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All Journal Majalah Obstetri dan Ginekologi Indonesian Journal of Cancer
Widjiati Widjiati
Department of Embryology, Faculty of Veterinary Medicine, Airlangga University, Surabaya
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Effect of prenatal Mozart composition on Brain Derived Neurotrophic Factor expression in cerebrum and cerebellum of Rattus norvegicus offspring from Food Restriction 50 model Yulia Putri Permatasari; Widjiati Widjiati; Hermanto Tri Joewono
Majalah Obstetri dan Ginekologi Vol. 26 No. 1 (2018): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (255.35 KB) | DOI: 10.20473/mog.V26I12018.1-6

Abstract

Objectives: To analyze the difference of BDNF expression on Rattus norvegicus offspring FR50 model in cerebrum and cerebellum between Mozart composition stimulation group and control.Materials and Methods: An analytical experimental study with single blind randomized post test only control group using animal subjects Rattus norvegicus FR50 model. This study was conducted at animal laboratory, Faculty of Veterinary Medicine, Airlangga University. Animal subjects were divided into Mozart music stimulation group and control. The BDNF expression was analyzed using comparison test, with significancy p<0,05.Results: There was no difference of BDNF expression on Rattus norvegicus offspring FR50 model between Mozart music stimu-lation group and control in cerebrum with p=0.495 (mean Mozart group 6.89+2.52 vs control 6.22+1.99), and cerebellum with p=0.146 (mean Mozart group 7.41+2.67 vs control 5.73+2.45).Conclusions: There was no difference of BDNF expression between Mozart composition stimulation group and control in the cerebrum and cerebellum of Rattus norvegicus offspring FR50 model.
Effects of Curcumin on Vascular Endothelial Growth Factor Expression on Rattus norvegicus Cervical Cancer Xenograft Model Laili Muninggar; Widjiati Widjiati; Indra Yuliati; Brahmana Askandar; Poedjo Hartono
Indonesian Journal of Cancer Vol 12, No 3 (2018): July-September
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (907.462 KB) | DOI: 10.33371/ijoc.v12i3.616

Abstract

Objective: To analyze the effect of curcumin in VEGF expression on Rattus norvegicus cervical cancer cell xenograft model.Methods: An experimental study with randomized post test only control group design. The subjects were Rattus norvegicus (Sprague Dawley), inoculated with He-la cervical cancer cells from American Type Culture Collection (ATCC) processed in stem cell laboratory Institute of Tropical Disease (ITD) Airlangga University. 5x106 of He-La cells were injected subcutaneously in dorsal flank area of Rattus norvegicus. After 30 days of observation we performed histopathological examination of xenograft tissue and randomized into 2 groups which were given curcumin orally 1000 mg/kg (curcumin group) vs. no therapy (control group). After another 30 days the xenograft tissue was dissected and underwent immunochemistry examination for VEGF expression.Results: 32 samples of Rattus norvegicus were divided into 2 groups, In curcumin group the VEGF median expression was 2,2 (0,3-7,6) and in control group the VEGF median expression was 6,6 (1,2-12). There was a statistically significant difference with p value =0,009 with Mann Whitney test (p<0,05).Conclusion: VEGF expression in Rattus norvegicus xenograft model of cervical cancer was suppressed by giving Curcumin 1000 mg/kgBB orally.
Co-Authors Brahmana Askandar Tjokroprawiro Hermanto Tri Joewono Indra Yuliati Laili Muninggar Poedjo Hartono Yulia Putri Permatasari