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Haryo Seto Wicaksono
Lab. Fisiologi Hewan, **Lab. Struktur dan Perkembangan Hewan Jurusan Biologi FMIPA Universitas Udayana Kampus Bukit Jimbaran, Kuta
Agriculture, Biological Sciences & Forestry

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STRUKTUR HATI MENCIT (Mus musculus L.) SETELAH PEMBERIAN EKSTRAK DAUN KALIANDRA MERAH (Calliandra calothyrsus Meissn.) Haryo Seto Wicaksono; Inna Narayani; Iriani Setyawati
SIMBIOSIS Vol 3 No 1 (2015)
Publisher : Jurusan Biologi Universitas Udayana

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Abstract

This research aims to determine the effect red calliandra leaf extract on weight, anatomy andhistology of male mice liver. Treatment was administered orally with varying doses (2, 4, 6mg/ kg). Control grups was given 0,9% NaCl. This study used a completely randomizeddesign (CRD), consisting of 12 groups with three replications. Histological observationsshowed that red calliandra leaf extract significantly affected the damage of male mice liver.Damage level of nucleus pyknotic and fatty degeneration increased in line with the increasingdoses in treatment for 7 and 21 days, as well as the dilation of central venous in treatment for7 days. The damage increase in line with the leght of treatment in the fatty degeneration (dose2 mg/kg bw), nuclues pyknotic (doses 2 and 6 mg/kg bw), infiltration of inflammatory cells(dose 4 mg/kg bw), sinusoid congestion (doses 2, 4 and 6 mg/kg bw), and central venousdilatation (dose 2 and 4 mg/ kg bw).Keywords : Red calliandra, male mice, liver histology
Co-Authors Inna Narayani Iriani Setyawati