Claim Missing Document
Check
Articles

Found 2 Documents
Search

CONDYLOMA LATA IN A 21-YEAR-OLD MALE TREATED WITH DOXYCYCLINE: A CASE REPORT Minarto, Hendra
Jurnal Biomedik : JBM Vol 6, No 2 (2014): JURNAL BIOMEDIK : JBM Juli 2014
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.6.2.2014.5555

Abstract

Abstrak: Kondiloma lata merupakan salah satu manifestasi sifilis sekunder yang disebabkan oleh Treponema pallidum. Manifestasi klinis kondiloma lata berupa papul-papul berwarna putih atau keabuan pada daerah tubuh yang hangat dan lembab. Sifilis memerlukan perhatian serius karena penyakit ini merupakan salah satu faktor risiko transmisi human immunodeficiency virus (HIV) di seluruh dunia. Kami melaporkan satu kasus kondiloma lata pada seorang laki-laki berusia 21 tahun di daerah penis, skrotum, perineal, dan perianal sejak 2 bulan lalu, yang diterapi dengan doksisiklin 2 x 100 mg selama 30 hari. Pada pemeriksaan serologik awal didapatkan hasil reaktif untuk tes VDRL (1/256), tes RPR (1/512) dan tes TPHA (1/5120). Perbaikan signifikan terlihat setelah 30 hari terapi doksisiklin dimana semua lesi menghilang. Pemeriksaan serologik 3 bulan setelah awal terapi menunjukkan penurunan titer sebanyak empat kali lipat untuk tes VDRL (1/64), tes RPR (1/128), dan enam kali lipat untuk tes TPHA (1/640). Simpulan: Telah dilaporkan kasus kondiloma lata dengan diagnosis ditegakkan berdasarkan anamnesis, pemeriksaan fisik, dan serologik. Terapi doksisiklin selama 30 hari memberikan hasil yang memuaskan. Pemeriksaan serologik harus dilakukan pada bulan ke-6 dan 12 untuk monitoring keberhasilan terapi. Kata kunci: kondiloma lata, sifilis sekunder, Treponema pallidum, doksisiklin   Abstract: Condyloma lata is one manifestation of secondary syphilis caused by Treponema pallidum. It is described clinically as multiple whitish or gray papules found in warm and moist areas. Syphilis requires serious attention since it still remains a risk factor of human immunodeficiency virus (HIV) transmission all around the world. We reported a case of a 21-year-old male suffered from condyloma lata on his penile, scrotal, perineal, and perianal regions for 2 months and treated with 30 days course of 100 mg doxycyline two times daily. Early serologic examinations revealed reactive values of VDRL test (1/256), RPR test (1/512), and TPHA test (1:5120). Significant improvement was observed after 30 days course of doxycyline therapy where all lesions have resolved. Further serologic examinations as follow up showed a fourfold titre decrease of VDRL test (1/64), RPR test (1/128) and sixfold titre decrease of TPHA test (1/640) 3 months after the initial therapy. Conclusion: The diagnosis of condyloma lata in this case was established based on anamnesis, physical examination, and serologic findings. Treatment with doxycycline gave satisfactory result. Serologic examination as follow up needs to be performed at 6 and 12-months after the initial treatment to monitor the success of therapy. Keywords: condyloma lata, secondary syphilis, Treponema pallidum, doxycycline.
Seroprevalence of syphilis and herpes simplex virus type 2 and its association with sexual behaviour factors (a cross-sectional study among men who have sex with men in Manado, Indonesia) Niode, Nurdjanah J.; Minarto, Hendra; Mitaart, Andravita F.; Kapantow, Grace M.; Kandou, Renate T.
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 2, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Aims: This study investigated the seroprevalence and sexual risk behavior factors associated with syphilis and herpes simplex virus type 2 (HSV-2) among men who have sex with men (MSM), in Manado, Indonesia. Methods: Serum samples and questionnaires regarding their socio-demographic and sexual behaviour were collected from 60 MSM in Manado. Samples were screened for anti-HSV-2 IgG for herpes, the Venereal Disease Research Laboratory (VDRL) and the Treponema Pallidum Haemagglutination (TPHA) test for syphilis. A cross sectional method was used in this study. Results: Of 60 MSM (median age was 20 years), 35% had homosexual orientation and 65% had bisexual orientation. First sexual intercourse of most participants (48.3%) within 16 to 18 years old. In the last 12 months, most participants (55%) had only one male sex partner. There were 63.3% and 16.7% participants performed oral and anal intercourse. About 23.3% participants used condom consistently, but only 35.7% used compatible lubricant. Seropositivity of VDRL and TPHA was detected in 5% participants and anti-HSV-2 IgG in 23.3% participants. The positive serology test for syphilis was associated with sexual intercourse mode (p= 0.001). Significant association was found between anti-HSV-2 IgG seropositivity and condom-use behaviour (p=0,028). Conclusions: The study demonstrated 5% and 23.3% positivity of serology test for syphilis and anti-HSV-2 IgG respectively. Seropositivity of syphilis was correlated with oral and anal intercourse while HSV-2 with no condom-use behaviour among MSM in Manado, Indonesia.