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Abdul Punagi
Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Materials Science & Nanotechnology Neuroscience

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Comparison of Platelet-Lymphocyte Ratio Before and After Chemotherapy in Nasopharyngeal Carcinoma Based on Histopathology Aksmitayani Aksmitayani; Abdul Kadir; Muhammad Fajar Perkasa; Abdul Punagi
Nusantara Medical Science Journal Volume 7 Issue 1, January - June 2022
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v7i1.18961

Abstract

Introduction: Nasopharyngeal carcinoma (NPC) is a non-lymphomatous squamous cell carcinoma in the nasopharyngeal epithelial layer which can be classified into three categories with different prognosis based on histopathological examination. This study aimed to compare platelet-lymphocyte ratio (PLR) in NPC patients before and after chemotherapy based on histopathological type. Method: this cohort study recorded data from medical records. The histopathological type, chemotherapy regimen, clinical stage, and PLR of NPC patients were recorded and compared before and after therapy using paired T-test and Wilcoxon test. The prognostic strength of PLR and the value of the cut-off point was determined by looking at the Area Under Curve (AUC) value using the Receiver Operating Characteristic (ROC) curve method. Results: A total of 44 NPC patients received chemotherapy for three cycles, including 21 patients with NPC type-2 and 23 patients with NPC type-3. There were significant differences in the average PLR before and after undergoing three cycles of chemotherapy in type III NPC (p=0.023). At the same time, there were no statistically significant differences in type-II NPC (p=0.131). The prognostic ability of pre-chemotherapy PLR in assessing disease progression in type II NPC was good (AUC=0.763) with 100.0% sensitivity and 73.68% specificity. In type III NPC, the prognostic ability of PLR was very good (AUC 0.881) with 100% sensitivity value and 76.19% specificity. Conclusion: A significant PLR decrease was obtained after the 3rd cycle of chemotherapy in type III NPC following brexel-cisplatin regimen but not in type II NPC. This is probably due to the use of a cisplatin therapy regimen that is more responsive to type III NPC. In addition, examining PLR value before undergoing chemotherapy can be a predictor in assessing disease progression in type III NPC patients.
The Examination of Olfactory Function and Mucocilliary Transport in Gas Station Officers in Makassar, Indonesia Rahmat Hidayat; Eka Savitri; Muhammad Fadjar Perkasa; Abdul Punagi
Nusantara Medical Science Journal Volume 7 Issue 1, January - June 2022
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v7i1.19233

Abstract

Introduction: Chronic exposure to fuel oil can cause chemical burns to the olfactory epithelium, which can cause anosmia. This study aimed to compare mucociliary transport time and olfactory function between operator and non-operator officers at gas stations. Methods: This cross-sectional study was conducted from September to November 2020 and involved 40 subjects divided into two equal groups each consisting of 20 gas station operators and non-operators, respectively. The examination of mucociliary transport time was carried out by saccharin test, while the olfactory function was examined by assessing e olfactory threshold, discrimination, and identification (TDI) score using the Sniffin sticks test. Results: There was a significant difference in the mean mucociliary transport time and olfactory function between gas station operators and non-operators (P<0.001). In addition, there was also a significant correlation between the mucociliary transit time and olfactory function (p<0.05), with a strong negative correlation coefficient (r=-0.620). Therefore, the longer the mucociliary transit time, the gas station attendant's olfactory function will decrease. Conclusion: mucociliary transport time and olfactory function in non-operator public gas station officers were better than operators, probably because inhalation of chemical pollutants induces the release of proinflammatory cytokines, chronic inflammation of the nasal mucosa results in impaired olfactory cells and mucin glands.
Correlation Between Immunohistochemical Expression of Epstein-Barr Virus Latent Membrane Protein-1 (LMP-1) and Clinical Stages of Sinonasal Carcinoma Liza Retno Dewi; Muhammad Amsyar Akil; Eka Savitri; Abdul Punagi
Nusantara Medical Science Journal Volume 7 Issue 2, July - December 2022
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v7i2.20037

Abstract

Introduction: Sinonasal tumors are rarely found. The protected nature of the sinuses makes early detection of tumors growing in these areas difficult. The Epstein-Barr virus is one of the most common viruses found in humans; which expresses Latent Membrane Protein-1 (LMP-1) that can transform cell lines and alter cell phenotype due to its oncogenic potential. Objective: To investigate the relationship between immunohistochemical expression of Latent Membrane Protein-1 (LMP-1) from Epstein-Barr virus and clinical stages of sinonasal carcinoma. Methods: This cross-sectional study was carried out in DR. Wahidin Sudirohusodo General Hospital and anatomic pathology of Hasanuddin University Hospital, Makassar, South Sulawesi, Indonesia, from October 2016 to March 2017. Histopathological samples from biopsy specimen of all subjects diagnosed with sinonasal carcinoma in Otorhinolaryngology-Head and Neck Surgery outpatient clinic were taken and examined for LMP-1 expression using immunohistochemical staining. The samples were taken from paraffin block from patients. Result: There were 33 males (67.3%) and 16 females (32.7%) with sinonasal carcinoma who participated in this study. The majority of participants aged ≥50 years (25 people, 51.0%) and worked as farmers (27 people, 55.1%). A significant correlation between LMP-1 expression and sinonasal carcinoma clinical stages was found (Spearman’s correlation r = 0.355 and p <0.001). Conclusion: Higher LMP-1 expression correlates with higher sinonasal carcinoma clinical stage in patients aged <50 years.
Co-Authors Abdul Kadir Aksmitayani Aksmitayani Eka Savitri Liza Retno Dewi Muhammad Amsyar Akil Muhammad Fadjar Perkasa, Muhammad Fadjar Muhammad Fajar Perkasa Rahmat Hidayat