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All Journal ODONTO Dental Journal Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Dentino: Jurnal Kedokteran Gigi Padjadjaran Journal of Dentistry Molecular and Cellular Biomedical Sciences (MCBS) Dentin Bubungan Tinggi: Jurnal Pengabdian Masyarakat Jurnal Pengabdian Ilung (Inovasi Lahan Basah Unggul) Jurnal Pengabdian Sumber Daya Manusia Denta: Jurnal Kedokteran Gigi Makara Journal of Science Odonto dental journal
Utami, Juliyatin Putri
Departemen Biomedik, Fakultas Kedokteran Gigi, Universitas Lambung Mangkurat
Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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STUDY ANALYSIS OF ORAL TUBERCULOSIS LESION IN SOUTH KALIMANTAN, INDONESIA Maharani Laillyza Apriasari; Monita Valentine Silalahi; Isnur Hatta; Juliyatin Putri Utami
ODONTO : Dental Journal Vol 7, No 1 (2020): July 2020
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.7.1.1-8

Abstract

Background: Tuberculosis is an infectious disease which is the second-largest cause of death in the world after HIV / AIDS. Tuberculosis caused by Mycobacterium tuberculosis that usually attacks the lungs but can manifest in the oral mucosa. Clinical manifestations of oral Tuberculosis related to age, sex, duration of treatment, systemic disease, and Multi-Drug Resistant therapy. There is no research on descriptive studies of oral manifestations of tuberculosis patients in South Kalimantan, specifically in Banjarmasin. This study aims to analyze the clinical manifestations of oral Tuberculosis descriptively in South Kalimantan, Indonesia. Method: This was a descriptive analysis with cross-sectional study design, based on history and clinical oral examination. It was used 30 respondents by purposive sampling method. Data were analyzed by Chi-square (p<0.05). Results: During treatment, it showed the correlation between xerostomia and systemic disease (diabetes mellitus and HIV/AIDS) are (p=0.007) and a correlation between xerostomia and duration of treatment (p=0.024). The correlation between candidiasis and systemic disease (p=0.024). The correlation between angular cheilitis and age, sex, duration of treatment, systemic disease, and Multi-Drug Resistant therapy (p>0.05). The clinical manifestations of oral Tuberculosis are xerostomia, candidiasis, and angular cheilitis.Conclusion: The duration of treatment and the systemic diseases are associated with xerostomia and candidiasis in the oral cavity of TB patients.
Hydroxyl Radical Scavenging Activity of Stachytarpheta jamaecensis Root Extract using In Vitro Deoxyribose Degradation Assay Juliyatin Putri Utami; Yusrinie Wasiaturrahmah; Deby Kania Tri Putri
Majalah Obat Tradisional Vol 26, No 2 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.61746

Abstract

Use and demand of traditional medicinal plants currently growing in the direction that research in traditional medicines have also increased. One of the plants that is efficacious as a medicine is S. jamaecensis. This plant is usually used by people as a traditional medicine to treat various diseases. This study aims to determine the antioxidant activity of porterweed root. Antioxidant activity assays performed using hydroxyl radical scavenger that begins with the extraction by maceration. Dry roots of S. jamaecensis  (250 g) was soaked with ethanol 96% for 3x24 hours at room temperature. The liquid extract obtained is evaporated by rotary evaporator and waterbath till viscous extracts is obtained. Then to extract performed phytochemical screening by quantitative and qualitative method. The antioxidant test was carried out using the hydroxyl radical scavenger method. The extract concentrations were varied, namely 125, 250, 500 and 1000 ppm. The data obtained was performed one-way ANOVA test. The results of the phytochemical screening showed the extract contains flavonoids, alcaloids, saponins, phenols and tannins. The results obtained were significant values from the antioxidant test with the antiradical scavenger method, the largest average value of root extract was 60.606% at a concentration of 1000 ppm. The results of spectrophotometric measurements showed that the extract has IC50 was 683.5294 µg/ml, while vitamin C has  IC50 lower value (251.700 µg/ml). Q
MONOSODIUM GLUTAMATE EXPOSURE AT EARLY DEVELOPMENTAL STAGE INCREASES APOPTOSIS AND STEREOTYPIC BEHAVIOR RISKS ON ZEBRAFISH (DANIO RERIO) LARVAE Nia Kurnianingsih; Juliyatin Putri Utami; Nurdiana Nurdiana; Diana Lyrawati
Indonesian Journal of Pharmacy Vol 27 No 3, 2016
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1107.374 KB) | DOI: 10.14499/indonesianjpharm27iss3pp128

Abstract

Excessive glutamate may give neurotoxic effects and contribute to Autism spectrum disorder(ASD). In this study, we investigated prolonged exposure effects of 10 µg/mL Monosodium Glutamate (MSG) on intracellular calcium level, bax, bcl-2, ratio of bax/bcl-2 genes expression, caspase-3, apoptosis of brain cells and stereotypic behavior of Zebrafish (Danio rerio) larvae at early developmental stages. Genes expression were determined by real time PCR, caspase-3 using ELISA, intracellular Ca2+ and apoptotic cells of brain using confocal microscopy, locomotor activity by using crossing lines assay whereas stereotypic behavior by circle swimming. The results indicated that MSG exposure increased brain bax and bcl-2; and caspase-3; intracellular Ca2+; and apoptosis; stereotypic behavior; and decreased locomotor activity. Termination of MSG treatments resulted in recovery of bax, bcl-2, caspase-3 basal levels and stereotypic behavior. In conclusion, MSG exposure at early embryonic stage increased brain cell damage and risk of behavior changes.
ANTIFUNGAL EFFECT OF MAULI BANANA STEM EXTRACT, BASIL LEAF EXTRACT, AND THEIR COMBINATION ON Candida albicans Hadi Waskito; Maharani Laillyza Apriasari; Juliyatin Putri Utami
Dentino : Jurnal Kedokteran Gigi Vol 5, No 2 (2020)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v5i2.8971

Abstract

ABSTRACTBackgrounds: Oral candidiasis is an oral infection caused by abnormal growth of Candida albicans. The use of 0.2% chlorhexidine gluconate as a prophylactic mouthwash is conducted for oral candidiasis therapy. Prolonged use of 0.2% chlorhexidine gluconate is recorded to instigate side effects. Mauli banana stem extract and basil leaf extract demonstrate antifungal properties ascribed to their contents. Objective: To prove that the antifungal effect of 25% concentration of mauli banana stem extract, 12.5% concentration of basil leaf extract, and 25%, 50%, and 75% concentration of mauli banana stem and basil leaf combination extract on Candida albicans are comparable to 0.2% chlorhexidine gluconate. Methods: This study was resolved by applying the true experimental design with post-test only and control group design which consisted of 6 treatments. Group I was given Mauli banana stem extract with 25% concentration, group II was given basil leaf extract with 12.5% concentration, group III, IV, and IV were given the combination of Mauli banana stem and basil leaf extracts with 25%, 50%, and 75% concentrations, respectively. Meanwhile, group VI was given 1% chlorhexidine gluconate as a positive control. Each treatment was served with four times repetition. Antibacterial effectivity was assessed through the inhibition zone measurement of 0.2% chlorhexidine gluconate growth using the diffusion method. Results: This study revealed that the average diameter of inhibition zone formed in group I was 6-6.3 mm, group II was 6-6.2 mm, group III was 6-6.2 mm, group IV was 7-7.2 mm, group V was 10.2-11.4 mm, and group VI was 23.7-24.8 mm. Conclusion: The antifungal effect of mauli banana stem extract at 25% concentration, basil leaf extract at 12.5% concentration, and mauli banana stem and basil leaf combination extract at 25%, 50%, and 75% concentration on Candida albicans has been proven but not equivalent to 0.2% chlorhexidine gluconate.Keywords: Basil leaf extract, Candida albicans,inhibition zone, 0.2% chlorhexidine gluconate, diffusion method, Mauli banana stem extract,.
IN SILICO STUDY OF Stachytarpheta jamaicensis ACTIVE COMPOUNDS AS ANTIBACTERIAL MATERIAL Juliyatin Putri Utami; Sherli Diana; Rahmad Arifin
Dentino : Jurnal Kedokteran Gigi Vol 7, No 1 (2022)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v7i1.13105

Abstract

Background: Stachytarpheta jamaicensis is a wild plant from the Verbenanceae family that grows in tropical areas such as Indonesia. S. jamaecensis extract was proven to contain secondary metabolite compounds such as flavonoids, phenols, saponins, tannins and terpenoids. The active compound of S. jamaecensis can be used as a drug candidate in the medicine field, especially as an antibacterial compound. One of the first steps in predicting the effectiveness of these compounds can be done through in-Silico studies with molecular docking. Objective: This study aims to evaluate the interaction of active compound S. jamaecensis with bacterial proteins through an in silico study. Methods: Using in silico method with computational docking analysis on seven active compounds of S. jamaecensis namely apigenin, luteolin, chlorogenic acid, gamma butyric acid, dopamine, ipolamide and geraniol, as well as two antibacterial drugs (metronidazole and chlorhexidine) as comparisons bound with bacterial cell wall protein, namely Glucosamine-6-phosphate synthase (G1mS). Docking in silico uses Autodock Vina, which is integrated with PyRx 8.0 and visualized using Discovery Studio Visualizer v19.1.0.18287 (2019 version) with data presentation based on docking scores. Conclusion: The best binding affinity score has been the luteolin-G1mS complex with a binding affinity value of -10.8 kcal/mol and was the highest value compared to the comparison ligand binding and the binding of other active compounds of S. jamaecensis.
THE EFFECT OF BINJAI (Mangifera caesia) LEAVES EXTRACT GEL TO COLLAGEN FIBER DENSITY ON WOUND Novia Damayanti; Irham Taufiqurrahman; Juliyatin Putri Utami
Dentino : Jurnal Kedokteran Gigi Vol 7, No 1 (2022)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v7i1.13096

Abstract

Background: Binjai (Mangifera caesia) leaves extract contains flavonoid, saponin, phenolic, tannin, alkaloid and triterpenoid. The said contents are known to help the process of wound healing. Gel formations contains a lot of water, resulting in substance penetration into the tissue will be better if used as wound healing adjuvant therapy. Purpose: To analyze the effect of binjai leaves extract gel (Mangifera caesia) that topically given to collagen fiber density on the wistar rat incision wound. Methods: This research was a true experimental with post test only with control group design that consists of 4 groups. Group I has been given the placebo gel as control, group II, III and IV have been given the binjai leaves extract gel with 5%, 10% and 15% concentration that observed on the 7th day and 14th day. The collagen fiber density assessed by measuring hydroxyproline with Stegmann and Stalder method. Results: The research result shows that the 15% concentration of binjai leaves extract gel has a better effect on collagen fiber density compared to 5% and 10% concentrations. Two-way Anova data analysis revealed that the significant difference average of collagen fiber density of the whole group with the value of sig.p < 0,05. Conclusion: The 15% concentration of binjai leaves extract gel has the most optimal effect compared with the 5% and 10% concentrations to collagen fiber density on the wistar rat incision wound.
EFFECT OF CHANNA MICROPELTES IN THE GRANULATION, FIBROSIS AND NECROSIS OF DIABETIC WOUND HEALING Amy Nindia Carabelly; Juliyatin Putri Utami; Didit Aspriyanto; Muhammad Hasanu Reksi; Dewi Puspitasari; Priyawan Rachmadi
Dentino : Jurnal Kedokteran Gigi Vol 6, No 2 (2021)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v6i2.12001

Abstract

Background: Diabetes mellitus (DM) is characterized by persistent hyperglycemia. The symptoms of DM is delayed wound healing. Delayed wound healing in diabetes will increase the risk of wound complications that will hinder the healing process, and lead to complications such as fibrosis and necrosis. The use of Channa Micropeltes (CM) extract at a dose of 16 mL/kg BW orally is proven to general optimal wound closure and wound contraction clinically in Wistar rats as diabetic model on day 14.However, the histopathological description of wound healing is yet to be known. Objective: To analyze the effect of 16 mL/kg BW dose of CM extract on histopathological changes of wound healing granulation tissue, fibrosis and necrosis in diabetic Wistar rats on day 14. Materials and Methods: This study was a true experimental design with a post-test only control group design. The samples were divided into two groups, namely the diabetic model group given CM extract at 16 mL/kg BW dose for 14 days, and the diabetic model group given BR2 feed only for 14 days. Results: The results of Mann-Whitney U test showed p = 0.003 for granulation tissue, p = 0.411 for fibrosis and p = 1 for necrosis, with the level of significance was p<0.05. Conclusion: The CM extract at 16 mL/kg BW dose affects the histopathological description of granulation tissue which presents a better result than those in the control group but did not affect the features of fibrosis and necrosis in diabetic Wistar rats on day 14. Keywords: Channa Micropeltes, Diabetic wound, Fibrosis, Granulation tissue, Necrosis.
LINKAGES OF Ca V1.2, GLUTAMATE, AND ODONTOBLAST IN THE MECHANISM OF TOOTH PAIN Juliyatin Putri Utami
Dentino : Jurnal Kedokteran Gigi Vol 5, No 1 (2020)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v5i1.8123

Abstract

Background: Odontoblast is often associated with its role as sensory cell in tooth pain. Odontoblasts have ion channels that contribute to the sensitivity and release of neurotransmitters in odontoblast stimuli that are activated in pulp sensory nerve fibers. Review: Ca V1.2 has unexpected plasticity. In dental injury, the appearance of Ca V1.2 canal in odontoblast is known to change, depend on the duration of injury. The dentinal pulp tissue has the ability to release glutamate, which acts as an intercellular mediator to create neuronal signaling communication between inter-odontoblast and odontoblast- trigeminal ganglion nerve (TG). Discussion: Odontoblasts as a mechanosensitive sensory cell are indicated by the role of the TRP transduction receptor and the release of ATP. Though other canals and active compounds in odontoblast are involved, an important role in delivering the sensation of pain also needs to be known. Odontoblast will communicate with paracrine pulp nerves using ATP and glutamate. Ca2+ enters the odontoblast through activated TRP channels and other ion channels, such as L-type VGCC channels (Ca V 1.2). Followed by the release of glutamate from odontoblast through the glutamate-permeable canal, it can trigger the pulp nerve via glutamate metabotropic receptors (mGluRs). Conclusion: There is involvement of Ca V1.2 and glutamate canals in odontoblast in the delivery mechanism of pain.
Correlation between the socio-demographic characteristics and clinical profile with oral manifestations of HIV/AIDS patients Maharani Laillyza Apriasari; Nur Aprilyani; Amy Nindia Carabelly; Juliyatin Putri Utami
Padjadjaran Journal of Dentistry Vol 33, No 1 (2021): March 2021
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol33no1.26025

Abstract

Introduction: Human Immunodeficiency Virus (HIV) exhibits the capability to weaken human immune system. The infected subject will later be more susceptible to suffer from opportunistic diseases when the CD4 cell count is lesser than 200 cell/µL. Oral thrush, periodontal disease and xerostomia are common oral manifestations in AIDS patient which initially indicate the presence of HIV infection. This study was aimed to analyse the correlation between the socio-demographic characteristics and clinical profile with oral manifestations of HIV/AIDS patients. Methods: An analytic study with cross-sectional approach was conducted towards the clinical profile and oral manifestation data of HIV/AIDS patients, which obtained from secondary data in the form of medical record. The 55 samples were taken with total sampling technique. Results: The chi-square test found no significant correlation between HIV/AIDS patients socio-demographic and oral manifestations and several significant correlation of the HIV/AIDS patients' clinical profile with the oral manifestation as follows: the total number of CD4 and ARV therapy duration was significantly correlated with the HIV/AIDS patients with candidiasis and oral thrush (p=0.01); while in patients with periodontal disease was only significantly correlated  with the total number of CD4 (p=0.02); and no significant correlation found in HIV/AIDS patients with xerostomia. Conclusion: There is no correlation between HIV/AIDS patients socio-demographic and oral manifestations. There is a correlation between several HIV/AIDS patients clinical profile with the oral manifestation. The number of CD4 cells and the ARV therapy duration was correlated with patients with candidiasis and oral thrush, while in patients with periodontal disease on correlated with the number and CD4 cells. HIV/AIDS patients with xerostomia have no correlation with any of their clinical profile.
EFEKTIVITAS ANTIBAKTERI EKSTRAK DAUN BINJAI (Mangifera caesia) TERHADAP PERTUMBUHAN BAKTERI Porphyromonas gingivalis (Studi in vitro dengan Metode Dilusi) Nisa Fachrizha Munier; Fransiska Uli Arta Panjaitan; Juliyatin Putri Utami
Dentin Vol 5, No 2 (2021)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACTBackground: Porphyromonas gingivalis is one of bacteria colonizes in subgingivai. This causes of periodontitis. Porphyromonas gingivalis have secretes some compounds can damage periodontal tissue. Chlorhexidine gluconate 0.2% is used as periodontitis treatment, but using long-term can cause side effects. Natural-based medicinal utilizing is considered safe because it has fewer side effects than modern medicine. One of potential plant is Binjai (Mangifera caesia) which has active compounds such as flavonoid, saponin and tannin. These have optimal functions as antibacterial. Purpose: To determined and compared the antibacterial effectiveness of Binjai leaf extract on the growth of Porphyromonas gingivalis bacteria with concentrations of 50%, 80% and 95%. Method: True experimental design of post test only with control group design used 5 treatments: three groups of Binjai leaf extract and two groups of control: positive control and negative control which were repeated 5 times. Measurement of Minimum Inhibitory Concentration (MIC) was calculated using an Uv-Vis Spectrophotometer and measurement of the Minimum Bactericidal Concentration (MBC) was calculated using a colony counter. Result: MIC was obtained at a concentration of 50% and MBC was obtained at a concentration of 80%. Conclusion: The Binjai leaf extract has antibacterial effectiveness against the growth of Porphyromonas gingivalis. Keywords: Antibacterial, Binjai Leaf Extract, MBC, MIC, Porphyromonas gingivalis  ABSTRAKLatar Belakang: Kolonisasi bakteri pada subgingiva yang menyebabkan periodontitis salah satunya adalah Porphyromonas gingivalis. Porphyromonas gingivalis mengeluarkan beberapa senyawa yang dapat merusak jaringan periodontal. Chlorhexidine gluconate 0,2% sering digunakan dalam terapi periodontitis, tetapi penggunaan jangka panjang dapat menimbulkan efek samping. Penggunaan obat berbahan dasar alami dinilai aman karena memiliki efek samping lebih sedikit daripada obat modern, salah satu tanaman berpotensi adalah Mangifera caesia yang memiliki senyawa aktif seperti flavonoid, saponin dan tanin yang memiliki fungsi optimal sebagai antibakteri. Tujuan: Mengetahui dan membandingkan efektivitas antibakteri ekstrak daun binjai (Mangifera caesia) terhadap pertumbuhan bakteri Porphyromonas gingivalis konsentrasi 50%, 80% dan 95%. Metode: True experimental design dengan post test only with control group design menggunakan 5 kelompok perlakuan yaitu 3 kelompok ekstrak daun binjai serta dua kelompok kontrol yaitu kelompok positif dan negatif dengan 5 kali pengulangan. Pengukuran Konsentrasi Hambat Minimum (KHM) dilakukan menggunakan alat Spektrofotometer Uv-Vis dan pengukuran Konsentrasi Bunuh Minimum (KBM) dilakukan menggunakan colony counter. Hasil: KHM didapatkan pada konsentrasi 50% dan KBM didapatkan pada konsentrasi 80%. Kesimpulan: Ekstrak daun binjai (Mangifera caesia) memiliki efektivitas antibakteri terhadap pertumbuhan Porphyromonas gingivalis. Kata Kunci: Antibakteri, Ekstrak Daun Binjai, KBM, KHM, Porphyromonas gingivalis
Co-Authors Agung Satria Wardhana Ainna Dewi Iriani Amy Nindia Carabelly, Amy Nindia Anisa Novia Farrasti Annisa Noviany Aspriyanto, Didit Beta Widya Oktiani Dewi Purboningsih Dewi Puspitasari Diana Lyrawati Diana Wibowo Erika Norfitriyah Eriwati, Yosi Kusuma Erni Marlina Firda Damayanti Fransiska Uli Arta Panjaitan Gita Puspa Ningrum Hadi Waskito Haluanry Doane Santoso Hatta, Isnur Ichrom Nahzi, Muhammad Yanuar Kurnianingsih, Nia Maharani Laillyza Apriasari Maharani Laillyza Apriasari Maria Tanumihardja, Maria Melisa Budipramana, Melisa Milka Widya Sari Mira Hadistiana Monita Valentine Silalahi Muhammad Adeya Herdira Putra Muhammad Akbar Baitullah Muhammad Hasanu Reksi Muhammad Reza Faisal, Muhammad Reza Muhammad Rizal Bima Saputra Nanda Putri Arini Nia Kurnianingsih Nisa Fachrizha Munier Novi Dwi Maulida Novia Damayanti Nur Aprilyani Nurdiana Nurdiana Panghiyangani, Roselina Priyawan Rachmadi Rahmad Arifin Safa Muzdalifah Sandra Bhakti Mafriana Sari, Galuh Dwinta Sherli Diana Tri Putri, Deby Kania Yunike Christanti Yusrinie Wasiaturrahmah