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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Ilmu Dasar Jurnal Ners Indonesia
M Rasjad Indra
Medical Faculty, Brawijaya University, Malang - Indonesia
Agriculture, Biological Sciences & Forestry Control & Systems Engineering Dentistry Environmental Science Health Professions Mathematics Nursing Public Health Veterinary

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FAKTOR PERAWAT YANG BERHUBUNGAN DENGAN ANGKA READMISSION PADA PELAKSANAAN DISCHARGE PLANNING PASIEN ACUTE CORONARY SYNDROME (ACS) DI RSUD DR. SAIFUL ANWAR MALANG Romalina Romalina; M Rasjad Indra; Dian Susmarini
Jurnal Ners Indonesia Vol 6, No 1 (2016)
Publisher : Fakultas Keperawatan, Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (309.077 KB) | DOI: 10.31258/jni.6.1.40-44

Abstract

Acute coronary syndrome (ACS) menjadi masalah masyarakat kesehatan secara global baik di negaramaju atau berkembang.Sistem Informasi Rumah Sakit (SIRS) (2010-2011) menunjukkan bahwa penyakitjantung merupakan penyebab terbesar rawat inap. Penanganan awal pasien ACSseharusnya dilakukan sejakserangan terjadi, kemudian dilanjutkan penanganan di rumah sakit.Tidak adekuatnya discharge planningmenyebabkan pasiendirawatkembali di ruanggawatdarurat. Faktor-faktor yang mempengaruhi dischargeplanning, antara lain : faktor pasien, perawatdanmanajemen . Tujuan dalam penelitian ini untuk mengetahuifaktor perawat yang berhubungan dengan angka readmission pada pelaksanaan discharge planning pasien ACSdi RSUD Dr. Saiful Anwar Malang.Rancangan dalam penelitian ini adalah analitik observasional denganpendekatan prospektif. Penelitian dilaksanakan pada Agustus-Oktober 2014 di RSUD Dr. Saiful Anwar Malang.Sampel berjumlah 60 orang perawat pendekatan consecutive sampling. Pengumpulan data menggunakankuesioner dan lembar observasi.Analisa datamultivariatmenggunakanregresilogistikdenganmetodebackward.Hasil analisis multivariat menunjukkan bahwa edukasi pasien (RR 0,063) berpengaruh terhadap angkareadmission pasienACS. Kesimpulanfaktor beban kerja perawat meningkatkan angka readmission pasienACS.Faktor edukasi pasien menurunkan angka readmission pasien ACS. Faktor prediktor angka readmissionpasien ACSadalah edukasi pasien.
The Role Of Lycopene to Nuclear Factor Kappa Beta (Nf-κB) Activities and Intracellular Cell Adhesion Molecule-1 (Icam-1) Expressions on Leptin-Induced Endothelial Cell Heni Fatmawati; S Satuman; Endang SW; A Rudijanto; M Rasjad Indra
Jurnal ILMU DASAR Vol 11 No 2 (2010)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (299.881 KB)

Abstract

There is adipocytokine dysregulation on obesity such as amplified leptin, and reduced adiponectin at serum levels . Leptin has been proved to increase oxidative stress in endothelial cell. The adipocyte functions as an important secretory organ via nuclear factor-κ B (NF-κB) releasing a number of bioactive molecules such as leptin. Lycopene, an antioxidant, is presumed having the ability to block the atherogenesis mechanism, which is stimulated a proinflamatory cytokine and adhesion molecules ICAM-1 by NF-κB. Therefore, the aim of this research was to prove and to determine whether lycopene could decrease the NF-κBandICAM-1 expressionin Human Umbillical Vein Endothelial Cells (HUVECs) culture induced by 500 ng/mL leptin. In vitro study used primary culture of the HUVECs were devided in to 7 groups, there were (1) 0 ng/mL leptin and 0 μM lycopene, (2) induced by 500 ng/mL leptin for 12 hours, (3) induced by leptin and lycopene with concentration 10; 25; 40; 55 and 75 μM for 12 hours. Then the identification of NF-κB was applied by using imunocytochemistry compared with ELISA procedure on cell endothel culture lysate and ICAM-1 expression was measured by using RT PCR. It was showed that lycopene 25 μM decreased NF-κB level and ICAM-1 expression significantly in Human Umbillical Vein Endothelial Cells (HUVECs) culture induced by leptin 500 ng/mL.Leptin was increased NF-κB and ICAM-1 expression in HUVECs culture and was decreased by lycopene. Optimum dose of lycopene is 25 μM.
Binding Inhibition Between Igf1r and Igf1 by Catechin of Black Tea Lina Firdausi; M Rasjad Indra; fatchiyah .
Journal of Tropical Life Science Vol. 2 No. 3 (2012)
Publisher : Journal of Tropical Life Science

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Abstract

The natural compound of black tea is used as an alternative of obesity therapies in the world; particularly, the catechin family in tea leaves which has bioactive compounds such as EC, EGC and EGCG. Their bioactivity contributes to inhibit the ligand of Insulin-Like Growth Factor I Receptor (Igf-1r) binding-region to Igf-1 protein. To elucidate the inhibiton of Igf-1 expression and proliferating of Rattus norvegicus strain wistar adipose cell using black tea solution. The research used Rattus norvegicus strain wistar. After a 90-day treatment, the adipose tissues were picked up from the viscera of each experimental animal, and then the adipose tissues were embedded by paraffin. The paraffin sections were determined through immunohistochemistry with anti-Igf-1 antiserum, and were also analyzed through hematoxylin-eosin. A protein sequence of Igf-1, Igf-1r, and 3D structure of EC, EGC and EGCG from Gene Bank sites were used during in silico analysis. The sequences were aligned by BLAST program to identify the conserve and variable domain of IGF-1 protein isoforms. The 3D structures of IGF-1 and IGF-1R were constructed using Phyre program. The ligand among the 3D structures of IGF-1, IGF-1R and catechin compounds were analyzed using Hex 5.1 docking program. The data showed that the Igf-1 expression of adipose cells was reduced at 0,03 g/ml BTS and 0,045 g/ml BTS treatments. The result of BLAST analysis showed that IGF-1 (a, b, c, and d) isoforms conserved a domain from amino acid no 22 until 134; and this region was a variable region. The EGCG bound L1 domain of IGF-1R with E-total -235.3 KJ/mol which was lower than EC (-208,4 KJ/mol) and EGC (-142 KJ/mol). The total energy of IGF-1 (a, b, c, but not d isoform) which interacted with EGCG was around -223.7 KJ/mol, EC is -205.6 KJ/mol and EGC was -191.7 KJ/mol. However, EC, EGC and EGCG was only able to prevent the interaction between the L1 of IGF-1R with IGF-1 protein, but not the opposite.Keywords: Adipose cell, black-tea, proliferation, catechin, IGF-1, IGF-1R, inhibition, docking
Co-Authors A Rudijanto Dian Susmarini Endang SW fatchiyah . Heni Fatmawati Lina Firdausi Romalina, Romalina S Satuman