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All Journal Dentino: Jurnal Kedokteran Gigi Dentin
Fransiska Uli Arta Panjaitan
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Dentistry

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THE EFFECT OF HYDOXYAPATITE XENOGRAFT OF HARUAN FISH (Channa striata) BONE ON THE NUMBER OF OSTEOBLAST AND OSTEOCLAST (In Vivo Study On Mandibular Bone of Male Guinea Pigs) Novia Agustina; Irnamanda DH; Fransiska Uli Arta Panjaitan
Dentino : Jurnal Kedokteran Gigi Vol 3, No 2 (2018)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v3i2.5364

Abstract

Background: Periodontitis is an inflammation of the periodontium tissue caused by certain microorganisms. The condition it self is marked by alveolar bone damage. The repair of damaged alveolar bone requires a process of bone remodeling. To help the process of bone remodeling, a graft material from haruan fish bone is used. The haruan fish bone is a waste from industrial processing crackers that have not been used by the people of South Kalimantan. The fish bone has inorganic substances such as calcium and phosphate. Objective: To prove the effect of xenograft hydroxyapatite of haruan fish bone on the number of osteoblast and osteoclast in remodeling process of male marmot bone. Methods and materials: This study used a pure experimental study with posttest only control group design. This study used two treatment groups which were the treatment group using hydroxyapatite haruan fish bone and a negative control group using aquades. Results: The mean value of osteoblast cell number after given hydroxyapatite of haruan fish bone was 15,72 cells, which was higher than given aquades only with 5,08 cells. While the number of osteoclast after given hydroxyapatite of haruan fish bone was 6,72 cells. It was higher than the given aquades only group which results in 4,04 cells. The Independent T test showed a significant difference (p<0.05) between the hydroxyapatite of haruan fish bone group and the negative control group with osteoblast data where p = 0,000 and osteoclast data where p = 0,006. Conclusion: Giving hydroxyapatite ofharuan fish bone can increase the number of osteoblast and osteoclasts in the remodeling process of male marmot bone.
ANTIBACTERIAL EFFECTIVITY OF FLAVONOID FRACTION OF RAMANIA LEAF EXTRACT (Bouea macrophylla Griffith) AGAINST Porphyromonas gingivalis Lailatul Qomariyah; Fransiska Uli Arta Panjaitan; Rosihan Adhani
Dentino : Jurnal Kedokteran Gigi Vol 6, No 1 (2021)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v6i1.10644

Abstract

ABSTRACTBackground: Chronic periodontitis is a periodontal disease with 80% of all cases of periodontitis. The major causes are the accumulation of plaque and bacteria. The dominant bacteria in chronic periodontitis is Porphyromonas gingivalis. Treatment of chronic periodontitis can be done by scaling and root planing and supporting therapy by using mouthwash such as Chlorhexidine gluconate 0.2% which is the gold standard in the treatment of periodontal disease. Chlorhexidine gluconate 0.2% has disadvantages so that nowadays research on herbal plants is being done to find alternative medicines that are more effective. Ramania (Bouea machropylla Griffith) leaf contains flavonoids that have antibacterial properties. Objective: To analyze the antibacterial effectivity of the flavonoid fraction of Ramania leaf extract against Porphyromonas gingivalis that causes chronic periodontitis. Method: True experimental study and post-test with control group design consisting of 5 treatment groups, namely flavonoid fraction of ramania leaf extract with concentrations of 0.1%, 0.3%, and 0.5%, chlorhexidine gluconate 0.2% as a control positive and aquadest as a negative control. Each group was repeated 6 times. Antibacterial tests using the dilution method with inhibitory rates calculated using a UV-Vis spectrophotometer and killing rates were calculated using a Colony Counter. Results: The average difference in absorbance values obtained inhibitory rates at concentrations of 0.1%, 0.3%, and 0.5%. One Way Anova Test showed a significance value of 0,000 (p < 0.05). The average number of colonies after 24 hours incubation showed the results of a kill rates in the concentration group of 0.3%, 0.5%, and positive control. The Kruskal Wallis test showed a significance value of 0,000 (p < 0.05). Conclusion: The minimum inhibitory concentration (MIC) was obtained at a concentration of 0.1% and the minimum bactericidal concentration (MBC) was obtained at 0.3% concentration.Keywords: Flavonoid Fraction, MBC, MIC, Porphyromonas Gingivalis, Ramania Leaf Extract.
BIOCOMPABILITY TEST OF HARUAN FISH (Channa striata) BONE HYDROXYAPATITE TO FIBROBLAST CELL AS PERIODONTAL POCKET THERAPY (In Vitro Study on BHK-21 Fibroblast Cell with Hydroxyapatite of Haruan Fish Bone (Channa striata) as Bone Graft Material) Maulidah Maulidah; Irnamanda DH; Fransiska Uli Arta Panjaitan
Dentino : Jurnal Kedokteran Gigi Vol 3, No 2 (2018)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v3i2.5370

Abstract

Background: Periodontitis is an inflammation of the soft tissues and hard tissues that support the tooth characterized by periodontal pocket formation, recession to resorption of alveolar bone. So far, alveolar bone resorption caused by periodontitis can be treated with bone graft therapy. Xenograft is a type of bone graft that has many advantages such as can be obtained from natural materials, low in price and has minimal virus transmission. Hydroxyapatite of haruan fish bone is a type of xenograft material that has never been applied in medical field. Objective: This study aims to analyze the biocompatibility of haruan fish bone hydroxyapatite (Channa striata) against BHK-21 fibroblast cells via viability. Method: This was a laboratory experimental study with posttest only control group design, using MTT assay method and BHK-21 fibroblast cell viability was calculated using optical density formula. Results: The concentrations of 0,2109 mg/ml, 0,4218 mg/ml 0,8437 mg/ml, 1,6875 mg/ml, 3,3375 mg/ml and 6,75 mg/ml were biocompatible against fibroblast cells BHK-21 whereas at concentrations of 54 mg/ml, 27 mg/ml and 13,5 mg/ml were toxic to BHK-21 fibroblast cells. One Way Anova test and Bonferroni test showed concentrations of 54 mg/ml, 27 mg/ml and 13,5 mg/ml had significant differences to other concentrations. Conclusion: Hydroxyapatite of haruan fish bone (Channa striata) at some concentration is biocompatible against BHK-21 fibroblast cells.
ANTIBACTERIAL EFFECTIVITY OF FLAVONOID FRACTION OF RAMANIA LEAF EXTRACT (Bouea macrophylla Griffith) AGAINST Porphyromonas gingivalis Lailatul Qomariyah; Fransiska Uli Arta Panjaitan; Rosihan Adhani
Dentino : Jurnal Kedokteran Gigi Vol 6, No 2 (2021)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v6i2.11997

Abstract

Background: Chronic periodontitis is a periodontal disease with 80% of all cases of periodontitis. The major causes are the accumulation of plaque and bacteria. The dominant bacteria in chronic periodontitis is Porphyromonas gingivalis. Treatment of chronic periodontitis can be done by scaling and root planing and supporting therapy by using mouthwash such as Chlorhexidine gluconate 0.2% which is the gold standard in the treatment of periodontal disease. Chlorhexidine gluconate 0.2% has disadvantages so that nowadays research on herbal plants is being done to find alternative medicines that are more effective. Ramania (Bouea machropylla Griffith) leaf contains flavonoids that have antibacterial properties. Objective: To analyze the antibacterial effectivity of the flavonoid fraction of Ramania leaf extract against Porphyromonas gingivalis that causes chronic periodontitis. Method: True experimental study and post-test with control group design consisting of 5 treatment groups, namely flavonoid fraction of ramania leaf extract with concentrations of 0.1%, 0.3%, and 0.5%, chlorhexidine gluconate 0.2% as a control positive and aquadest as a negative control. Each group was repeated 6 times. Antibacterial tests using the dilution method with inhibitory rates calculated using a UV-Vis spectrophotometer and killing rates were calculated using a Colony Counter. Results: The average difference in absorbance values obtained inhibitory rates at concentrations of 0.1%, 0.3%, and 0.5%. One Way Anova Test showed a significance value of 0,000 (p < 0.05). The average number of colonies after 24 hours incubation showed the results of a kill rates in the concentration group of 0.3%, 0.5%, and positive control. The Kruskal Wallis test showed a significance value of 0,000 (p < 0.05). Conclusion: The minimum inhibitory concentration (MIC) was obtained at a concentration of 0.1% and the minimum bactericidal concentration (MBC) was obtained at 0.3% concentration. Keywords: Flavonoid Fraction, MIC, MBC, Porphyromonas Gingivalis, Ramania Leaf Extract.
EFEKTIVITAS ANTIBAKTERI EKSTRAK DAUN BINJAI (Mangifera caesia) TERHADAP PERTUMBUHAN BAKTERI Porphyromonas gingivalis (Studi in vitro dengan Metode Dilusi) Nisa Fachrizha Munier; Fransiska Uli Arta Panjaitan; Juliyatin Putri Utami
Dentin Vol 5, No 2 (2021)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACTBackground: Porphyromonas gingivalis is one of bacteria colonizes in subgingivai. This causes of periodontitis. Porphyromonas gingivalis have secretes some compounds can damage periodontal tissue. Chlorhexidine gluconate 0.2% is used as periodontitis treatment, but using long-term can cause side effects. Natural-based medicinal utilizing is considered safe because it has fewer side effects than modern medicine. One of potential plant is Binjai (Mangifera caesia) which has active compounds such as flavonoid, saponin and tannin. These have optimal functions as antibacterial. Purpose: To determined and compared the antibacterial effectiveness of Binjai leaf extract on the growth of Porphyromonas gingivalis bacteria with concentrations of 50%, 80% and 95%. Method: True experimental design of post test only with control group design used 5 treatments: three groups of Binjai leaf extract and two groups of control: positive control and negative control which were repeated 5 times. Measurement of Minimum Inhibitory Concentration (MIC) was calculated using an Uv-Vis Spectrophotometer and measurement of the Minimum Bactericidal Concentration (MBC) was calculated using a colony counter. Result: MIC was obtained at a concentration of 50% and MBC was obtained at a concentration of 80%. Conclusion: The Binjai leaf extract has antibacterial effectiveness against the growth of Porphyromonas gingivalis. Keywords: Antibacterial, Binjai Leaf Extract, MBC, MIC, Porphyromonas gingivalis  ABSTRAKLatar Belakang: Kolonisasi bakteri pada subgingiva yang menyebabkan periodontitis salah satunya adalah Porphyromonas gingivalis. Porphyromonas gingivalis mengeluarkan beberapa senyawa yang dapat merusak jaringan periodontal. Chlorhexidine gluconate 0,2% sering digunakan dalam terapi periodontitis, tetapi penggunaan jangka panjang dapat menimbulkan efek samping. Penggunaan obat berbahan dasar alami dinilai aman karena memiliki efek samping lebih sedikit daripada obat modern, salah satu tanaman berpotensi adalah Mangifera caesia yang memiliki senyawa aktif seperti flavonoid, saponin dan tanin yang memiliki fungsi optimal sebagai antibakteri. Tujuan: Mengetahui dan membandingkan efektivitas antibakteri ekstrak daun binjai (Mangifera caesia) terhadap pertumbuhan bakteri Porphyromonas gingivalis konsentrasi 50%, 80% dan 95%. Metode: True experimental design dengan post test only with control group design menggunakan 5 kelompok perlakuan yaitu 3 kelompok ekstrak daun binjai serta dua kelompok kontrol yaitu kelompok positif dan negatif dengan 5 kali pengulangan. Pengukuran Konsentrasi Hambat Minimum (KHM) dilakukan menggunakan alat Spektrofotometer Uv-Vis dan pengukuran Konsentrasi Bunuh Minimum (KBM) dilakukan menggunakan colony counter. Hasil: KHM didapatkan pada konsentrasi 50% dan KBM didapatkan pada konsentrasi 80%. Kesimpulan: Ekstrak daun binjai (Mangifera caesia) memiliki efektivitas antibakteri terhadap pertumbuhan Porphyromonas gingivalis. Kata Kunci: Antibakteri, Ekstrak Daun Binjai, KBM, KHM, Porphyromonas gingivalis
COMPARISON OF KELAKAI AND KATUK EXTRACT COMBINATION TO 0.2% CHLORHEXIDINE GLUCONATE AGAINST Porphyromonas gingivalis Erisa Lidiya; I Wayan Arya Krishnawan Firdaus; Fransiska Uli Arta Panjaitan
Dentin Vol 7, No 2 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentin.v7i2.9722

Abstract

Background: Periodontal disease is the second most frequent oral disease in Indonesia, which includes periodontitis. Porphyromonas gingivalis is the predominant bacteria in chronic periodontitis. This disease is usually treated with 0.2% chlorhexidine gluconate mouthwash. However, 0.2% chlorhexidine gluconate has several adverse effects, such as tooth discoloration, irritation of the oral mucosa, and changes in taste sensation. Therefore, an herbal-based mouthwash is needed. A combination of kelakai leaf and katuk leaf extract contains antibacterial substances such as flavonoid, tannin, steroid, alkaloid, and saponin, which can be used as an alternative therapy for chronic periodontitis. Purpose: To compare the inhibitory zone of kelakai and katuk extract combination with 0.2 Chlorhexidine gluconate against Porphyromonas gingivalis. Method: True experimental design with 13 treatment groups and 3 repetitions for each group. The treatment groups include combinations of kelakai leaf extract with 25%, 50%, 75%, 100% concentrations and katuk leaf extract with 20%, 40%, 80% concentrations and 0.2% chlorhexidine gluconate, which were tested on Porphyromonas gingivalis with a total of 39 samples. The inhibitory zone is measured with caliper after incubated for 48 hours.  Results: One-Way ANOVA revealed significant differences between all treatment groups and 0.2% chlorhexidine gluconate. Consequently, the Bonferroni post-hoc test was performed, which showed that the antibacterial activity of 75% kelakai leaf and 80% katuk leaf extract did not differ significantly from the activity of 0.2% chlorhexidine gluconate. Conclusion: The combination of 75% kelakai leaf and 80% katuk leaf extract has an equal antibacterial activity to 0.2% chlorhexidine gluconate against Porphyromonas gingivalis statistically. Keywords : 0.2 % Chlorhexidine gluconate, chronic periodontitis, combination of kelakai and katuk leaf extract, inhibitory activity, Porphyromonas gingivalis
Co-Authors Erisa Lidiya I Wayan Arya Krishnawan Firdaus Irnamanda DH Lailatul Qomariyah Maulidah Maulidah Nisa Fachrizha Munier Novia Agustina Rosihan Adhani, Rosihan Utami, Juliyatin Putri