Article Per Year (5 Year)
p-Index From 2019 - 2024
0.23
P-Index
This Author published in this journals
All Journal Dentino: Jurnal Kedokteran Gigi
Alya Nur Fadhilah
Unknown Affiliation
Dentistry

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
THE EFFECT OF BIOLOGICAL MEMBRANES TO FIBROBLAST PROLIFERATION: PLATELET-RICH FIBRIN RELEASATE VS AMNIOTIC (Research report) Rezmelia Sari; Sri Pramestri Lastianny; Alya Nur Fadhilah
Dentino : Jurnal Kedokteran Gigi Vol 4, No 1 (2019)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v4i1.6181

Abstract

Background: Both amniotic and platelet-rich fibrin membranes are used to enhance open wound healing process clinically. The growth factors of these membranes are almost similar but the certain mechanism is still unclear especially in inducing fibroblast proliferation. Objective: to compare the effect of both membranes to fibroblast proliferation. Methods: This in vitro study was using fibroblast from periodontal ligament. The fibroblasts were cultured and then divided into 3 groups: fibroblasts with PRF releasate membrane (group I), fibroblasts only (group II), and fibroblasts with amniotic membranes (group III). The cells were observed in 24, 48 and 72 hours. Proliferation was tested by MTT assay and data was analyzed by two-way ANOVA followed by post-hoc test. Results: It showed that PRF releasate membrane induced fibroblast proliferation higher than amniotic in the first 24 hours meanwhile amniotic induced it two-fold in the next 24 hours. However, in the following time there were no significant differences between groups. Conclusion: It can be concluded that PRF membranes and amniotic membranes have the ability to accelerate proliferation of fibroblasts but have different effects at the time of induction.
Co-Authors Sari, Rezmelia Sri Pramestri Lastianny, Sri Pramestri