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All Journal STOMATOGNATIC- Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi)
Malianawati Fauzia
Faculty Of Dentistry, Universitas Brawijaya, Malang, Indonesia
Dentistry Medicine & Pharmacology

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The effect of lime (Citrus Aurantifola Swingle) peel extract in periodontal dressings on the number of fibroblasts in the gingival wound healing process Malianawati Fauzia; Audia Putri Dewanti
Dental Journal (Majalah Kedokteran Gigi) Vol. 55 No. 2 (2022): June 2022
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v55.i2.p81-87

Abstract

Background: Periodontal dressing commonly used in dentistry today does not contain compounds that can accelerate wound healing. Lime (Citrus aurantifolia Swingle) peel contains flavonoids that play a role in increasing fibroblast cells so that they can accelerate the healing process. Periodontal dressings supplemented with lime (Citrus aurantifolia Swingle) peel extract are expected to provide an alternative material that can accelerate wound healing in addition to closure. Purpose: The study aims to determine the effect of adding lime (Citrus aurantifolia Swingle) peel extract to periodontal dressings on the increase in the number of fibroblasts in the gingival healing process. Methods: The study was conducted in an experimental laboratory in vivo. The study used a post-randomised control group of 32 rabbits with lesions of the mandibular gingiva using a 2 mm diameter punch biopsy. The experimental animals were divided into 8 groups, namely the control group, which was treated with periodontal dressings without the addition of lime (Citrus aurantifolia Swingle) peel extract, and the treatment group, which was treated with periodontal dressings with the addition of the extract. Histological observations of the tissues were performed with HE staining to count the number of fibroblasts. Results: Statistical test results showed that there was a significant difference in the number of fibroblasts between the control group and the treatment group on day 3 and day 5 (ANOVA, p <0.05). Conclusion: Adding extra lime (Citrus aurantifolia Swingle) peel to the periodontal dressing increases the number of fibroblast cells after gum injury.
Hubungan Ekspresi Osteocalcin dan Interleukin-1β dengan Status Inflamasi Periodontal Rahmavidyanti Priyanto; Malianawati Fauzia; Ariyati Retno Pratiwi; Neny Roeswahjuni; Novi Khila Firani
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 19 No 2 (2022)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/stoma.v19i2.34736

Abstract

Periodontitis is inflammation of the periodontal tissue that can cause progressive damage to the periodontal ligament and alveolar bone. Clinical examination to determine the degree of damage to the alveolar bone using a periodontal probe instrument or probing. Cellular activity in the gingival crevicular fluid is thought to be a biomarker to determine the inflammatory status of the periodontal tissue. Cellular immune responses suggest the role of cytokines in the pathogenesis of gingivitis and periodontitis. The cytokines observed in this study were the protein Osteocalcin and Interleukin-1β (IL-1β) in the gingival crevicular fluid (GCF). In this study, 67 patients were examined for the condition of their periodontal tissues including the severity of gingivitis and periodontal probing. The gingivitis group was divided into 4 groups, namely normal, mild, moderate, and severe. Meanwhile, for probing samples were grouped based on probing into 3 groups. Group I (0-3 mm), group II (3.1-5 mm) and group III (> 5 mm). GCF was obtained using paper points that were left in the gingival sulcus for 30 seconds. Then paper points are put into cryovial tubes which are sent to the laboratory for ELISA test. The observed data on the expression of Osteocalcin and IL-1β were then performed statistical tests. Osteocalcin and IL-1β expression showed a significant difference with the severity of gingivitis cases. In the other hand, it did not show a significant difference with difference of periodontal pocket depth. Osteocalcin and IL-1β expression associated with the severity of gingivitis cases.
The effect of nanoparticle tooth grafts on osteoblast stimulation in the first stages of the bone healing process in Wistar rats compared to the micro-tooth graft technique Ega Lucida Chandra Kumala; Malianawati Fauzia; Hana Salsabila Junivianti
Dental Journal Vol. 56 No. 3 (2023): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v56.i3.p184-188

Abstract

Background: The use of a bone graft in bone regeneration is challenging. Tooth graft material has been used as a bone graft alternative due to its similar composition of organic and inorganic materials close to the bone. Recently, nanotechnology has been used to improve bone graft quality. The osteoconduction rate in the defect area represents the bone graft quality. Purpose: This study aimed to compare the number of osteoblasts using nano-tooth grafts and micro-tooth grafts in Wistar rats. Methods: Wistar rats were divided into six groups: the negative control groups (examined on days 7 and 14), the micro-tooth graft groups (examined on days 7 and 14), and the nano-tooth graft groups (examined on days 7 and 14). The control group received nothing, the micro-tooth group received a micro-size tooth graft, and the nano-tooth graft group received a nano-size tooth graft on the injured femur. Histological observations of osteoblasts were carried out using a light microscope with 1000x magnification. Data were analyzed using one-way analysis of variance and least significant difference tests. Results: On day 7, the nano-tooth graft group showed a higher osteoblast number (11.75) than the micro-tooth graft group (7.5) (p = 0.039). There was no significant difference in the micro-tooth graft group compared to the control (p > 0.05). On day 14, the nano-tooth graft group showed a decrease in osteoblast number close to normal (control) (p > 0.05), while the micro-tooth graft group still experienced significant elevation. Conclusion: Nano-tooth grafts accelerate the stimulation of osteoblasts in the first stages of the healing process compared to micro-tooth grafts.
Co-Authors Ariyati Retno Pratiwi Audia Putri Dewanti Ega Lucida Chandra Kumala Hana Salsabila Junivianti Neny Roeswahjuni Novi Khila Firani Rahmavidyanti Priyanto