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Isolasi dan Uji Aktivitas Antioksidan Ekstrak Metanol Dari Buah Senduduk Bulu (Clidemia hirta (L.) D. Don) Haiyul Fadhli; Ihsan Ikhtiarudin; Putri Lestari
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 2 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i2.9846

Abstract

A study on isolation and antioxidant activity of secondary metabolit of methanol extract of fruit of Senduduk Bulu (Clidemia hirta (L.) D. Don) has been carried out. Senduduk bulu is used for folk medicine to many diseases. Flavonoid and phenolic has been reported to its activity as antioxidant. The aim of this research was to find antioxidant compound and antioxidant activity of this fruit. Isolation works were conducted using Vacuum Liquid Chromatography and Column Chromatography method. Antioxidant activity was determined using DPPH free radical scavenging methods. The isolation works afforded 10 mg of pure compound CHP1 which was obtained as white crystal, with its melting point of 165–167ºC, soluble in chloroform and slightly soluble in methanol. This compound gave positive reaction with Liebermann-Burchard (LB) reagent and concluded as terpenoid. Based on it UV spectrum, this compound showed a λ max of 316 nm. Its FT-IR spectrum showed appearence of some functional groups of OH, C-H aliphatic, C=O ester,C=C alkene, CH bending and C-O. The 1H-NMR spectrum showed the alkene protons and methyl protons which is a characteristic of terpenoid compounds. The pure compound (CHP1) provided a weak antioxidant activity with the IC50  of 327,01µg/mL.
UJI AKTIVITAS ANTIOKSIDAN DAN TABIR SURYA EKSTRAK ETANOL DAN FRAKSI DAUN TERAP (Artocarpus odoratissimus Blanco) Mustika Furi; Robby Feriansyah; Haiyul Fadhli; Rahayu Utami; Putri Lestari
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 15 No 2 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v15i2.159

Abstract

Plants from genus Artocarpus are known containing phenolic and flavonoid compounds that have potential as antioxidant and sunscreen agent. Terap is one of species plant of Artocarpus genus, which has latin name Artocarpus odorratissimus Blanco. This present study aims to determine the antioxidant and sunscreen activity of ethanol extract and fractions of terap’s leaves. The evaluation was conducted by in vitro assay, which were the antioxidant activity was tested using the DPPH method by Microplate Reader and the sunscreen activity was analyzed using UV-Vis spectrophotometer. The results indicated that ethanol extract, ethylacetate and butanol fractions afforded very strong category of antioxidant activity with IC50 values ​​of 44.04; 42.9 and 36.49 µg/mL, respectively, while moderate activity gave by n-hexane fraction with IC50 value of 168.31 µg/mL. As for the sunscreen activity test, the most potential activity exhibited by the ethylacetate fraction at tested concentrations of 500; 250; 200; and 150 µg/mL demonstrated SPF values of 39.45; 37.36; 33.27 and 26.14, respectively; with ultra protection category as well as showed %Te and %Tp values of <1% which categorized as sunblock.
Co-Authors Furi, Mustika Haiyul Fadhli Ihsan Ikhtiarudin Rahayu Utami Robby Feriansyah