg/kgBB. Konsentrasi asam urat serum dianalisisdengan metode enzimatis TBHBA pada panjang gelombang 546 nm.Hasil penelitian menunjukkan bahwa ekstrak etanol kulit buahrambutan dan jeruk manis memiliki pengaruh dalam menurunkankadar asam urat serum mencit jantan galur Swiss yang telah dibuathiperurisemia dengan diinduksi potassium oxonate.
Effect Test Stimulant of Curcuma Rhizome Infusion (Curcuma xanthorrhiza Roxb.) On Male Mice Swiss Strain Tary, Neni Lugki Nian; Sujono, Tanti Azizah
Pharmacon: Jurnal Farmasi Indonesia Vol 14, No 1 (2017)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v14i1.540

Abstract

The used of plants efficacious as medicines in the prevention of health problems had been known for along time the Indonesian people. The utilization of plants as medicine was based on the experience passeddown from generation to generation. The used of traditional medicines relatively favored by the people,the underlying factor are traditional medicines have less side effects than the modern medicines if usedappropriately. Curcuma (Curcuma xanthorrhiza Roxb.) used as refreshment which had stimulant effect..Stimulant was a substance that can stimulated the central nervous system which can speed up the processesin the body and minimize fatigue. Need to research the effects of stimulant infusion of curcuma rhizome.The research was conducted experimental methods pre-test and post-test. Twenty-five male mice Swissstrain used as experimental animals, which are divided into five groups, positive control (caffeine 100mg /kg BW), negative control (distilled water 0,5ml /20g BW), infusion of curcuma dose I (2.5 g/ kg BW), doseII (5g / kg BW), and dose III (10g / kg BW) respectively. Animal experiments tested using methods NatatoryExhaustion and treated with oral route. The effects of stimulant tired was calculated the time differencebefore and after treatment. The data obtained were analyzed non-parametric statistical tests, it’s KruskalWallis and Mann Whitney with a 95% confidence level. Infuse curcuma rhizome had the stimulant effect,the effect was obtained by increased the dose. At doses of 2.5 g / kg BW, 5g / kg BW, and 10 g / kg BW wasprovide a stimulant effect respectively by 2.82 minutes, 3.71 minutes and 4.94 minutes. Stimulant effect doseII and III had a greater effect than the positive control (p<0,05), the dose I had similar effect compare withcontrol positive (p>0,05). 
EFEK GEL EKSTRAK HERBA PEGAGAN (Centella asiatica L. Urban) DENGAN GELLING AGENT HIDROKSIPROPIL METHYLCELLULOSE TERHADAP PENYEMBUHAN LUKA BAKAR PADA KULIT PUNGGUNG KELINCI Sujono, Tanti Azizah; Hidayah, Ullya Nur Wahyu; Sulaiman, T.N. Saifullah
Biomedika Vol 6, No 2 (2014): Biomedika Agustus 2014
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v6i2.276

Abstract

Pegagan (Centella asiatica L. Urban) contain saponin asiaticoside, which is a structural protein. The compound plays a role in the wound healing process by the formation of collagen. This research was conducted to determine the effect of wound healing of burns on New Zealand male rabbits using gel extract of Pegagan (Centella asiatica L. Urban) herbs using hydroxypropyl methylcellulose (HPMC) as gelling agent. This research was an experimental with the same subject design, using ? ve male New Zealand rabbits to test the wound healing of burns, and the backs of each rabbit were divided into six treatment i.e : positive control (Bioplasenton), negative control (no treatment), control HPMC base (no extract), and three formula with herbal extracts of Centella asiatica with a concentration of gelling agent HPMC 8%, 9%, and 10% respectively. Gel was applied to the back of rabbits with the use ± 0.3 grams once daily until the wound diameter equal to zero or until healed. The data was analyzed by one way anava with a 95% confidence level. The result showed that of the gelling agent HPMC concentration effect on the increased the viscosity, and decreased the spreadability and the burn wound healing time is a longer. Gel herb pegagan extract (Centella asiatica L. Urban) with a gelling agent HPMC concentration of 8% (17,60±1,14 days) most effectively heal burns compared to the concentration of 9% (19,40 ±1,14 days) and concentration 10% (20,40±1,14 days).Keywords: Centella asiatica L. Urban, gel, hydroxypropyl methylcellulose, burns.
PENGEMBANGAN POTENSI EKSTRAK KULIT BUAH RAMBUTAN SEBAGAI BAHAN OBAT HERBAL ANTIHIPERKOLESTEROL Muhtadi, .; Haryoto, .; Sujono, Tanti Azizah; Indaryudha, Peni; Suhendi, Andi
Biomedika Vol 5, No 2 (2013): Biomedika Agustus 2013
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v5i2.266

Abstract

The rind of rambutan fruit (Nephelium lappaceum L.) has been reported to have a very strong antioxidant activity with IC50 value of 7.74 ?g / mL. The fruit contains ? avonoids and phenolic . This compounds are potentially as hypolipidemic effect. This study aims to determine the hypolipidemic effect of 96% of ethanolic extract of rind of rambutan fruit in wistar strain male rats. This research method is the pre- and post-control group design. 25 rats were divided into 5 groups. Group I (negative control) were treated by a solution of 0.5% CMC-Na, group II (positive control) were treatedby cholestyramine 0.8 kg / kg, whereas group III, IV and V treated by 96% of ethanolic extract of rind of rambutan with a dose of 125 , 250, and 500 mg / kg respectively. hiperkolesterlemia induction is done by giving a high cholesterol diet and feed for 4 weeks. High-cholesterol diet consists of cooking oil, quail egg yolk, water, PTU and feed high cholesterol consisting of margarine and standard feed. Treatment of mice was conducted for 2 weeks. The results showed that the 96% of ethanolic extract of rind of rambutan fruit with a dose of 125, 250, and 500 mg / kgbw have antihyperkolesterol activity 21.39 ± 6.61%, 31.15 ± 18.15%, and 60.75 ± 8, 26%.Keywords: Antihypercholestrol, Nephelium Lappaceum L., High-cholesterol diet
EFEK ANTIINFLAMASI INFUSA RIMPANG TEMU PUTIH (Curcuma zedoaria (Berg) Roscoe) PADA TIKUS YANG DIINDUKSI KARAGENIN Sujono, Tanti Azizah; Patimah, Raudatul; Yuliani, Ratna
Biomedika Vol 4, No 2 (2012): Biomedika Agustus 2012
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v4i2.253

Abstract

In-flammation is the body’s reaction to foreign substances that enter the body with signs of redness, heat, swelling, pain, and impaired organ functions. Curcuma rhizome including medicinal plants that have properties relieve the pain and inflammation of the skin. The purpose of this research was to examine the anti-iflammation effect of Curcuma zedoaria (Berg) Roscoe Rhizome infusion on carrageenan induced paw edema in rats. This research used experimental method with completely randomized design. Twenty five healthy Wistar male rats, 2-3 months old and 150-250 g divided into five groups and each group consist of 5 rats. Rats in group I that served as negative control were given 2.5 mL/200gbw of aquadest. Rats in group II as positive control were given sodium diclofenac with dose of 6.75 mg/kgbw. Group III, IV, and V were given Curcuma zedoaria (Berg) Roscoe Rhizome infusion with dose of 0.625, 1.250 and 2.500 g/kgbw, respectively. Treatments were given per oral 1 hour before injection of 0.1 ml carrageenan 1% subplantar. Rat paw edema volume was measured before and after carrageenan injection. The measurement was done every 0.5 hour for 6 hours observation. Area Under the Curve (AUC) that is calculated from paw edema volume data, was use to calculate percentage of anti-inflammatory effect. Data were analyzed with one way Anova and Least Signifi cant Difference with confi dence level 95%. Infusion of Curcuma zedoaria Rhizome with doses of 0,625, 1,250, and 2,500 g/kgbw had anti-inflammatory effect in Wistar male rats which were induced by Carrageenan 1%. Percentage of anti-inflammation effect (44,16+5,11)%, (48,70+7,05)%, (59,09+9,61)% respectively and the effects were equivalent with positive control.Key words: Anti-inflammation, Curcuma zedoaria (Berg) Roscoe, infusion, Carrageenan.
Efek Nefroprotektif Ekstrak Etanol Bawang Putih (Allium sativum L.) pada Tikus yang Diinduksi Gentamisin Sujono, Tanti Azizah; Rizki, Fanny Atika
Pharmacon: Jurnal Farmasi Indonesia Edisi Khusus: RAKERDA, SEMINAR, PID IAI
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v0i0.10510

Abstract

Gentamicin can induce damage to the kidney because of the accumulation of epithelial cells in the cortex. This accumulation can cause an increase in Reactive Oxygen Species (ROS), which in turn can trigger an increase in free radicals which causes a decrease in kidney function, which can be seen with Blood Urea Nitrogen (BUN) and sCr (serum creatinine) parameters. Garlic (Allium sativum L.) contains several bioactive compounds, including alliin, allisin, ajoene, and allil cysteine. The content of allisin has activity as an antioxidant. This study used a nephrotoxic mouse modelling method with 100 mg/kgBW of gentamicin induction intraperitoneally, then BUN and sCr levels were checked 24 hours after the 10th day induction. This study aimed to determine the effect of garlic ethanol extract in preventing the decline of renal function in rats induced by gentamicin with a parameter of BUN and sCr. The animal test were divided into 5 treatment groups, normal control group, negative controls, and three treatment groups at a dose of 50, 120, and 300 mg/kgBW for 10 days of concurrent treatment between extracts with gentamicin. The results of the study showed that garlic ethanol extract with a dose of  50, 120, 300 mg/kgBW was able to prevent a decrease  in kidney function due to the administration of gentamicin significantly when compared with negative controls (p 0,05).
Co-Authors . Haryoto . Haryoto, . . Muhtadi . MUHTADI A Anifatussaa'dah Agung Endro Nugroho Ahmad Fauzi Ambarwati Andi Suhendi Ardalia Rinanda Oktaviani Arief Nurrochmad Arifah Sri Wahyuni Azis Saifudin Burhanudin Ichsan Dedi Hanwar Dewi, Listiana Masyita Dwi Sarbini Eka Prasnaparamita W Em Sutrisna Endang Lukitaningsih Erna Herawati Fahriza Mei Trihatmoko Fanny Atika Rizki Faridita khoirun Nisa' Fidhia Nur Rifaini Haliza Arzeti Nurseptiria Haryoto - Haryoto Haryoto Haya Nabilah Utama Hidayah Karuniawati Ida Maesaroh Ika Trisharyanti Dian Kusumowati Khusnul Khotimah Laila Dzafira LANGKAH SEMBIRING Lina Ayu Kusumastuti Mariska Sri Harlianti Marsilia Rosa Sinensis HI Maryati Maryati Muhtadi - Muhtadi Muhtadi Neni Lugki Nian Tary Peni Indaryudha Peni Indaryudha, Peni Peni Indrayudha Raafika Studiviani Rahardian Surya Basusena Ratna Yuliani Ratna Yuliani Raudatul Patimah Raudatul Patimah, Raudatul Retno Sintowati - Rima Munawaroh Rizki Ainun Fitriani Rizki, Fanny Atika Sativa, Wieke Rachma Sayyidah Nurul Muslihah Sri Wahyuni Subagus Wahyuono T.N. Saifullah Sulaiman T.N. Saifullah Sulaiman, T.N. Saifullah Tary, Neni Lugki Nian Tia Mella Citra Tista Ayu Fortuna Ullya Nur Wahyu Hidayah Ullya Nur Wahyu Hidayah, Ullya Nur Wahyu Vitania Marsya