Article Per Year (5 Year)
p-Index From 2019 - 2024
0.444
P-Index
This Author published in this journals
All Journal Majalah Obat Tradisional Majalah Farmaseutik
Woro Rukmi Pratiwi
Departement Pharmacology and Therapy, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada
Health Professions Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Effects of Poly-herbal Tablet as Herbal Medicine on Lipid Level Woro Rukmi Pratiwi; Eti Nurwening Sholikhah; Dwi Aris Agung Nugrahaningsih; Mia Munawaroh Yuniyanti; Mustofa Mustofa; Ngatidjan Ngatidjan
Majalah Obat Tradisional Vol 24, No 1 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (210.299 KB) | DOI: 10.22146/mot.43108

Abstract

Dyslipidemia is one of the high-risk factors that cause cardiovascular disease and the prevalence is increasing all the time. Garlic (Alii sativi) has been suggested to reduce serum lipid level. Poly-herbal is herbal medicine that has been widely used in Indonesia, and it contains Alii sativi, Belericae fructus, Curcumae aeroginosae, and Amomi fructus extract. This study aimed to evaluate the effects of poly-herbal tablet on lipid levels in dylipidemia subjects. The study was conducted for 6 weeks on 58 dyslipidemic subjects. The subject was divided into 2 groups. Group 1 was given Poly-herbal with the dose 2x1200 mg, and group 2 was not given anti-dyslipidemic drugs (control group). Serum lipid level (total cholesterol, LDL, HDL, and triglycerides) were checked before the treatment (H0) and after the treatment (M6). There was a significant difference on the reduction of serum lipids level between the group that given Poly-herbal vs control group, respectively total cholesterol (-12.04±3.2 vs 8.38±4.3; p=.000),  LDL (-4.42±2.8 vs 6.93±4.7; p=.049) and HDL (-2.62+1.0 vs 3.31+1.4; p=.005). Triglyceride level on Poly-herbal group is not significantly decreased. In Poly-herbal group there was also a decrease in HDL levels which was not statistically significant (-2.62±1, p=.015). This is probably due to the HDL baseline in the control group included in the normal HDL category (57.38 ± 14.9) so that the HDL levels after being given treatment did not increase. This study suggests that using Poly-herbal in dyslipidemia subjects can reduce the level of total cholesterol and LDL.
Acute Oral Toxicity Test of Antihypertensive Polyherbal Preparations Containing Allium sativum Curcuma aeruginosa & Amomi fructus Herzan Marjawan; Woro Rukmi Pratiwi; Dwi Aris Agung Nugrahaningsih; Eti Nurwening Sholikhah; Pamungkas Bagus Satriyo
Majalah Farmaseutik Vol 18, No 4 (2022): in press
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v18i4.79299

Abstract

Hypertension is a major factor causing atherosclerotic cardiovascular disease, heart failure, stroke, and kidney failure. Polyherbal preparations containing garlic (Aliium sativum), temu ireng (Curcumae aeruginosae) and cardamom (Amomi fructus) have been widely used to treat hypertension. Despite widely used in community, its safety has not been evaluated. This study aimed to evaluate the single dose oral safety of the polyherbal. The acute oral toxicity test was done using fixed dose methods. Single dose of the polyherbal was administered to female Wistar rats. The clinical examination was done after administration of the polyherbal and continued until the 14th day to check for symptoms of toxicity, changes in body weight. On day 15, the animal was sacrificed and histopathological examination was conducted. The body weight did not differ between animal that received polyherbal and not received polyherbal. However, there was an increase in body weight in a group that received polyherbal at a dose of 2000 mg/kg. The absolute and relative organs weight was also similar among groups. There were no macroscopic and histopathological changes in kidney, liver, heart, spleen, aorta, and lungs. The polyherbal preparations containing Aliium sativum, Curcumae aeruginosae and Amomi fructus is safe with LD50 >2000-5000 mg/kg in Wistar rats.
Co-Authors Dwi Aris Agung Nugrahaningsih Eti Nurwening Sholikhah Eti Nurwening Sholikhah Herzan Marjawan Mustofa Mustofa Ngatidjan Ngatidjan Nugrahaningsih, Dwi Aris Agung Pamungkas Bagus Satriyo Yuniyanti, Mia Munawaroh