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All Journal Folia Medica Indonesiana Jurnal Media Gizi Indonesia (MGI) The Indonesian Biomedical Journal Yuridika
Meity Ardiana
Departemen Kardiologi Dan Kedokteran Vaskuler Fakultas Kedokteran Universitas Airlangga/RSUD Dr. Soetomo, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Law, Crime, Criminology & Criminal Justice Public Health Other

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ENERGI, MAKRONUTRIEN, DAN CAROTID INTIMA-MEDIA THICKNESS (CIMT) PADA REMAJA OBESITAS [Energy, Macronutrients, and Carotid Intima-Media Thickness (CIMT) in Obese Adolescents] Nur Aisiyah Widjaja; Roedi Irawan; Meity Ardiana; Meta Herdiana Hanindita; Rendi Aji Prihaningtyas
Media Gizi Indonesia Vol. 15 No. 1 (2020): JURNAL MEDIA GIZI INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v15i1.22-26

Abstract

Obesity prevalence is increasing in adolescents. Subclinical chronic infl ammation in obesity causes complication, such as atherosclerosis. Cardiovascular disease is one of the complications of obesity that causes premature death. Carotid intima-media thickness (CIMT) is a subclinical marker of atherosclerosis which easily performed and noninvasive. Early detection of atherosclerosis can improved outcome. Healthy diet have a negative correlation with CIMT meanwhile high calori diet increase CIMT. This study aimed to examine the eff ect of energy and macronutrients intake on CIMT in obese adolescents. A cross sectional study was conducted on 59 adolescents aged 13-16 years old with obesity in pediatric clinic of Dr. Soetomo General Hospital using consecutive sampling method. Dietary intake was obtained through 1 x 24 hours food recall. Anthropometric measurements include body height and weight. Body Mass Index (BMI) was calculated. Obesity is defi ned as BMI higher than 95th percentile based on age and gender (CDC 2000 curve). CIMT examination was performed using B mode ultrasonography on the neck. Statistical analysis was perfomed using mutiple linear regression to analyze the eff ect of total energy, fat, and carbohydrate on CIMT. There were 59 obese adolescents included in this study, consist of 27 (45.8%) female adolescents and 32 (54.2%) male adolescents. No eff ects of total energy, carbohydrate, and fat on CIMT was found in obese adolescents (p>0.05). Further research with more subjects and at least 2x24 hours food recall are needed to assess the eff ect of calories and macronutrients on CIMT in obese adolescents.
Mortality among Heart Failure Patients in the Presence of Cachexia Andrianto; Ula Nur Pramesti Karman; Sony Wibisono Mudjanarko; Meity Ardiana; Hanestya Oky Hermawan
Folia Medica Indonesiana Vol. 59 No. 1 (2023): March
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (564.741 KB) | DOI: 10.20473/fmi.v59i1.39512

Abstract

Highlights: Around 38.8% of heart failure patients with cachexia died during the 180-1,876-day follow-up period. Cachexia increases the risk of mortality in heart failure patients. Abstract: Despite the fact that obesity has long been recognized as a risk factor for cardiovascular disease, the mortality rate of heart failure (HF) patients with cachexia is still high. Several studies have been conducted to investigate the association between cachexia and mortality in HF patients. However, the research results vary, as do the diagnostic criteria employed to assess cachexia. This meta-analysis aimed to conclusively summarize the association between cachexia and mortality in HF patients. The data were obtained from prospective or retrospective cohort studies with full texts in English or Indonesian and keywords related to "cachexia," "heart failure," and/ or "mortality". Studies that did not assess mortality in HF patients with cachexia and had no full text accessible were omitted. A literature search was conducted through four databases (PubMed, Web of Science, Scopus, and SAGE Journals) using keywords, reference searches, and/ or other methods on April 2022 in accordance with the Preferred Reported Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data from the selected studies were presented and analyzed using qualitative and quantitative synthesis methods. The Newcastle-Ottawa Scale (NOS) was used to assess the risk of bias in the selected cohort studies. The qualitative synthesis contained nine studies, whereas the quantitative synthesis (meta-analysis) included six studies. Cachexia was found in 16.0% of the 4,697 patients studied. During the 180-1,876-day follow-up period, 33.0% of the patients died, with a mortality rate of 38.8% among the patients with cachexia. The pooled analysis revealed cachexia to be a significant predictor of mortality in HF patients (hazard ratio (HR)=3.84; 95% CI=2.28-6.45; p<0.00001), but with significant heterogeneity (p<0.00001; I2=88%). In conclusion, cachexia worsens HF prognosis.
EFFECTS OF CONSUMING BISCUITS MADE FROM MORINGA OLEIFERA LEAF ON BODY WEIGHT AND HEIGHT OF CHILDREN UNDER FIVE IN BANGKALAN, MADURA ISLAND Anna Surgean Veterini; Enny Susanti; Meity Ardiana; Annis Catur Adi; Heni Rachmawati
Media Gizi Indonesia Vol. 18 No. 2 (2023): MEDIA GIZI INDONESIA (NATIONAL NUTRITION JOURNAL)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v18i2.150-156

Abstract

One of the efforts to maintain children’s nutritional status is to prevent weight faltering, which was formerly known as failure to thrive. Unresolved weight faltering will cause several problems, such as growth failure, stunting, decreased IQ, morbidity, and mortality in children. Stunting is one of the big problems that occur in Indonesia. One of the continuous strategies to prevent weight faltering is through food supplementation, such as consuming moringa leaf which is high in protein in the form of biscuits. This study aims to determine the effects of consuming biscuits made from Moringa oleifera leaf on children's growth in Bangkalan, Indonesia. This study used experimental research method for two months. The sample was drawn using consecutive sampling technique. The subjects in this study were 31 children under five whose weight and height were not according to age. Before moringa biscuits were distributed, children’s body weight and height were measured. The nutritional status was evaluated every month for two months. The parameters measured were weight gain and height increase. The results were analyzed using univariate and multivariate tests on SPSS. After giving moringa oleifera biscuits for two months at the Village Health Post (Pos Kesehatan Desa/Poskesdes) of Bangkalan, children’s body weight increased by 0.35 kg per month and their height increased by 0.65 cm per month. The distribution of biscuits can be continued to preventing stunting.
Corporate Criminal Liability in Procurement of Goods and Services in Hospital Meity Ardiana; Adriano Adriano; Kurniadi Doni; Yulianto Yulianto
Yuridika Vol. 38 No. 2 (2023): Volume 38 No 2 May 2023
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ydk.v38i2.43674

Abstract

Procurement of goods and services for the benefit of the government is one of the tools to drive the wheels of economy in order to improve the national economy in order to create people's welfare and improve the quality of human resources. However, there are many problems in the implementation of the goods and services procurement program, such as mark-ups that exceeded the limit and law enforcement which was considered problematic, this resulted in the difficulty of determining which administrators were responsible for violations in the procurement of goods and services, given the complex form of management in a corporation that raises doubts about the possibility of the corporation to be held criminally liable and sentenced. Especially in hospitals which, at every level, every subject who carries out their duties and functions, can represent the hospital as a corporation. This article discusses corporate criminal responsibility for violations committed by Directors, Budget User Authorities, procurement committees and/or project executors in the procurement of goods and services in hospitals. This study will answer how is the criminal responsibility for violations committed by the Director and Committee in the procurement of goods and services at the Hospital and how is corporate criminal responsibility towards third parties for violations committed in the procurement of goods and services at the Hospital. The method used is qualitative and the approaches used are statute, conceptual, and case.
Losartan Has a Comparable Effect to Human Recombinant ACE2 in Reducing Interleukin-6 (IL-6) Levels on Human Adipocytes Exposed to SARS-CoV-2 Spike Protein Hanestya Oky Hermawan; Meity Ardiana; I Gde Rurus Suryawan; Primasitha Maharany Harsoyo; Muhammad Rafli
The Indonesian Biomedical Journal Vol 15, No 5 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i5.2552

Abstract

BACKGROUND: High angiotensin-converting enzyme 2 (ACE2) expression in adipocyte cells facilitates the initiation of SARS-CoV-2 infection and triggers a cytokine storm. This finding suggests that obesity is an independent risk factor for the severity of the symptoms caused by COVID-19. The use of cardiovascular medications that focus on ACE2, such as angiotensin II receptor blockers, remains controversial, and their effects on inflammatory cytokine production and ACE2 expression in cells, especially adipocytes, remain inconsistent.METHODS: The human adipocytes were isolated from obese donor subcutaneous adipose tissue and infected with the subunit S1 spike protein from SARS-Cov-2. The adipocytes were later treated with either hrsACE2 or losartan. The levels of ACE2 and inflammatory cytokines interleukin (IL)-6, IL-1β, and tumor necrosis factor (TNF)-α were measured using enzyme linked immunosorbent assay (ELISA). ACE2 and S1 spike protein binding assays were also performed. RESULTS: ACE2, IL-6, and TNF-α levels were significantly increased in human adipocyte cells infected with SARS-Cov-2 but not IL-1β. There was a statistically significant positive correlation between ACE2 and IL-6 (r=0.878, p<0.001). Administration of losartan and hrsACE2 was shown to reduce ACE2 levels and its binding to the SARS-CoV-2 S1 spike protein, and IL-6 levels were statistically significant, but had no significant effect on IL-1β or TNF-α levels.CONCLUSION: This study shows that the administration of losartan in COVID-19 may not be harmful, but instead has a protective effect similar to that of hrsACE2 in preventing a cytokine storm, especially IL-6.KEYWORDS: obesity, SARS-CoV-2, losartan, IL-6, ACE2
Co-Authors Adriano Andrianto Anna Surgean Veterini Annis Catur Adi Enny Susanti Hanestya Oky Hermawan Hanestya Oky Hermawan Heni Rachmawati I Gde Rurus Suryawan Kurniadi Doni Meta Herdiana Hanindita Muhammad Rafli Nur Aisiyah Widjaja Primasitha Maharany Harsoyo Rendi Aji Prihaningtyas Roedi Irawan Sony Wibisono Mudjanarko Ula Nur Pramesti Karman Yulianto Yulianto