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All Journal Cermin Dunia Kedokteran The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia
Juferdy Kurniawan
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Health Professions Medicine & Pharmacology Public Health

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Pilihan Tatalaksana Penyakit Perlemakan Hati Non-Alkohol (Non-Alcoholic Fatty Liver Disease/ NAFLD) Imanuel Setiawan, Stefanus; Kurniawan, Juferdy
Cermin Dunia Kedokteran Vol 48, No 3 (2021): Obstetri dan Ginekologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (95.345 KB) | DOI: 10.55175/cdk.v48i3.1336

Abstract

Penyakit perlemakan hati non-alkohol (Non-alcoholic fatty liver disease/ NAFLD) merupakan kondisi adanya steatosis hepatik, inflamasi, dan kerusakan hepatosit (ballooning degeneration). NAFLD tidak hanya dianggap penyakit hati primer, tetapi juga merupakan bagian dari sindrom metabolik atau kondisi resistensi insulin dan penyakit terkait gaya hidup seperti diabetes, dislipidemia, dan hipertensi. Strategi tatalaksana NAFLD dimulai dari modifikasi gaya hidup, dapat dilanjutkan dengan terapi komponen sindrom metabolik, farmakoterapi, hingga penatalaksanaan sirosis.Non-alcoholic fatty liver disease refers to a steatosis in liver, associated with inflammation and destruction of hepatocyte (ballooning degeneration). NAFLD is considered as primary liver disease, but also as a component of metabolic syndrome related to insulin resistance and other life-style-related diseases i.e diabetes mellitus, dyslipidemia, and hypertension. Strategies in NAFLD management start with life-style modification, continued with pharmacological approaches targeting metabolic syndrome and complications related to cirrhosis.
Factors Associated with Surveillance for Early Detection of Hepatocellular Carcinoma in Liver Cirrhosis Patients Ario Perbowo Putra; Andri Sanityoso Sulaiman; Juferdy Kurniawan; Kuntjoro Harimurti
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 18, No 3 (2017): VOLUME 18, NUMBER 3, DECEMBER 2017
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (167.745 KB) | DOI: 10.24871/1832017153-158

Abstract

Background: Minimal number of KHS patients diagnosed through surveillance is thought to be the cause of continued low survival. It is important knowing the proportion of surveillance for early detection of KHS in patients with liver cirrhosis and related factors.Objective: Determine the proportion of surveillance for early detection of KHS in patients with liver cirrhosis and related factors.Method: Cross-sectional study of patients with liver cirrhosis at RSCM from January to December 2013. Data obtained from medical records and reconfirmed by telephone. Surveillance is required for abdominal ultrasound with or without AFP at least once a year within 3 years after that period. Factors studied were gender, ethnicity, education level, income level, availability of medical assurance, location of residence, surveillance education, cirrhosis etiology, and severity of cirrhosis. Then logistic regression test is used in the multivariate analysis.Results: From 200 patients, 50 patients (25,0%) underwent surveillance, 150 patients (75,0%) did not. Bivariate analysis resulted in 4 variables with p 0.25, gender (p = 0,056), ethnicity (p = 0, 231), surveillance education (p = 0,005), and severity of cirrhosis (p = 0, 005). Multivariate analysis resulted risk factors for surveillance were surveillance education (OR = 2,598; CI 95% (1,325 - 5,094), p = 0,005) and severity of cirrhosis (OR = 1.815; CI 95% = 1,210-2,724; p = 0,004).Conclusion: Surveillance education and severity of cirrhosis are factors associated with surveillance for early detection of KHS in liver cirrhosis patients.
Diarrhea in HIV Infection Juferdy Kurniawan; Marcellus Simadibrata; Teguh Karyadi; Kie Chen
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 10, ISSUE 1, April 2009
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/101200923-28

Abstract

During the last decade, there has been an increase of immunocompromized patients all around the world; that mostly due to pandemic of Human Immunodeficiency Virus (HIV) infection. Chronic diarrhea as one of common symptoms in patients with HIV infection has different etiology compared to immunocompetent patients. Initial approach of diarrhea in HIV infection may be conducted by evaluating the temporal relationship between the development of diarrhea and the administration of antiretroviral, especially the protease inhibitor agents; which is then followed by fecal analysis/examination for pathogenic bacteria and protozoa as well as endoscopy examination. Biopsy examination of intestinal mucosa is necessary for HIV enteropathy or diarrhea due to microsporidia, which is confirmed further by electron microscopy. The etiology of chronic diarrhea in HIV patients may also different, depend on the cluster of differentiation count value of all patients. Based on such differences, it is necessary  to  have  adequate  approach,   recognition  and  understanding  in the management of chronic diarrhea, especially for HIV patients. Keywords: diarrhea, infection, HI
Abnormal Liver Function in Predicting COVID-19 Patients’ Prognosis Sari, Sakinah Rahma; Kurniawan, Juferdy
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 1
Publisher : UI Scholars Hub

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Abstract

Despite of the high prevalence of liver enzyme elevation in COVID-19 patients, its effect on predicting COVID-19 patients’ prognosis was still debatable. This evidence-based case report aims to evaluate the effect of abnormal liver function in the prognosis of COVID-19 patients. Literature searching was performed on August 16-17 2021 using 3 databases: PubMed, Scopus, and Proquest. The articles selected by title/abstract screening, duplication elimination, and applying eligibility criteria were then appraised using Centre of Evidence Based Medicine (CEBM), University of Oxford. Some of the studies reported there were no significant difference in the prognosis of COVID-19 patient with and without abnormal liver function. However, most of the studies reported abnormal liver function as an independent poor prognosis predictor in COVID-19 patients. Based on the study with the highest level of evidence, the elevation of AST and ALT increase the risk of poor prognosis in COVID-19 patients [OR 2.98 (95% CI 2.35-3.77), p<0.0001) and OR 1.73 (95% CI 1.32-2.27, p<0.001)]. Based on the 34 studies appraised, we conclude that abnormal liver function will increase the risk of poor prognosis in COVID-19 patients. Thus, careful monitoring must be done in COVID-19 patients with abnormal liver function.
Comparison of Absolute Neutrophil Count between Hospital and Community Acquired Methicillin-Resistant Staphylococcus aureus Infection Kurniyanto, Kurniyanto; Santoso, Widayat Djoko; Nainggolan, Leonard; Kurniawan, Juferdy
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 4
Publisher : UI Scholars Hub

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Introduction. The virulence factors from community acquired-methicillin resistant Staphylococcus aureus (CA-MRSA) mainly due to toxins like Panton Valentin Leukocidin (PVL) and Phenol Soluble Modulin (PSM). Both of toxins cause decrease of value through neutrophil lysis. This study aimed to identify different value of absolute neutrophil count between hospital and community acquired MRSA. Methods. A cross sectional was conducted which included subjects who were infected by MRSA and hospitalized during 2012-2017. Classification of MRSA were divided due to its sensitivity and resistance to non-beta lactam antibiotics. Isolate that resistance to ≤ 2 antibiotics were classified as CA-MRSA. The others with resistance to ≥ 3 antibiotics were classified as hospital acquired MRSA. Absolute neutrophils count (ANC) were collected 24 hours from the positive MRSA culture. Data were analyzed by using independent T test and Mann-Whitney test. Results. We collected 62 subjects infected by MRSA which 35 subjects were HA-MRSA and 27 subjects were CA-MRSA. The median of ANC from CA-MRSA was 7,410.7 (1,147.3-26,560.2) and HA-MRSA was 16,198.0 (3,921.6-28,794.1) with p value < 0.001. Conclusion. There was a different value of absolute neutrophil count in infections due to community and hospital acquired MRSA.
Perkembangan Terapi Hepatitis B Kronis di Indonesia Kurniawan, Juferdy
Jurnal Penyakit Dalam Indonesia Vol. 8, No. 3
Publisher : UI Scholars Hub

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Abstract

Indonesia merupakan salah satu negara dengan prevalensi hepatitis B yang tinggi di Asia Tenggara (kedua setelah Vietnam). Berdasarkan Riskesdas yang dilakukan oleh Kementerian Kesehatan Republik Indonesia, pada studi yang dilakukan pada sampel darah PMI, 10 dari 100 orang Indonesia terinfeksi hepatitis B atau C. Maka dari itu, dibutuhkan penanganan yang ekstra untuk penanggulangan masalah infeksi hepatitis B
Co-Authors -, Gunawan - -, Gunawan - A, GM Yudi Prasetia Amin, Bany Faris Andri Sanityoso Andri Sanityoso Sulaiman Ario Perbowo Putra Ario Perbowo Putra, Ario Perbowo C Rinaldi A Lesmana Chairunisa, Shafira Chyntia Olivia Maurine Jasirwan, Chyntia Olivia Maurine Dewi ANGGRAENI Dewi Martalena Esthika Dewiasty, Esthika Felix Firyanto Widjaja Hanif, Muhammad Yusuf Imanuel Setiawan, Stefanus Irfan Kresnadi Irsan Hasan Karenina, Vannessa Kemal Fariz Kalista, Kemal Fariz Kie Chen Kresnadi, Irfan Kuntjoro Harimurti Kurniyanto, Kurniyanto Leonard Nainggolan Lutfie Lutfie, Lutfie Marcellus Simadibrata Marcellus Simadibrata Permatasari, Anggi Anggelina Prasetyadi, Yosafat Lambang Putri, Trivani Rino Alvani Gani Sari, Sakinah Rahma Simbolon, Agnes Elsha Maria Swaraghani, Dela Ryana Teguh Karyadi Widayat Djoko Santoso, Widayat Djoko