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Wafi Banadzir Resya
Dept of Medicine, Faculty of Medicine, Diponegoro University Semarang
Medicine & Pharmacology

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DIFFERENCES IN INTERLEUKIN-23 SERUM LEVELS TOWARDS THE SEVERITY OF ACNE VULGARIS IN WOMEN Wafi Banadzir Resya; Novi Kusumaningrum; Santoso Jaeri; Astika Widy Utomo
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 4 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i4.30029

Abstract

Background: Acne vulgaris is a chronic inflammatory disease in the pilosebaceous gland of the skin which can cause depression and anxiety. IL-23 is a cytokine that is involved in autoimmune diseases, including acne vulgaris. IL-23 affects the differentiation process of Th17 which further produces IL-17, an important component in the pathogenesis of acne vulgaris. IL-17 plays a significant role in the grade of skin damage caused by the inflammation process.Objective: To find out differences in IL-23 serum levels and the grade of AV severity in women.Methods: An observational study with a cross-sectional design approach conducted from June until October 2020 in 15 women with AV aged 15-25 years old, not consuming anti-inflammatory drugs, antibiotics, retinoid group of drugs and free from other inflammatory diseases. Subjects were divided into three groups based on the AV severity grade: specifically mild (n=5), moderate (n=5) and severe (n=5). Subjects had venous blood taken for IL-23 serum content by the ELISA method. Data on IL-23 serum content in the three groups were tested using the One-Way ANOVA method to determine the differenceResults: Average age from the 3 groups was 21 (17-23 ) years old. The results showed that there is no significant difference in IL-23 rate from the 3 groups of AV severities (p=0,490).Conclusion: : There is no significant difference of IP-23 rate between the 3 groups of AV severites in women. 
Co-Authors Astika Widy Utomo, Astika Widy Novi Kusumaningrum Santoso Jaeri