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All Journal E-Jurnal Medika Udayana Jurnal Kedokteran Brawijaya The Indonesian Biomedical Journal Nusantara Medical Science Journal Oto Rhino Laryngologica Indonesiana Majalah Sainstekes

Muhammad Fadjar Perkasa, Muhammad Fadjar

Departemen THT-KL Fakultas Fakultas Kedokteran Universitas Hasanuddin, Makassar, Indonesia

Author-ID : 601600

Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Health Professions Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Articles

Adenoma pleomorfik kelenjar saliva pada bayi Perkasa, Muhammad Fadjar; Kurniawati, Dewi
Oto Rhino Laryngologica Indonesiana Vol 43, No 2 (2013): Volume 43, No. 2 July - December 2013
Publisher : PERHATI-KL

Latar belakang: Adenoma pleomorfik adalah tumor kelenjar saliva yang paling sering ditemukan, yang merupakan suatu tumor jinak campuran yang terdiri dari sel-sel epitel dan diferensiasi mesenkimal. Adenomapleomorfik (AP) paling banyak ditemukan pada kelenjar saliva minor yang terdapat pada palatum, kemudian bibir, dasar rongga mulut, lidah, tonsil, faring, daerah retromolar dan rongga hidung. Kasus adenoma pleomorfik pada tonsil sangat jarang ditemukan, insiden AP lebih sering pada wanita dibanding pria dan terjadi pada usia 40-60 tahun, paling banyak pada usia 43-46 tahun. Tujuan: Melaporkan satu kasus AP pada tonsil seorang bayi yangberumur 7 bulan yang dilakukan tindakan ekstirpasi tumor trans-oral. Kasus: Seorang bayi perempuan umur 7 bulan, berat 6 kg datang dengan keluhan utama mendengkur. Dari alloanamnesis (ibunya) riwayat mendengkur dialami sejak anak berusia 4 bulan, bunyi napas bertambah keras sejalan dengan bertambahnya umur. Pada usia 6bulan pasien mulai sesak napas terutama saat minum susu, kadang-kadang disertai regurgitasi saat minum susu, tidak ada riwayat demam, kejang dan influenza sebelumnya. Dari pemeriksaan fisis Telinga Hidung Tenggorok (THT) tidak ditemukan kelainan pada pemeriksaan otoskopi dan rinoskopi anterior. Pada pemeriksaan faringoskopiditemukan massa pada pole atas fossa tonsilaris, tonsil T1 di inferior dari massa. Tonsil kiri T1 tenang. Bayi ini didiagnosis tumor tonsil kanan. Penatalaksanaan: Dilakukan tindakan eksterpasi tumor pada rongga mulut. Hasil pemeriksaan histopatologik jaringan tumor setelah tindakan eksterpasi tumor trans oral adalah adenoma pleomorfik sesuai dengan gambaran makroskopis massa. Kesimpulan: Suatu kasus tumor kelenjar saliva, yang sangat jarang terjadi pada anak.Kata kunci : Adenoma pleomorfik, tumor kelenjar saliva, ekstirpasi tumor trans oral.

Analysis of Lamina Papyracea Area and Ethmoid Sinus Volume in Indonesian Patients Undergoing Paranasal Sinus CT Scan Wahyuni, Wahyuni; Idris, Nurlaily; Muis, Mirna; Zainuddin, Andi Alfian; Perkasa, Muhammad Fadjar; Ilyas, Muhammad
Jurnal Kedokteran Brawijaya Vol 31, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2020.031.01.6

Of the rhinosinusitis (CRS) patients, half of whom require surgical intervention. Functional endoscopic sinus surgery (FESS) is a standard treatment of CRS and sinonasal polyposis. Orbito-ocular complications can occur during FESS. The lamina papyracea (LP) is the weakest point of the medial wall of the orbit. The variability in the size and shape of the paranasal sinuses is important in the FESS procedure. The ethmoid sinus is the most complex paranasal sinuses. Preoperative evaluation using computed tomography (CT) is mandatory for all patients undergoing FESS. This study aimed to determine the lamina papyracea area and ethmoid sinuses volume in patients who underwent a CT scan of paranasal sinuses. This study was a descriptive study on 103 patients who underwent a CT scan of paranasal sinuses in the Radiology Department of Hasanuddin University General Hospital, Makassar, from January to August 2019. The lamina papyracea area and ethmoid sinus volume were measured based on age and gender. The results showed that the average of lamina papyracea size and ethmoid sinus volume was greater in males than in females. There was a correlation between age and posterior height of left lamina papyracea (p=0.02), but no correlation between ethmoid sinuses volume and age.

Korelasi Skor Lund-Mackay dan Volume Cairan Sinus Berdasarkan Gambaran CT-Scan Sinus Paranasalis 3D dengan Skor SNOT-22 pada Pasien RSK Tanpa dan dengan Polip Muhammad Ridha Maulana; Nurlaily Idris; Nikmatia Latief; Burhanuddin Bahar; Muhammad Fadjar Perkasa; Muhammad Ilyas
Majalah Sainstekes Vol 6, No 2 (2019): DESEMBER 2019
Publisher : Lembaga Penelitian Universitas YARSI

The aim of this study is to determine the correlation between Lund-Mackay scores and sinus fluid volume based on 3D CT paranasal sinus scan with SNOT-22 score in patients with chronic rhinosinusitis without and with polyps. This research was conducted at the Department of Radiology Hasanuddin University Hospital Makassar from April to June 2019. Samples were 38 patients without and with polyps in age ? 18 years. The method used is the Spearman rho test. The results showed a correlation between sinus fluid volume and SNOT-22 score in patients with chronic rhinosinusitis without polyps n value 25, p value 0.042 (p less than 0.05), the higher the sinus fluid volume, means the SNOT-22 score was higher in patients with chronic rhinosinusitis without polyps. There was no correlation between sinus fluid volume and SNOT-22 score in patients with chronic rhinosinusitis with polyps n value 13, p value 0.077 (p less than 0.05), there was not any correlation between Lund-Mackay scores and SNOT-22 scores in patients with chronic rhinosinusitis without and with polyps.

Comparison of The Means of Argyrophilic Nucleolar Organizer Region (mAgNOR) Pre- and Post-Therapy in Nasopharyngeal Carcinoma Patients at Wahidin Sudirohusodo General Hospital Makassar Freddy George Kuhuwael; Muhammad Fadjar Perkasa; Upik Anderiani Miskad; Abdul Qadar Punagi; Fatmawati Arsyad Said
The Indonesian Biomedical Journal Vol 8, No 2 (2016)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v8i2.213

BACKGROUND: Nasopharyngeal carcinoma (NPC) is malignant tumor growing in nasopharynx with a predilection in fossa Rossenmuller and nasopharyngeal roof. This research aimed to prove whether the means of argyrophilic nucleolar organizer region (mAgNOR) can predict the success of treatment in nasopharyngeal carcinoma patients.METHODS: We used diagnostic test method with longitudinal design and purposive sampling technique. Endoscopic biopsy examination was performed on 15 nasopharyngeal carcinoma patients before and after therapy, 13 patients underwent chemotherapy and other two underwent chemoradiotherapy. Tumor tissues were stained and AgNOR was calculated.RESULTS: Based on the tumor stage, sample characteristic showed 3 patients (20%) were in stage II, 3 patients (20%) in stage III, and 9 patients (60%) in stage IV, with pre- and post-therapy mAgNOR were 1.610±0.988 and 1.000±0.000, respectively in stage II, 1.100±0.092 and 1.000±0.000, respectively in stage III, 1.226±0.265 and 1.107±0.164, respectively in stage IV patients. Based on histopathology type, 4 patients (26.7%) had non keratinizing squamous cell carcinoma with pre- and post-therapy mAgNOR were 1.117±0.134 and 1.060±0.120, respectively, while 11 patients (73.3%) had undifferentiated squamous cell carcinoma with pre- and post-therapy mAgNOR were 1.335±0.528 and 1.065±0.146, respectively. Overall the pre-therapy were significantly higher than post-therapy mAgNOR. In subgroups there are significant differences in stage IV and type 3.CONCLUSION: The values of AgNOR were decreased in all NPC stages and significantly decreased in undifferentiated squamous cell carcinoma. AgNOR can be used to predict the successfulness of therapy in NPC.KEYWORDS: nasopharyngeal carcinoma, therapy, proliferation, mAgNOR

IL-1β Expression of Patients with Chronic Rhinosinusitis is negatively correlated with Lund-Mackay score Lidya Turupadang; Muhammad Fadjar Perkasa; Abdul Qadar Punagi; Azmi Mi'rah Zakiah; Burhanuddin Bahar
Nusantara Medical Science Journal Volume 6 Issue 2, July - December 2021
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v6i2.18765

Introduction: IL-1β is one of the proinflammatory cytokines which is commonly found in various diseases, including Chronic Rhinosinusitis (CRS). It has been widely targeted as a therapeutic approach for inflammatory diseases. However, study of IL-1β expression and its correlation with CT-Scan grading scores in CRS is still scarce. Objective: To investigate IL-1β expression based on immunohistochemical examination and analyse its correlation with Lund-Mackay score in CRS with and without polyps. Method: This analytic observational study was done on 50 patients: 25 subjects in the CRS with Nasal Polyps (CRSwNP) group and 25 subjects in the CRS without Nasal Polyps (CRSsNP) group. The uncinate process was taken for immunohistochemical examination of IL-1β. Lund-Mackay score was calculated based on CT-Scan of the paranasal sinus. Result: IL-1β expression in CRSsNP (mean=36.38) was significantly higher than that in the CRSwNP (mean=14.62) with p<0.001. Lund-Mackay score in CRSwNP was higher (mean=35.22) compared to CRSnNP group (mean=15.78) with p<0.001. There was a moderate negative correlation (-0.403) between IL-1β expression and Lund-Mackay score (p<0.05). Conclusion: There was a moderate negative correlation between IL-1β expression and Lund-Mackay score. The IL-1β and the Lund-Mackay score in CRSwNP were lower and higher, respectively, than in CRSsNP

The Examination of Olfactory Function and Mucocilliary Transport in Gas Station Officers in Makassar, Indonesia Rahmat Hidayat; Eka Savitri; Muhammad Fadjar Perkasa; Abdul Punagi
Nusantara Medical Science Journal Volume 7 Issue 1, January - June 2022
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v7i1.19233

Introduction: Chronic exposure to fuel oil can cause chemical burns to the olfactory epithelium, which can cause anosmia. This study aimed to compare mucociliary transport time and olfactory function between operator and non-operator officers at gas stations. Methods: This cross-sectional study was conducted from September to November 2020 and involved 40 subjects divided into two equal groups each consisting of 20 gas station operators and non-operators, respectively. The examination of mucociliary transport time was carried out by saccharin test, while the olfactory function was examined by assessing e olfactory threshold, discrimination, and identification (TDI) score using the Sniffin sticks test. Results: There was a significant difference in the mean mucociliary transport time and olfactory function between gas station operators and non-operators (P<0.001). In addition, there was also a significant correlation between the mucociliary transit time and olfactory function (p<0.05), with a strong negative correlation coefficient (r=-0.620). Therefore, the longer the mucociliary transit time, the gas station attendant's olfactory function will decrease. Conclusion: mucociliary transport time and olfactory function in non-operator public gas station officers were better than operators, probably because inhalation of chemical pollutants induces the release of proinflammatory cytokines, chronic inflammation of the nasal mucosa results in impaired olfactory cells and mucin glands.

Hubungan tipe deviasi septum nasi klasifikasi Mladina dengan kejadian rinosinusitis dan fungsi tuba Eustachius Tanty Tanagi Toluhula; Abdul Qadar Punagi; Muhammad Fadjar Perkasa
Oto Rhino Laryngologica Indonesiana Vol 43, No 2 (2013): Volume 43, No. 2 July - December 2013
Publisher : PERHATI-KL

Latar belakang: Deviasi septum nasi yang mengubah aliran udara dalam rongga hidung dapat mempengaruhi fungsi drainase dan ventilasi sinus paranasal dan tuba Eustachius. Tujuan: Untuk mengetahui apakah terdapat hubungan antara tipe deviasi septum nasi menurut klasifikasi Mladina dengan kejadian rinosinusitis dan fungsi tuba Eustachius. Metode: Penelitian dengan desain cross sectional ini melibatkan 70 penderita deviasi septum nasi. Dilakukan pemeriksaan nasoendoskopik untuk menentukan tipe deviasi septum berdasarkan klasifikasi Mladina,pemeriksaan CT Scan sinus paranasal potongan koronal untuk menentukan adanya rinosinusitis dan timpanometri untuk menentukan fungsi tuba Eustachius. Data dianalisis menggunakan uji chi square likelihood ratio. Hasil:Hasil penelitian menunjukkan bahwa tipe deviasi septum nasi yang paling banyak ditemukan adalah tipe 5 yaitu dengan orientasi horisontal (38,6%). Kejadian rinosinusitis pada penderita deviasi septum nasi sebanyak 54 kasus (77,1%), tipe timpanogram pada penderita deviasi septum nasi yang terbanyak adalah tipe A (82,9%), sedangkan tipe B (1,4%), tipe C (4,3%) dan mayoritas mengalami gangguan fungsi tuba Eustachius (62,9%). Hasil uji statistik menunjukkan nilai p>0,05 yang berarti tidak didapatkan hubungan yang bermakna antara tipe deviasi septum nasi menurut klasifikasi Mladina dengan kejadian rinosinusitis dan fungsi tuba Eustachius. Kesimpulan: Walau tidakterdapat hubungan yang bermakna antara tipe deviasi septum nasi dengan klasifikasi Mladina namun dari segi jumlah lebih banyak ditemukan rinosinusitis dan gangguan fungsi tuba Eustachius pada penderita deviasi septum nasi. Kata kunci: Deviasi septum, klasifikasi Mladina, rinosinusitis, fungsi tuba Eustachius.

Analisis pedigree gangguan pendengaran dan ketulian pada penduduk dusun Sepang, Polewali Mandar, Sulawesi Barat Muhammad Fadjar Perkasa; Abdul Qadar Punagi; Khaeruddin K
Oto Rhino Laryngologica Indonesiana Vol 42, No 1 (2012): Volume 42, No. 1 January - June 2012
Publisher : PERHATI-KL

Background. Pedigree Analysis of hearing loss and deafness in the population of Sepang hamlet, Tenggelang village, Luyo district, Polewali Mandar regency, West Sulawesi. Purpose: To determine the inheritance pattern of hearing loss and deafness in the population of Sepang Hamlet. Methods: Explorative study was conducted among 167 people using pure tone audiometry Interacoustics AD229 type, impedance audiometry Madsen Electronics Zodiac type 901 and Otoread Interacoustics TEOAE. Pedigree of the subjects were made and analyzed. Results: The result of Chi-square goodness of fit showed that the test of conformity with the notion of inheritance pattern of hearing loss and deafness were autosomal dominant, obtain the results of χ²= 6.721>χ² = 3.84 and p value =0,01<0,05, with df = 1, while assuming conformance testing inheritance pattern of hearing loss and deafness were autosomal recessive, obtain the results of χ ² =0,628 < χ²tabeltabel=3.84 and p value= 0.428>0.05 with df = 1. Conclusion: The inheritancepattern of hearing loss and deafness in familial marriage in the population of Sepang hamlet, Tenggelang village, Luyo district, Polewali Mandar regency, West Sulawesi was found to be autosomal recessive transmission. Keywords: pedigree analysis, familal marriage, hearing loss, deafness, Polewali Mandar, West Sulawesi. Abstrak : Latar Belakang: Gangguan pendengaran dan ketulian ditemukan pada penduduk Dusun Sepang, Desa Tenggelang, Kecamatan Luyo, Kabupaten Polewali Mandar Sulawesi Barat yang mempunyai adat perkawinan keluarga. Tujuan: Analisis pedigree ini bertujuan menentukan pola pewarisan gangguan pendengaran dan ketulian pada penduduk dusun tersebut. Metode: Jenis penelitian ini adalah studi eksploratif dengan jumlah subjek sebanyak 167 orang. Pemeriksaan yang dilakukan adalah audiometri nada murni menggunakan audiometer merk Interacoustics tipe AD229, Audiometer impedans merk Madsen Electronics tipe Zodiac 901 dan TEOAE merk Interacoustics tipe Otoread. Subjek dibuatkan pedigree dan dianalisis. Hasil: Uji statistik chi-square test goodness of fit menunjukkan bahwa uji kesesuaian dengan anggapan pola pewarisan gangguan pendengaran dan ketulian secara autosomal dominan didapatkan nilai χ² hasil=6,721 > χ² = 3,84 dan nilai p= 0,01<0,05 dengan df = 1, sedangkan uji kesesuaian dengan anggapan pola pewarisan gangguan pendengaran dan ketulian secara autosomal resesif didapatkan nilai χ² hasil=0,628 <χ²tabeltabel =3,84 dan nilai p=0,428>0,05 dengan df =1. Kesimpulan: Pola pewarisan gangguan pendengaran dan ketulian pada perkawinan keluarga pada penduduk dusun Sepang, Desa Tenggelang, Kecamatan Luyo, Kabupaten polewali Mandar Sulawesi Barat terjadi melalui transmisi autosomal resesif. Kata Kunci : analisis pedigree, perkawinan keluarga, gangguan pendengaran, ketulian, Polewali Mandar, Sulawesi Barat

Penanganan meningosil dan atresia koana bilateral Muhammad Fadjar Perkasa
Oto Rhino Laryngologica Indonesiana Vol 43, No 1 (2013): Volume 43, No. 1 January - June 2013
Publisher : PERHATI-KL

Latar belakang: Atresia koana adalah tertutupnya satu atau kedua posterior kavum nasi oleh membranabnormal atau tulang. Hal ini dapat terjadi bersamaan dengan kelainan kongenital lainnya. Atresia koanabilateral menyebabkan keadaan darurat pada saat kelahiran. Angka kejadian atresia koana adalah 1 kasus per5000 - 8000 kelahiran. Kejadian pada perempuan dua kali lebih banyak daripada laki-laki. Tujuan: Membahassatu kasus bayi dengan atresia koana bilateral yang didiagnosis di ruang operasi, yang tidak terdeteksisebelumnya karena adanya meningosil. Kasus: Bayi perempuan 16 hari dengan meningosil dan atresia koanabilateral. Penatalaksanaan: Pasien menjalani koanoplasti transnasal dan pemasangan stent. Pasien sembuhdengan baik. Kesimpulan: Atresia koana dapat terjadi bersama dengan kelainan kongenital lainnya, sehinggamemerlukan pemeriksaan yang teliti karena atresia koana bilateral menyebabkan keadaan darurat danmemerlukan penanganan segera.Kata kunci : atresia koana, koanoplasti, stent.ABSTRACTBackground: Choanal atresia is a condition where one or both posterior nasal cavity is blocked byabnormal bony or soft tissue. This condition can occur concomitant with other congenital anomalies. Bilateralchoanal atresia causes emergency situation at birth. The incidence of choanal atresia is one case per 5000-8000births and are twice as much in females. Purpose: To discuss a case of bilateral choanal atresia which wasdiagnosed in the operating theatre, undetected previously because of the meningocele. Case: A baby girl 16 daysold with meningocele and bilateral choanal atresia. Management: The patient underwent transnasalchoanoplasty and stenting. The result was satisfactory. Conclusion: Choanal atresia can occure with othercongenital abnormalities, so careful examination is mandatory as bilateral choanal atresia needs promptmanagement.Keywords : choanal atresia, choanoplasty, stent

KORELASI HIPERTROFI KONKA INFERIOR TERHADAP DERAJAT DEVIASI SEPTUM NASI MENGGUNAKAN MODALITAS CT SCAN PADA PASIEN DEVIASI SEPTUM NASI Suryani Said; Junus Baan; Mirna Muis; Muhammad Fadjar Perkasa; Andi Alfian Zainuddin
E-Jurnal Medika Udayana Vol 12 No 1 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar

ABSTRAK Latar Belakang: Hubungan antara hipertrofi konka inferior dengan sudut deviasi septum nasi merupakan fenomena yang telah diketahui . Deviasi septum nasi menggambarkan septum nasi yang tidak lurus dan cacat. Masih sangat terbatasnya studi yang melihat adanya keterkaitan antara hipertrofi konka inferior dan derajat deviasi septum nasi pada pasien deviasi septum nasi. Tujuan: Menentukan hubungan antara hipertrofi konka inferior terhadap sudut deviasi septum nasi menggunakan modalitas CT scan. Metode: Penelitian analitik observasional dengan metode cross sectional menggunakan data sekunder dengan menilai letak deviasi septum, derajat deviasi septum nasi, hipertrofi konka inferior berdasarkan offset lateral, lebar konka, lebar tulang dan lebar mukosa medial konka inferior menggunakan modalitas CT untuk melihat korelasi hipetrofi konka inferior terhadap derajat deviasi septum dan uji t-independet (nilai P < 0.05). Hasil: Didapatkan 45 sampe berdasarkan kriteria inklusi. Sampel termuda yaitu 18 tahun dan usia tertua adalah 83 tahun dengan jumlah perempuan 18 orang (40%) dan jumlah laki-laki 27 orang (60%). Hasil penelitian menunjukkan tidak ada hubungan antara letak deviasi terhadap derajat deviasi septum nasi dengan nilai p 0.138 (p > 0,05) serta tidak ada hubungan yang signifikan antara hipertrofi konka inferior, baik pada pengukuran offset lateral, lebar konka inferior, lebar tulang konka inferior dan lebar mukosa medial pada anterior dan posterior terhadap sudut deviasi septum nasi (nilai p > 0,05). Simpulan: Tidak terdapat hubungan yang signifikan antara letak deviasi terhadap derajat deviasi septum nasi serta tidak terdapat hubungan yang signifikan antara hipertrofi konka inferior, baik pada pengukuran offset lateral, lebar konka inferior, lebar tulang konka inferior dan lebar mukosa medial pada anterior dan posterior terhadap sudut deviasi septum nasi. Kata Kunci : Hipertrofi Konka Inferior, Deviasi Septum Nasi, CT Scan

Co-Authors A.A. Ketut Agung Cahyawan W Abdul Punagi Abdul Qadar Punagi Andi Alfian Zainuddin Andi Alfian Zainuddin Azmi Mi'rah Zakiah Burhanuddin Bahar Dewi Kurniawati Eka Savitri Fatmawati Arsyad Said Freddy George Kuhuwael Idris, Nurlaily Junus Baan Khaeruddin K Latief, Nikmatia Lidya Turupadang Mirna Muis Muhammad Ilyas Muhammad Ilyas Muhammad Ridha Maulana Muis, Mirna Nurlaily Idris Rahmat Hidayat Suryani Said Tanty Tanagi Toluhula UPIK ANDERIANI MISKAD, UPIK ANDERIANI

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