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All Journal Folia Medica Indonesiana Journal of Agromedicine and Medical Sciences Global Medical and Health Communication Jurnal Media Gizi Indonesia (MGI) The Indonesian Biomedical Journal Sari Pediatri Paediatrica Indonesiana Health Notions Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Oto Rhino Laryngologica Indonesiana JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Majalah Biomorfologi (Biomorphology Journal) Indian Journal of Forensic Medicine & Toxicology Jurnal Pengabdian Kesehatan Masyarakat
Mahrus A. Rahman
Departement Of Child Health, Dr. Soetomo General Hospital, Faculty Of Medicine, Universitas Airlangga, Jl. Mayjen Prof. Dr. Moestopo No. 6-8, Surabaya
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : The Indonesian Biomedical Journal

 1 
Comparison of Angiotensin-Converting Enzyme Inhibitor (ACEI) and Angiotensin Receptor Blocker (ARB) for Heart Failure Treatment in Congenital Heart Diseases with Left-to-Right Shunt Alit Utamayasa; Mahrus Ahmad Rahman; Teddy Ontoseno; Budiono budiono
The Indonesian Biomedical Journal Vol 12, No 1 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i1.997

Abstract

BACKGROUND: The angiotensin-converting enzyme inhibitors (ACEIs) have become the forefront of heart failure treatment for more than a decade. Currently, angiotensin receptor blockers (ARBs) are thought to have similar effectiveness. This study aimed to compare the impact of captopril, one of ACEI, and valsartan, one of ARB, on clinical presentation and echocardiographic, electrocardiographic, and chest x-ray improvement in patients with left-to-right shunt congenitalheart diseases.METHODS: This study used a double-blind randomized controlled trial of captopril and valsatran to children with left-to-right shunt congenital heart diseases who suffer from heart failure in the Dr. Soetomo General Hospital, Surabaya, Indonesia. Pediatric heart failure scores, echocardiography, electrocardiography (ECG), and chest photographs were examined at the beginning of the study and after 30 days of treatment.RESULTS: A decrease in pediatric heart failure scores were showed after the administration of ACEI (7.06±2.04 vs. 4.75±2.43; p<0.0001; 95% CI: −2.98 - 1.65); ARB (6.81±2.25 vs. 3.94±1.98; p<0.0001; 95% CI: −3.76 to 1.98). The echocardiography examination, an increase in left ventricular end-diastolic volume (LVEDV), left ventricular ejection fraction (LVEF), % fractional shortening (FS), and left ventricular (LV) dimension occurred after the administration of ACEI and ARB. The values also didn’t significantly differrent between the two groups. The ECG evaluation showed a decrease in heart rate frequency after the administration of ACEI (117.75±14.67 vs. 109.63±17.59; p=0.039; 95% CI: −15.78 to −0.46) and ARB (117.10±21.86 vs.108.6±20.66; p=0.006; 95% CI: −14.17 to −2.83).CONCLUSION: ARB showed better outcome in clinical condition, echocardiography, ECG, and chest radiographs.KEYWORDS: captopril, valsartan, heart failure, congenital heart disease, left to right shunt 
Co-Authors Achmad Lefi Agus Harianto Alit Utamayasa Budiono budiono Chaq El Chaq Zamzam Multazam Cintya Dipta Dina Angelika Evisina Hanafiati Frans Fatchul Wahab Henry Wicaksono Heroe Soebroto I Dewa Gede Ugrasena Juliana Juliana Kartika Darma Handayani Kartika Hardiyani Martono Tri Utomo Mia Puspitasari Nabila Izzati Ni Wayan Thirthaningsih Nyilo Purnami Ovin Nada Saputri R Fatchul Wahabe Rina Elizabeth Rio Herdyanto Risa Etika, Risa Roedi Irawan Saraswati Dewi Sarmanu Sarmanu Saskia Ratna Desita Sunny Mariana Samosir Taufiq Hidayat Teddy Ontoseno Teddy Ontoseno Teddy Ontoseno Teddy Ontoseno Teddy Ontoseno Vinny Yoanna Viskasari P. Kalanjati Wiwin Retnowati Yan Efrata Sembiring Yudi Her Oktaviono, Yudi Her