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All Journal Majalah Obstetri dan Ginekologi Indian Journal of Forensic Medicine & Toxicology
Erry Gumilar Dachlan
Department Of Obstetrics And Gynecology, Faculty Of Medicine, Universitas Airlangga, Surabaya
Health Professions Medicine & Pharmacology Public Health

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Maternal and Perinatal Outcomes in Uncorrected Tetralogy of Fallot Khanisyah Erza Gumilar; Christina Meilani Susanto; Erry Gumilar Dachlan
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.15023

Abstract

Background: Tetralogy of Fallot (TOF) is the most common congenital heart disease in the population.Correction of TOF during infancy or childhood may increase the quality of patient’s life. Uncorrected TOFmay cause further complications later on. Pregnancy with uncorrected TOF may cause complications onboth maternal and fetal sides.Objective: to analyze maternal and perinatal outcomes in patients with uncorrected TOF during pregnancy.Methods: This is a retrospective study. A total of 8 pregnant women diagnosed with TOF registered inthe Obstetric-Cardiac unit in 3 years (2016-2018). Medical records were reviewed for clinical assessment,echocardiography results, and therapy during hospitalization. Patients were contacted by telephone to providean obstetric history, including details of pregnancy and delivery. Five of 7 patients able to be contacted, andhome visits were done to evaluate their conditions.Results: There were 8 pregnant women with uncorrected TOF. Most cases (87,5%) were first diagnosedduring pregnancy and delivery. Intra-Uterine Growth Restriction (IUGR) and abortion (62.5% and 25%,respectively) were the most obstetric complications. Cardiac complications were cardiogenic shock (12.5%),thromboembolic (12.5%), and various degree of heart failure (62.5%). The number of Small for GestationalAge (SGA) was 66.7%. Incidence of congenital heart disease (CHD) in the fetus was 20%. One death caseand 2 abortions from a total of 8 cases were found.Conclusion: TOF may cause many maternal and fetal complications. The most common maternalcomplications are heart failure, cardiogenic shock and thromboembolic, while perinatal complicationsinclude IUGR, SGA and abortion.
Penurunan progesterone-induced blocking factor (PIBF) sebagai penanda preeklampsia Achmad Salman; Budi Wicaksono; Erry Gumilar Dachlan; Widjiati Widjiati
Majalah Obstetri dan Ginekologi Vol. 24 No. 1 (2016): Januari - April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (94.819 KB) | DOI: 10.20473/mog.V24I12016.13-18

Abstract

Background: Pathogenesis of preeclampsia still a controversial research objects. Progesterone induced blocking factor has protective effects in pregnancy.Objectives: To compare PIBF serum level and placental weight and investigate correlation between both in preeclampsia.Methods: This experimental study used 16 Mus musculus with normal pregnancy and 16 Mus musculus that were injected with anti Qa-2 to create a preeclampsia model. Terminations of were performed in day 16th, followed by ELISA examination for PIBF serum level and placental weight measurement.Result: PIBF serum level significantly reduced on preeclampsia model  compared with control (33,21±29,36 ng/ml vs 105,76±59,69 ng/ml; p<0,05). There was no different of placental weight in preeclampsia model compared with control (97,75±50,74 mg vs 116,09±44,45 mg; p>0,05). There was no significant correlation between PIBF serum level and placental weight.Conclusion: Decreased of PIBF serum level could be used as a marker of preeclampsia. Decreased of PIBF serum level may be correlate with placental pathology in preeclampsia.
Comparison of the provision of champedon trunk shell capsule extract and artesunate on placental histopathologic classification in pregnant mice (Mus musculus) malaria model Achmad Yunus; Budi Prasetyo; Erry Gumilar Dachlan; Aty Widyawaruyanti; Widjiati Widjiati
Majalah Obstetri dan Ginekologi Vol. 25 No. 3 (2017): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (218.244 KB) | DOI: 10.20473/mog.V25I32017.71-76

Abstract

Objectives: To compare the effect of chemphedon trunk shell capsule extract with artesunate on placental histopathologic classification in pregnant mice malaria’s models.Materials and Methods: This study was a randomized experi-mental laboratory study in BALBc strains mice with controls. A total of 30 pregnant mice were divided into 3 groups. On day 10 each group was infected with P. berghei. Furthermore, on day 11 each group was subjected to thin blood smear examination and subsequent infection when administered antimalarial positive. Group P1 received Chemphedon trunk shell extract 100 mg/kg BW/day per sonde two times per day for 5 days. Group P2 received 36.4 mg artesunate/kg BW/day for 3 days followed by CMC Na per sonde for 2 days, and group P3 received placebo (CMC Na) for 5 days. On day 16 the mice were dissected on 16 days of pregnancy and the placenta was taken and preparations were made to observe histopathological classification of the placenta according to Rogerson. Grouping was performed accor-ding to placental histopathological classification by Rogerson.Results: Groups receiving cemphedon trunk shell capsule extract, artesunate and placebo revealed p=0.004 (p<0.05), showing that there were two groups with significant difference. To determine which group had significant difference, the test was followed by Mann-Whitney post-hoc test. The results showed chempedon trunk shell capsule group and placebo obtained p=0.007 (p<0.05), indicating significance. Artesunate and placebo groups revealed p=0.003 (p<0.05), also indicating significance. The test results of chemphedon trunk shell capsule extract and artesunate groups showed p=0.475 (p<0.05), indicating no significant differences.Conclusion: Placental histopathologic classification on pregnant mice malaria’s model that received antimalarial chemphedon trunk shell capsule extract of 100 mg/kg BW is better than place-bo and equivalent to artesunate of 36.4mg/kg BW.
Co-Authors Achmad Salman Achmad Yunus Aty Widyawaruyanti Budi Prasetyo Budi Wicaksono Christina Meilani Susanto Khanisyah Erza Gumilar Widjiati Widjiati Widjiati Widjiati