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All Journal INDONESIAN JOURNAL OF PHARMACY
Daryono H. Tjahjono
School of Pharmacy, Institute of Technology Bandung, Jl. Ganesha 10 Bandung 40132, Indonesia
Medicine & Pharmacology

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PHOTOPHYSICAL AND PHYSICOCHEMICAL PROPERTIES OF Cu(II)CHLORIN e4 AND Cu(II)CHLORIN e6 AS A LEAD COMPOUND OF PHOTOSENSITIZER FOR PDT Eva Susanty Simaremare; Asmiyenti D. Djalil; Daryono H. Tjahjono
Indonesian Journal of Pharmacy Vol 26 No 1, 2015
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (843.458 KB) | DOI: 10.14499/indonesianjpharm26iss1pp29

Abstract

Porphyrin derivatives are potential compounds for diagnostic agent and photosensitizer in photodynamic therapy. However, they have a weakness in molar absorptivity, especially in visible region of Q band which used to excite them. Due to incapabilities of porphyrin, other tetrapyrole derivatives, such as chlorophyllin can be alternative for a lead compound of photosensitizer. In the present research, two chlorin derivatives were isolated from commercial chlorophyllin product. Their photophysical and physicochemical properties, i.e. molar absorptivity, quantum yield of fluorescence and quantum yield of singlet oxygen were determined. Chlorophyllin carboxylic acid form, Cu(II)-chlorin e4 and Cu(II)-chlorin e6,were successfully isolated with recovery of 11.33% and 16.46%, respectively.         The absorption spectrum of Cu(II)-chlorin e4 showed an intense Soret band at 406 nm and two weaker Q bands at 628nm, 658nm. Fluorescence efficiency was 0.09 while efficiency for singlet oxygen at  pH 6.3 and 7.4 were 0.0052±0.0017 and 0.0066±0.0012. Cu(II)-chlorin e6 displayed soret band at 407nm and Q bands at 627nm, 663nm. Singlet oxygen at pH 6.3 was 0.0029±0.0007, while at pH 7.4 was 0.0034±0.0001. However,  Cu(II)-chlorin e6 did not show fluorescence.Key words: Chlorophyllin, Cu(II)-chlorin e4, Cu(II)-chlorin e6, singlet oxygen fluorescence
Co-Authors Asmiyenti D. Djalil Eva Susanty Simaremare