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All Journal Jurnal Kedokteran Diponegoro Ophthalmologica Indonesiana
Andreas Tigor Partomuan
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Health Professions Medicine & Pharmacology Public Health

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PENGARUH EKSTRAK GYNURA DIVARICATA TERHADAP KADAR MDA DARAH TIKUS TERINDUKSI KANKER PAYUDARA Andreas Tigor Partomuan; Innawati Jusup
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 5, No 4 (2016): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (387.104 KB) | DOI: 10.14710/dmj.v5i4.14237

Abstract

Latar Belakang : Kanker payudara merupakan penyakit keganasan dengan angka kasus sebesar 43,2% dan angka kematian 12,9% diantara penyakit keganasan lainnya pada tahun 2012. MDA merupakan salah satu marker biokimia yang dapat digunakan untuk penilaian profil kanker. Beberapa tahun terakhir terapi herbal bagi penyakit kanker banyak diteliti, salah satunya Gynura divaricata.Tujuan : Mengetahui pengaruh ekstrak daun Gynura divaricata terhadap kadar MDA darah tikus terinduksi kanker payudara.Metode : Penelitian eksperimental ini menggunakan rancangan post-test only control group design. 15 ekor tikus betina Sprague Dawley® dibagi 3 kelompok secara acak, yaitu selama 3 bulan, masing-masing kelompok kontrol negatif (K1) diberi diet standar, kelompok kontrol positif (K2) diberi pakan standar dan diinduksi kanker payudara, serta kelompok perlakuan (P) yang diberi pakan standar, kemudian diinduksi kanker payudara, lalu diberikan ekstrak Gynura divaricata dengan dosis 750 mg/kgBB setiap hari. Pada hari ke-15, darah dari masing-masing kelompok diambil untuk diteliti kadar MDA di dalamnya. Setelah itu, hasil penelitian diuji hubungannya secara statistik menggunakan metode one way ANOVAHasil : Rerata kadar MDA darah yang didapatkan adalah 2,671(K1), 4,088(K2), dan 3,233(P). Kadar MDA darah pada ketiga kelompok dianalisis menggunakan uji one way ANOVA dan mendapatkan hasil p=0,330.Kesimpulan : Terdapat pengaruh yang dari ekstrak Gynura divaricata terhadap kadar MDA darah tikus terinduksi kanker payudara. Namun, perbedaan yang didapatkan tidak signifikan.
TWO YEARS DESCRIPTIVE STUDY OF MACULAR HOLE PATIENTS OPERATED IN DR. KARIADI GENERAL HOSPITAL, SEMARANG Andreas Tigor Partomuan; Arief Wildan
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/8d6phz88

Abstract

Introduction & ObjectivesMacular hole (MH) is a vitreomacular interface disorder that could cause visual impairment. Clinicalcharacteristics of MH are important for predicting MH treatment outcomes. This study purpose wasto describe MH patients’ characteristics and postoperative outcomes in Dr. Kariadi Hospital. MethodsA retrospective study held on January 2021–December 2022 utilizing patients’ medical records.Preoperative data: sex, age, symptoms, duration of symptoms, origin, preoperative visual acuity(VA), modified Gass classification stage, macular hole index (MHI), and hole forming factor (HFF)were obtained. Postoperative outcomes data: postoperative VA and anatomical closure were alsocollected. Results20(20 eyes) patients were obtained, with 14(70%) female, 12(60%) aged >60 years old, 13(65%)metamorphopsia, 12(60%) central visual loss, 10(50%) preoperative VA 6/24-6/60, 10(50%) durationof symptoms <3 months, and 16(80%) idiopathic origin. OCT (Ocular Coherence Tomography)findings revealed base diameter mean was 780,7 um(+ SD 312). 13 patients (65%) stage 3 of MH,12(60%) MHI <0,5, 12(60%) HFF > 0,9. All patients underwent MH surgery procedures.Postoperative examination showed 10 patients(50%) with VA 6/6-6/20. 11(100%) with preoperativeVA>6/60, 10(100%) with duration of symptoms <3 months, 8(100%) with MHI > 0,5, and 11(100%)with HFF > 0,9 had improved visual acuity and anatomical closure. It also revealed 17(85%) hadanatomical closure. ConclusionThe most common characteristics found in MH patients were female sex, age >60 years old, anddisorder of idiopathic origin. Preoperative VA, duration of symptoms <3 months before surgery, MHI> 0,5, and HFF > 0,9 were positive prognostic factors for better postoperative functional andanatomical outcomes.
Co-Authors Arief Wildan Innawati Jusup